New hope for tough breast cancer: drug combo aims to stall tumor growth
NCT ID NCT04851613
First seen Sep 30, 2025 · Last updated May 13, 2026 · Updated 38 times
Summary
This study tests whether adding afuresertib to the standard hormone therapy fulvestrant can help people with a certain type of advanced breast cancer (HR+/HER2-) that has stopped responding to usual treatments. About 256 adults whose cancer has specific genetic changes (PIK3CA/AKT1/PTEN) will receive either the combination or a placebo plus fulvestrant. The main goal is to see if the combination delays cancer progression.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Affiliated Hospital of Hebei University
Baoding, Hebei, 071000, China
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Affiliated Hospital of Nantong University
Nantong, Jiangsu, China
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Anhui Provincial Cancer Hospital
Hefei, Anhui, 230031, China
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Anyang cancer hospital
Anyang, Henan, 455000, China
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Beijing Cancer Hospital
Beijing, Beijing Municipality, 100142, China
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Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100021, China
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Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, 400030, China
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Fujian Cancer Hospital
Fuzhou, Fujian, 350014, China
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Guangxi Zhuang Autonomous Region People's Hospital
Nanning, Guangxi, 530021, China
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Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, 150081, China
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Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
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Hubei Cancer Hospital
Wuhan, Hubei, 430079, China
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Hunan Cancer Hospital
Changsha, Hunan, 410013, China
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Jiangsu Cancer Hospital
Nanjing, Jiangsu, 210009, China
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Jiangsu Provincial People's Hospital
Nanjing, Jiangsu, 210029, China
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Jilin Provincial Cancer Hospital
Changchun, Jilin, 130012, China
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Liaoning Cancer Hospital
Shenyang, Liaoning, 110000, China
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Ningbo Li Huili Hospital
Ningbo, Zhejiang, 315040, China
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Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, 225001, China
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Peking Union Medical College Hospital (PUMCH)
Beijing, Beijing Municipality, 100730, China
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Piedmont Cancer Institute
Atlanta, Georgia, 30318, United States
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Providence St. Johns Health Center
Santa Monica, California, 90404, United States
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Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200020, China
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Shandong Cancer Hospital
Jinan, Shandong, 250117, China
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Shengjing Hospital of China Medical University
Shenyang, Liaoning, 110004, China
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Sichuan Cancer Hospital
Chengdu, Sichuan, 610041, China
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Sichuan Provincial People's Hospital
Chengdu, Sichuan, 610072, China
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Sir-run shaw Hospital Zhejiang University of Medicine
Hangzhou, Zhejiang, 310016, China
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Sun Yat-sen Memorial Hospital，Sun Yat-sen University
Guangzhou, Guangdong, 510000, China
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Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, 510050, China
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Taizhou Hospital
Taizhou, Zhejiang, 317000, China
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Tangshan People's Hospital
Tangshan, Hebei, 063000, China
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The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, 233004, China
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400016, China
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The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, 530021, China
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The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215006, China
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The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, 710061, China
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The First Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310003, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
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The First Hospital of China Medical University
Shenyang, Liaoning, 110001, China
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The First People's Hospital of Foshan
Foshan, Guangdong, 528000, China
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The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, 050011, China
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The first hospital of Jilin University
Changchun, Jilin, 130000, China
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Tianjin Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, 300060, China
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of Vermont
Burlington, Vermont, 05401, United States
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
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Wuhan Central Hospital
Wuhan, Hubei, 430022, China
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
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Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, 200032, China
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Zhongshan People's Hospital
Zhongshan, Guangdong, 528403, China
Conditions
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