Heart shield for breast cancer patients: Beta-Blocker may prevent chemo side effect

NCT ID NCT03879629

First seen Nov 20, 2025 · Last updated May 08, 2026 · Updated 26 times

Summary

This study looks at whether the beta-blocker carvedilol can prevent or treat heart problems in breast cancer patients receiving HER2-targeted therapy. About 184 adults with HER2-positive breast cancer are randomly assigned to start carvedilol either before or after signs of heart strain appear. The goal is to find the best timing and duration of heart protection during cancer treatment.

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Contacts and locations

Locations

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Washington University in St. Louis

    St Louis, Missouri, 63110, United States

Conditions

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