Could two years of hormone therapy be enough for some breast cancers?
NCT ID NCT05297617
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This study tests whether postmenopausal women with a very low-risk type of breast cancer (HR+ HER2-) can safely take hormone therapy for only 2-3 years instead of the standard 5 years. The goal is to maintain protection against cancer spread while reducing side effects and improving quality of life. Participants receive one of three aromatase inhibitors daily.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an aromatase inhibitor (letrozole, anastrozole, or exemestane)
- What this could lead to
- If successful, this could show that a shorter course of hormone therapy is safe for women with very low-risk breast cancer, sparing them years of side effects.
- What could go wrong
- This is a single-arm Phase 2 trial without a comparison group, so results may not be definitive. Shorter therapy might still carry a small risk of distant recurrence.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Hospitalier Universitaire de Limoges
RECRUITINGLimoges, 87042, France
Contact Email: •••••@•••••
Contact
Contact
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Institute Gustave Roussy
NOT_YET_RECRUITINGVillejuif, 94805, France
Contact Email: •••••@•••••
Contact
Contact
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