No knife needed? new trial tests if chemo and radiation alone can cure breast cancer
NCT ID NCT06498154
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether women with certain aggressive breast cancers (triple negative or HER2-positive) can safely avoid breast surgery if their tumors disappear completely after a combination of chemotherapy and radiation. The study will enroll 200 women and follow them for 5 years to see if the cancer stays away. If it works, it could spare many patients from surgery and its recovery time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chemotherapy (TCb regimen with or without immunotherapy for triple negative; TCb plus trastuzumab and pertuzumab for HER2+) and radiotherapy (whole-breast irradiation plus boost)
What this could lead to
If successful, this could show that some breast cancer patients can avoid surgery entirely after strong chemo and radiation, reducing treatment burden.
What could go wrong
This is a phase 2 trial with only 200 people, so results are preliminary. There is a risk that cancer may return without surgery, and the combination of chemo and radiation may cause more side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Tianjin medical university cancer institute and hospital
RECRUITINGTianjin, China
Contact Phone: •••-•••-•••• Email: •••••@•••••