Can 3D breast imaging spot more dangerous cancers than standard mammograms?
NCT ID NCT04461808
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether tomosynthesis (a 3D X-ray technique) combined with synthetic 2D images can reduce the number of advanced and interval breast cancers compared to standard digital mammography. Over 10,000 women scheduled for routine screening will be randomly assigned to one of the two methods. The goal is to see if the newer technology catches more aggressive tumors early, when they are easier to treat.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tomosynthesis plus synthetic 2D mammography
- What this could lead to
- If tomosynthesis proves better at catching aggressive cancers early, it could become a new standard for breast cancer screening, potentially reducing deaths.
- What could go wrong
- This is a single-round screening comparison, so long-term benefits are not yet known. Tomosynthesis may also increase false alarms or overdiagnosis.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azienda Ospedaliera Universitaria Integrata
Verona, Italy
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Azienda Ulss 9 Scaligera
Verona, Italy
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Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia
Reggio Emilia, Italy, 42122, Italy
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IRCCS Policlinico San Donato
Milan, Italy
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