New drug targets rare gene fusions in multiple cancers

NCT ID NCT02568267

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests the drug entrectinib in over 500 people with advanced solid tumors that have specific gene changes (NTRK, ROS1, or ALK fusions). The goal is to see if the drug can shrink tumors and control the disease. Participants have various cancer types, including lung, breast, and brain cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: entrectinib (a targeted cancer drug)
What this could lead to: If successful, this could provide a new treatment option for people with certain rare gene changes in their tumors, potentially shrinking or controlling their cancer.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The drug may not work for all tumor types, and side effects are possible. It is not a cure.

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Conditions

The condition(s) this trial relates to.

anaplastic large cell lymphoma brain cancer breast cancer breast neoplasm cholangiocarcinoma colorectal cancer colorectal neoplasm head and neck neoplasm Head and Neck Neoplasms malignant pancreatic neoplasm melanoma neuroendocrine neoplasm non-small cell lung carcinoma ovarian cancer pancreatic neoplasm renal cell carcinoma salivary gland cancer sarcoma Thyroid Cancer, Papillary thyroid gland papillary carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT SOLID TUMOR BREAST CANCER CHOLANGIOCARCINOMA COLORECTAL CANCER HEAD AND NECK NEOPLASMS LYMPHOMA, LARGE-CELL, ANAPLASTIC MELANOMA NEUROENDOCRINE TUMORS NON-SMALL CELL LUNG CANCER OVARIAN CANCER PANCREATIC CANCER PAPILLARY THYROID CANCER PRIMARY BRAIN TUMORS RENAL CELL CARCINOMA SALIVARY GLAND CANCERS SARCOMAS

Contacts and locations

Locations

Addenbrookes Hospital

Cambridge, CB2 0QQ, United Kingdom
Advocate Medical Group - Park Ridge, Luther Lane - Oncology

Park Ridge, Illinois, 60068, United States
Aichi Cancer Center Hospital

Aichi, 464-8681, Japan
Asan Medical Center.

Seoul, 05505, South Korea
Atrium Health Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Austin Health

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia

Perugia, Umbria, 6132, Italy
Azienda Ospedaliero Universitaria Pisana

Pisa, Tuscany, 56126, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)

Milan, Lombardy, 20162, Italy
Baylor Scott & White Health

Temple, Texas, 76508, United States
Beijing Cancer Hospital

Beijing, 100142, China
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Cancer Center of Guangzhou Medical University

Guangzhou, 528400, China
Cancer Treatment Centers of America

Tulsa, Oklahoma, 74133, United States
Centre Leon Berard

Lyon, 69373, France
Centro Nacional de Investigaciones Oncológicas(CNIO)

Fuenlabrada, Madrid, 28942, Spain
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Klinika Nowotworow Ukladu Chlonnego

Warsaw, 02-781, Poland
Centrum Onkologii-Instytut im.M.Sklodowskiej Curie

Gliwice, 44-101, Poland
City of Hope Cancer Center

Duarte, California, 91010, United States
City of Hope Duarte - Comprehensive Cancer Center, Investigational Drug Services

Duarte, California, 91010, United States
Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley

Las Vegas, Nevada, 89169, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dignity Health St Joseph's Hospital and Medical Center

Phoenix, Arizona, 85013, United States
Duke Cancer Institute

Durham, North Carolina, 27710, United States
Evang. Lungenklinik Berlin Klinik für Pneumologie

Berlin, 13125, Germany
Flinders Medical Centre

Bedford Park, South Australia, 5042, Australia
Florida Cancer Specialists - Sarasota

Sarasota, Florida, 34232, United States
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Lombardy, 20133, Italy
Fudan University Shanghai Cancer Center

Shanghai, 200120, China
Georgetown University Medical Center Lombardi Cancer Center

Washington D.C., District of Columbia, 20007, United States
H. Lee Moffitt Cancer Center and Research Inst.

Tampa, Florida, 33612-9497, United States
Harbin Medical University Cancer Hospital

Harbin, 150081, China
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hospital Clinico Universitario Virgen de la Victoria

Málaga, 29010, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Clínico San Carlos

Madrid, 28040, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hyogo Cancer Center, Dept of Respiratory Medicine

Hyōgo, 673-8558, Japan
Hôpital Nord - AP-HM Marseille#

Marseille, 13915, France
Hôpital de la Timone

Marseille, 13385, France
IOV - Istituto Oncologico Veneto - IRCCS

Padova, Veneto, 35128, Italy
Institut Bergonie

Bordeaux, 33076, France
Institut Claudius Regaud

Toulouse, 31059, France
Institut Curie

Paris, 75005, France
Institut De Cancerologie De L'ouest - Rene Gauducheau - Biology

Saint-Herblain, 44805, France
Institut Gustave Roussy

Villejuif, 94805, France
Institut de Cancerologie de l Ouest

Angers, 49055, France
Institut de Recherche en Cancérologie de Montpellier

Montpellier, 34090, France
Karmanos Cancer Center

Detroit, Michigan, 48201, United States
Kindai University Hospital

Osaka, 589-8511, Japan
Leids Universitair Medisch Centrum

Leiden, 2333 ZA, Netherlands
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Liverpool Hospital

Liverpool, New South Wales, 2170, Australia
Mary Crowley Medical Research Center

Dallas, Texas, 75230, United States
Massachusetts General Hosp CAR

Boston, Massachusetts, 02114, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Phoenix, Arizona, 85054, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10022, United States
Midwestern Regional Medical Center

Zion, Illinois, 60099, United States
Miyagi Cancer Center

Miyagi, 981-1293, Japan
Moffitt Cancer Center

Tampa, Florida, 33612-9497, United States
NCT Uniklinikum Heidelberg

Heidelberg, 69120, Germany
NHO Kyushu Cancer Center

Fukuoka, 811-1395, Japan
NHO Shikoku Cancer Center

Matsuyama, 791-0280, Japan
NKI The Netherlands Cancer Institute

Amsterdam, 1066 CX, Netherlands
National Cancer Center Hospital

Chūō, 104-0045, Japan
National Cancer Center Hospital

Kashiwa-shi, 277-8577, Japan
National Cancer Centre Singapore

Singapore, 168583, Singapore
National Cheng Kung University Hospital

Tainan, 70457, Taiwan
National Taiwan University Hospital

Taipei, 00100, Taiwan
National University Hospital

Singapore, 119228, Singapore
Newcastle Private Hospital

Newcastle, New South Wales, 2305, Australia
Niigata Cancer Center Hospital

Niigata, 951-8566, Japan
North Shore Hem Onc Associates

East Setauket, New York, 11733, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSU, James Cancer Hospital

Columbus, Ohio, 43210, United States
Ohio State University

Columbus, Ohio, 43210, United States
Oregon Health & Science Univ

Portland, Oregon, 97239, United States
Oregon Health & Science University

Portland, Oregon, 97239-3098, United States
Osaka City General Hospital

Osaka, 534-0021, Japan
Pharmacy

Edegem, 2650, Belgium
Princess Margaret Hospital

Hong Kong, Hong Kong
Queen Elizabeth Hospital

Kowloon, Hong Kong
Regents of the University of Minnesota

Minneapolis, Minnesota, 55455, United States
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute

London, W1G 6AD, United Kingdom
Sarcoma Oncology Center

Santa Monica, California, 90403, United States
Sarcoma Oncology Research Center LLC

Santa Monica, California, 90403, United States
Scripps Clinic

La Jolla, California, 92037, United States
Seconda Università degli Studi di Napoli

Naples, Campania, 80131, Italy
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 120-752, South Korea
Shanghai chest hospital

Shanghai, 200030, China
Shenzhen People's Hospital

Shenzhen, 510852, China
Shizuoka Cancer Center

Shizuoka, 411-8777, Japan
Sichuan Cancer Hospital

Chengdu, Sichuan, 610041, China
Southeastern Regional Medical Center, Inc.

Newnan, Georgia, 30265, United States
Southern California Kaiser Permanente

Los Angeles, California, 90027, United States
Szpital Kliniczny Przemienienia Panskiego Uni. Medycznego im. Karola Marcinkowskiego

Późna, 60-569, Poland
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The Chinese University of Hong Kong

Shatin, 123456, Hong Kong
The Christie

Manchester, M20 4BX, United Kingdom
The University of Hong Kong

Hong Kong, Hong Kong
UCSF Mission Bay

San Francisco, California, 94158, United States
UCSF Mount Zion Medical Ctr

San Francisco, California, 94115, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430023, China
Univ Of California Irvine College Of Medicine

Orange, California, 92868, United States
Universitaetsklinikum Carl Gustav Carus an der TU Dresden

Dresden, 01307, Germany
Universitaetsklinikum Koeln

Cologne, 50937, Germany
Universitaetsmedizin Goettingen

Göttingen, 37075, Germany
University Cancer & Blood Center, LLC

Athens, Georgia, 30607, United States
University of California San Diego Moores Cancer Center

La Jolla, California, 92093, United States
University of Colorado Cancer Center

Aurora, Colorado, 80045, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Southern California Medical Center

Los Angeles, California, 90032, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Utah Hospitals & Clinics

Salt Lake City, Utah, 84112, United States
University of Washington Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Università Campus Bio-Medico di Roma

Rome, Lazio, 128, Italy
Uniwersyteckie Centrum Kliniczne

Gda?sk, 80-214, Poland
Vall d?Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, 08035, Spain
Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates - Hampton

Norfolk, Virginia, 23502, United States
Washington University

St Louis, Missouri, 63128, United States
Weinberg Cancer Institution at Franklin Square

Baltimore, Maryland, 21237, United States
Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Yale University

New Haven, Connecticut, 6519, United States
Zhejiang Cancer Hospital

Hangzhou, 310022, China

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