New study aims to decode BRCA breast cancer biology for smarter treatment

NCT ID NCT07617025

Recruiting now Knowledge-focused Sponsor: Angela Toss Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study will analyze tumor tissue from 100 people with BRCA1 or BRCA2 mutations and HR-positive, HER2-negative breast cancer. Researchers want to see if different molecular subtypes are linked to how well patients respond to hormone therapy or CDK4/6 inhibitors. No extra tests or procedures are needed beyond standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better predict which BRCA-related breast cancers may respond to specific treatments like CDK4/6 inhibitors.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test new therapies, and findings may not change care immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Azienda Ospedaliero-Universitaria Policlinico di Modena
RECRUITING

Modena, 41124, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori Milano
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli di Roma
RECRUITING

Roma, 00168, Italy
Istituto Oncologico Europeo di Milano
RECRUITING

Milan, 20141, Italy
Istituto Oncologico Veneto IRCCS Padova
RECRUITING

Padova, 35128, Italy
Ospedale San Martino di Genova
RECRUITING

Genova, 16132, Italy

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