A genetic score could sharpen breast cancer risk prediction
NCT ID NCT06922708
First seen Jul 31, 2026 · Last updated Aug 04, 2026 · Updated 2 times
Summary
This study tests whether adding a polygenic risk score (PRS) — a measure based on 313 genetic markers — to the standard CanRisk model can improve breast cancer risk prediction and prevention. About 100 women at increased risk will receive genetic counseling, a blood draw, and the PRS result, then answer questionnaires about their understanding and emotional response. The goal is to see if this integrated approach is practical, acceptable, and helpful in a real-world clinic setting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Polygenic risk score (PRS) testing integrated into the CanRisk model, alongside standard genetic counseling
- What this could lead to
- If successful, this could make breast cancer risk prediction more precise, enabling earlier and more personalized prevention strategies for women at higher risk.
- What could go wrong
- This is a small feasibility study, not a large trial, so it may not prove that PRS improves outcomes. The added psychological impact and the complexity of integrating PRS into routine care are also potential challenges.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BREAST CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Policlinico Universitario Fondazione Agostino Gemelli
RECRUITINGRoma, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a radioactive tracer pinpoint Cancer's first stop?
- Can a personalized exercise program boost recovery in cancer survivors?
- Smartwatch could spot nerve damage before it starts
- Could ionized gas help fight breast cancer after surgery?
- Radiation may let breast cancer patients keep their nipple
- Can a new drug combo revive Immunotherapy's power against resistant tumors?