Could 3 weeks of proton therapy be as safe as 5 for breast cancer?
NCT ID NCT05856773
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares a 3-week course of proton radiation to the standard 5-week course for women with breast cancer who need radiation to the breast or chest wall and nearby lymph nodes. The goal is to see if the shorter schedule causes fewer severe skin and tissue side effects while still controlling the cancer. About 276 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Proton radiation therapy (pencil beam scanning)
What this could lead to
If successful, this could offer a shorter, more convenient radiation schedule for breast cancer patients with fewer severe skin and soft tissue side effects.
What could go wrong
This is a Phase 3 trial, but results may not apply to all breast cancer types. Shorter radiation could still cause side effects or be less effective at preventing recurrence.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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California Protons Cancer Therapy Center
RECRUITINGSan Diego, California, 92121, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Emory Proton Therapy Center
RECRUITINGAtlanta, Georgia, 30308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Inova Schar Cancer Institute
RECRUITINGFairfax, Virginia, 22031, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGScottsdale, Arizona, 85259, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Miami Cancer Institute
RECRUITINGMiami, Florida, 33176, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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New York Proton Center
RECRUITINGNew York, New York, 10035, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida Proton Therapy Institute
RECRUITINGJacksonville, Florida, 32206, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••