One-Time radiation during breast surgery: can imaging pick the right patients?

NCT ID NCT00556907

Terminated Disease control Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether mammography and breast MRI could help identify patients with early-stage breast cancer (DCIS) who could safely receive a single dose of radiation during surgery, instead of weeks of daily radiation afterward. The goal was to avoid repeat surgeries and extra radiation. The trial was stopped early after enrolling 36 people, so the findings are not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intraoperative radiotherapy (radiation given during surgery)
What this could lead to: If successful, this approach could reduce the need for repeat surgeries and additional radiation in some breast cancer patients.
What could go wrong: The trial was terminated early with only 36 participants, so results are limited. It is unclear if the method works better than standard care.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

USC/Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.