New drug cocktail aims to tackle Hard-to-Treat cancers

NCT ID NCT06244485

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing whether combining valemetostat tosylate with two different antibody-drug conjugates (T-DXd or Dato-DXd) is safe and effective for people with advanced solid tumors. About 210 adults with at least one measurable tumor will receive the drugs orally and by IV. The study looks for side effects and tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

valemetostat tosylate combined with either T-DXd (Enhertu) or Dato-DXd

What this could lead to

If successful, this could point toward a new combination treatment for advanced solid tumors that are hard to treat.

What could go wrong

This is an early Phase 1b trial, so safety and effectiveness are not yet proven. The combination may cause unexpected side effects or fail to shrink tumors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer gastric adenocarcinoma gastroesophageal junction adenocarcinoma non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aichi Cancer Center Hospital
RECRUITING

Nagoya, 464-8681, Japan
Brcr Medical Center, Inc Dba Boca Raton Clinical Research
RECRUITING

Plantation, Florida, 33322, United States
City of Hope At Orange County Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618, United States
Clinical Research Alliance
RECRUITING

Westbury, New York, 11590, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
H. Lee Moffitt Cancer Center and Research Institute, Inc
WITHDRAWN

Tampa, Florida, 33612, United States
Harbin Medical Univeristy Cancer Hospital
RECRUITING

Heilongjiang, 150081, China
Hunan Cancer Hospital
RECRUITING

Hunan, 410013, China
IRCCS Istituto Scientifico Romagnolo Per
RECRUITING

Cesena, 47014, Italy
Inova Schar Cancer Institute
WITHDRAWN

Fairfax, Virginia, 22031, United States
Jilin Cancer Hospital
RECRUITING

Jilin City, 130000, China
Jinana Center Hosptial
RECRUITING

Shandong, 240013, China
Kanagawa Cancer Center
RECRUITING

Yokohama, 241-8515, Japan
Kindai University Hospital
RECRUITING

Ōsaka-sayama, 589-8511, Japan
Mary Crowley Cancer Research Centers
RECRUITING

Dallas, Texas, 75230, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan-Kettering Cancer Center (Mskcc) - New York
RECRUITING

New York, New York, 10065, United States
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277-8577, Japan
National Hospital Org-Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
Next Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Osaka International Cancer Institute
RECRUITING

Osaka, 540-0008, Japan
Osaka University Hospital
RECRUITING

Suita, 565-0871, Japan
Peking University Third Hospital
RECRUITING

Beijing, 100191, China
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Sharp Memorial Hospital
RECRUITING

San Diego, California, 92123, United States
Shizuoka Cancer Center
RECRUITING

Shizuoka, 411-8777, Japan
Sun Yat-Sen University, Cancer Center
RECRUITING

Guangzhou, 510060, China
SunYat-Sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
The Cancer Institute Hospital of Jfcr
RECRUITING

Kōtoku, 135-8550, Japan
The Cleveland Clinic Foundation
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44195, United States
Unc Hospitals
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Hawaii At Manoa
RECRUITING

Honolulu, Hawaii, 96813, United States
University of Texas M. D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Ut Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Valkyrie Clinical Trials
WITHDRAWN

Los Angeles, California, 90067, United States