New study aims to decode BRCA breast cancer biology for smarter treatment
NCT ID NCT07617025
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This observational study will analyze tumor tissue from 100 people with BRCA1 or BRCA2 mutations and HR-positive, HER2-negative breast cancer. Researchers want to see if different molecular subtypes are linked to how well patients respond to hormone therapy or CDK4/6 inhibitors. No extra tests or procedures are needed beyond standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help doctors better predict which BRCA-related breast cancers may respond to specific treatments like CDK4/6 inhibitors.
What could go wrong
This is an observational study, not a treatment trial. It will not directly test new therapies, and findings may not change care immediately.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azienda Ospedaliero-Universitaria Policlinico di Modena
RECRUITINGModena, 41124, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fondazione IRCCS Istituto Nazionale dei Tumori Milano
RECRUITINGMilan, 20133, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fondazione Policlinico Universitario Agostino Gemelli di Roma
RECRUITINGRoma, 00168, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Istituto Oncologico Europeo di Milano
RECRUITINGMilan, 20141, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Istituto Oncologico Veneto IRCCS Padova
RECRUITINGPadova, 35128, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ospedale San Martino di Genova
RECRUITINGGenova, 16132, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••