Could 3 weeks of proton therapy be as safe as 5 for breast cancer?

NCT ID NCT05856773

Recruiting now Disease control Sponsor: Proton Collaborative Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study compares a 3-week course of proton radiation to the standard 5-week course for women with breast cancer who need radiation to the breast or chest wall and nearby lymph nodes. The goal is to see if the shorter schedule causes fewer severe skin and tissue side effects while still controlling the cancer. About 276 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton radiation therapy (pencil beam scanning)
What this could lead to: If successful, this could offer a shorter, more convenient radiation schedule for breast cancer patients with fewer severe skin and soft tissue side effects.
What could go wrong: This is a Phase 3 trial, but results may not apply to all breast cancer types. Shorter radiation could still cause side effects or be less effective at preventing recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

California Protons Cancer Therapy Center
RECRUITING

San Diego, California, 92121, United States
Dwoskin Proton Therapy Center
RECRUITING

Miami, Florida, 33125, United States
Emory Proton Therapy Center
RECRUITING

Atlanta, Georgia, 30308, United States
Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Maryland Proton Treatment Center
RECRUITING

Baltimore, Maryland, 21201, United States
Mayo Clinic
RECRUITING

Scottsdale, Arizona, 85259, United States
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
New York Proton Center
RECRUITING

New York, New York, 10035, United States
University of Florida Proton Therapy Institute
RECRUITING

Jacksonville, Florida, 32206, United States

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