New hope for advanced breast cancer: experimental drug targets resistant tumors

NCT ID NCT07214662

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This early-stage trial tests a new drug, GDC-0587, alone or with another drug (giredestrant), in people with advanced ER-positive, HER2-negative breast cancer whose cancer worsened after prior CDK4/6 inhibitor therapy. The study aims to find safe doses and check for side effects. About 136 participants will take part.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 70403, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, Taipei City, 10002, Taiwan

  • START - Midwest - EDOS

    RECRUITING

    Grand Rapids, Michigan, 49546-7062, United States

  • START - San Antonio - EDOS

    RECRUITING

    San Antonio, Texas, 78229-3307, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.