New Four-Pronged antibody takes on advanced breast cancer
NCT ID NCT05160545
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a new drug called GNC-035, a tetra-specific antibody designed to attack breast cancer cells in multiple ways. It involves 36 adults with locally advanced or metastatic breast cancer whose disease has worsened after standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it shows any signs of shrinking tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GNC-035 (a tetra-specific antibody given by IV infusion)
What this could lead to
If this works, it could point toward a new treatment option for advanced breast cancer that has stopped responding to standard therapies.
What could go wrong
This is a very early Phase 1 trial with only 36 participants, so it is primarily testing safety and dosing. The drug may not shrink tumors or may cause significant side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dongguan People's Hospital
Dongguan, Guangdong, China
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510120, China
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The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China
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The Third Hospital of Changsha
Changsha, Hunan, China
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West China Hospital，Sichuan University
Chengdu, Sichuan, China
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ZhuJiang Hospital of Southern Medical University
Guangzhou, Guangdong, China