New drug cocktails aim to stall metastatic breast cancer

NCT ID NCT05563220

Ongoing Disease control Sponsor: Stemline Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called elacestrant combined with other medicines in people with a common type of advanced breast cancer (ER+/HER2-). The goal is to find safe doses and see if these combinations can slow down cancer growth. About 435 adults with metastatic breast cancer will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER METASTATIC BREAST CANCER

Contacts and locations

Show contact details

Locations

ACCG - Hospital Araujo Jorge

Goiânia, 74605-070, Brazil
ASST degli Spedali Civili di Brescia

Brescia, 25123, Italy
Abdurrahman Yurtaslan Oncology Hospital

Ankara, 0*6200, Turkey (Türkiye)
Advent Health (Florida Hospital) - Altamonte Springs

Altamonte Springs, Florida, 32701, United States
Asan Medical Center

Seoul, 05505, South Korea
Astera Cancer Care

East Brunswick, New Jersey, 08816, United States
Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Cancer Care Northwest

Spokane Valley, Washington, 99216, United States
Cedars Sinai

Los Angeles, California, 90048, United States
Cemaic - Centro De Especialidades Medicas Ambulatorias E Investigacion Clinica

Córdoba, X5008HHW, Argentina
Centre Hospitalier De L'Ardenne

Libramont, 06800, Luxembourg
Centre Hospitalier Lyon SUD- HCL

Lyon, 69495, France
Centre Hospitalier Universitaire (Chu) De Toulouse - Institut Universitaire Du Cancer De Toulouse-Oncopole (Iuct-Oncopole) (Institut Claudius Regaud)

Toulouse, 31059 Cedex 09, France
Centre de Cancérologie du Grand Montpellier

Montpellier, 34070, France
Centre de Cancérologie du Grand Montpellier

Rouen, 76038 Cedex 1, France
Centro Gaucho Integrado de Oncologia; Hematologia; Ensino e Pesquisa - Hospital Mae de Deus/AESC

Porto Alegre, 90850-170, Brazil
Centro Medico Austral

Buenos Aires, C1017AAS, Argentina
Centro Oncologico Riojano Integral (Cori)

La Rioja, 01122, Argentina
City of Hope National Medical Center

Duarte, California, 91010, United States
Clinica Neoplasias Litoral

Itajaí, 88301-220, Brazil
Complejo Hospitalario Universitario A Coruna

A Coruña, 15006, Spain
Cooperman Barnabas Medical Center

New Brunswick, New Jersey, 08901, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Davidoff Rabin Medical Center

Petah Tikva, 49100, Israel
Dothan Hematology and Oncology

Dothan, Alabama, 36303, United States
Fundacion Instituto Valeciano De Oncologia

Valencia, 46009, Spain
Gangnam Severance Hospital

Seoul, 06273, South Korea
George Washington Cancer Center

Washington D.C., District of Columbia, 20037, United States
Grand Hôpital de Charleroi - Site Notre Dame

Charleroi, 06000, Belgium
Highlands Oncology Group

Springdale, Arkansas, 72762, United States
Hospital Arnau De Vilanova

Valencia, 46015, Spain
Hospital Clinic Barcelona

Barcelona, 08036, Spain
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Sao Lucas da PUCRS

Porto Alegre, 90610-000, Brazil
Hospital Sirio-Libanes (HSL) - Centro De Oncologia - Sao Paulo

São Paulo, 01308-050, Brazil
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29010, Spain
IOB Madrd Institute of Oncology Hospital Beata Maria Ana de Jesus

Madrid, 28007, Spain
Institut Gustave-Roussy-Umr 981

Villejuif, 94805, France
Institut Jules Bordet

Anderlecht, 01070, Belgium
Istituto Europeo di Oncologia (IEO)

Milan, 20141, Italy
Istituto Nazionale Tumori "Fondazione PASCALE"

Naples, 80131, Italy
Johns Hopkins School of Medicine

Baltimore, Maryland, 21287, United States
MD Alliance for Multispecialty Research, LLC

Merriam, Kansas, 66204, United States
MD Anderson Cancer Center Texas

Houston, Texas, 77030, United States
Macquarie University

Sydney, 2113, Australia
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic - Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
NEXT Madrid

Pozuelo de Alarcón, 28223, Spain
NYU Langone Health

New York, New York, 10016, United States
North Middlesex University Hospital

London, N18 1QX, United Kingdom
Northwest Medical Specialties (Nwms) - Puyallup - Medical Oncology (Rainier Hematology-Oncology)/Exigent Research Network; LLC

Tacoma, Washington, 98405, United States
Northwestern Feinberg Scholl of Medicine Prentice Women's Hospital

Chicago, Illinois, 60611, United States
OPN Healthcare (Los Alamitos Location)

Los Alamitos, California, 90720, United States
Ospedale Infermi di Rimini - Azienda Unita Sanitaria Locale Della Romagna

Rimini, 47923, Italy
Rambam Heath

Haifa, 352408, Israel
Rocky Mountain Cancer Centers

Lone Tree, Colorado, 80124, United States
Samson Assuta Ashdod University Hospital - The Institute of Oncology

Ashdod, 7747629, Israel
Sarah Cannon Research Institute / Tennessee Oncology

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute UK; Ltd

London, W1G 6AD, United Kingdom
Seoul National University Bundang Hospital

Seongnam-si, 13620, South Korea
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Sheba Medical Center; Center Israel

Ramat Gan, 5265601, Israel
Summit Medical Group

Florham Park, New Jersey, 07932, United States
TOI Clinical Research

Whittier, California, 90603, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
The Clatterbridge Cancer Centre NHS Foundation Trust

Liverpool, L7 8YA, United Kingdom
UCLA UCLA Hem/Onc - Clinical Research Unit

Los Angeles, California, 90095, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94158, United States
UT Health San Antonio

San Antonio, Texas, 78229, United States
Universitaire Ziekenhuizen (Uz) Leuven - Campus Gasthuisberg - Multidisciplinair Borstcentrum (Multidisciplinary Breast Center) (Mbc)

Leuven, 03000, Belgium
University College London Hospitals NHS Foundation Trust; The London Clinic - Main Hospital

London, W1T 7HA, United Kingdom
University of WI - Carbone Cancer Center (Phase II only)

Madison, Wisconsin, 53792, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates

Norfolk, Virginia, 23502, United States
W&IH of RI Breast Health Center of Women and Infants Hospital of Rhode Island

Providence, Rhode Island, 02905, United States
Washington University School of Medicine in St. Louis

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.