New vaccine-like shot aims to stop breast cancer recurrence in high-risk patients

NCT ID NCT05232916

Recruiting now Disease control Sponsor: Greenwich LifeSciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This phase 3 trial tests an immunotherapy called GLSI-100 in 750 people with HER2-positive breast cancer who are at high risk of their cancer returning after standard treatment. Participants receive a series of injections over a year to help their immune system target and destroy any remaining cancer cells. The goal is to see if this approach can prevent the cancer from coming back.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Show contact details

Locations

Althaia Xarxa Assistencial Universitària de Manresa
RECRUITING

Manresa, Spain
Azienda Ospedaliera Universitaria Federico II Di Napoli
RECRUITING

Naples, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara
RECRUITING

Novara, Italy
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, Italy
Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant'Orsola IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
RECRUITING

Bologna, Italy
Azienda Ospedaliero-Universitaria Policlinico di Modena
NOT_YET_RECRUITING

Modena, Italy
Baylor College of Medicine - Dan L. Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77057, United States
Centre François Baclesse (CLCC)
RECRUITING

Caen, France
Centre Hospitalier Alpes Leman
RECRUITING

Contamine-sur-Arve, France
Centre Hospitalier Privé Saint-Grégoire
RECRUITING

Saint-Grégoire, France
Centre Hospitalier Privé Sainte-Marie Osny
RECRUITING

Osny, France
Centre Hospitalier Universitaire de Saint-Étienne
RECRUITING

Saint-Priest-en-Jarez, France
Centre Hospitalier de Cholet
RECRUITING

Cholet, France
Centre Lutte Contre le Cancer Paul Strauss
RECRUITING

Strasbourg, France
Centre Léon Bérard
RECRUITING

Lyon, France
Centrum Medyczne MrukMed
RECRUITING

Rzeszów, Poland
City of Hope - Cancer Center Atlanta
RECRUITING

Newnan, Georgia, 30265, United States
City of Hope - Cancer Center Chicago
RECRUITING

Zion, Illinois, 60099, United States
City of Hope - Cancer Center Phoenix
RECRUITING

Goodyear, Arizona, 85338, United States
City of Hope - Duarte Cancer Center
RECRUITING

Duarte, California, 91010, United States
City of Hope - Orange County Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618, United States
Clinica Neolife Băneasa București
RECRUITING

Bucharest, Romania
Clinique Pasteur-Lanroze
RECRUITING

Brest, France
Compass Oncology - Northwest Cancer Specialists
RECRUITING

Tigard, Oregon, 97223, United States
Complejo Hospitalario Universitario de Albacete
RECRUITING

Albacete, Spain
Comprehensive Cancer Centers of Nevada
RECRUITING

Henderson, Nevada, 89052, United States
Consorci Corporació Sanitària Parc Taulí
RECRUITING

Sabadell, Spain
Consorcio Hospital General Universitario de Valencia
RECRUITING

Valencia, Spain
Cooper University Health Care
ACTIVE_NOT_RECRUITING

Camden, New Jersey, 08103, United States
Copernicus Podmiot Leczniczy Sp. z o.o. Wojewódzkie Centrum Onkologii
NOT_YET_RECRUITING

Gdansk, Poland
Elisabeth Krankenhaus GmbH
RECRUITING

Kassel, Germany
Evangelisches Diakonie-Krankenhaus gGmbH
RECRUITING

Bremen, Germany
Evangelisches Kliniken Essen-Mitte gGmbH
RECRUITING

Essen, Germany
Filantropia Clinical Hospital
RECRUITING

Bucharest, Romania
Fondazione IRCCS Istituto Nazionale dei Tumori
NOT_YET_RECRUITING

Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
RECRUITING

Rome, Italy
Frauenärzte am Bahnhofsplatz Hildesheim
NOT_YET_RECRUITING

Hildesheim, Germany
Gesundheits und Pflegezentrum Ruesselsheim gGmbH
RECRUITING

Rüsselsheim am Main, Germany
Gynäkologische Praxisklinik Hamburg-Harburg
RECRUITING

Harburg, Germany
Haematologie-Onkologie im Zentrum MVZ GmbH
RECRUITING

Augsburg, Germany
Heidelberg University
RECRUITING

Mannheim, Germany
Helios Klinikum Berlin-Buch GmbH
RECRUITING

Berlin, Germany
Helios Klinikum Gifhorn GmbH
RECRUITING

Gifhorn, Germany
Helios Universitätsklinikum Wuppertal
RECRUITING

Wuppertal, Germany
Hematology Oncology Associates
NOT_YET_RECRUITING

Medford, Oregon, 97504, United States
Hopitaux Prives De Metz
RECRUITING

Vantoux, France
Hospices Civils de Lyon
NOT_YET_RECRUITING

Pierre-Bénite, France
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Spain
Hospital Clínico Universitario Lozano Blesa
RECRUITING

Zaragoza, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

El Palmar, Spain
Hospital Clínico Universitario Virgen de la Victoria
RECRUITING

Málaga, Spain
Hospital Clínico Universitario de Santiago
RECRUITING

Santiago de Compostela, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital Galdakao-Usansolo
RECRUITING

Galdakao, Spain
Hospital General Universitario Dr. Balmis
RECRUITING

Alicante, Spain
Hospital General Universitario Gregorio Marañón
RECRUITING

Madrid, Spain
Hospital General Universitario Morales Meseguer
RECRUITING

Murcia, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, Spain
Hospital San Pedro de Alcántara
RECRUITING

Cáceres, Spain
Hospital Universitari Arnau de Vilanova (Lleida)
RECRUITING

Lleida, Spain
Hospital Universitari Arnau de Vilanova (Valencia)
NOT_YET_RECRUITING

Valencia, Spain
Hospital Universitari General de Catalunya - Grupo Quirónsalud
RECRUITING

Sant Cugat del Vallès, Spain
Hospital Universitari Son Espases
RECRUITING

Palma de Mallorca, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain
Hospital Universitario Clínico San Cecilio
RECRUITING

Granada, Spain
Hospital Universitario Donostia
RECRUITING

San Sebastián, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, Spain
Hospital Universitario Reina Sofía
RECRUITING

Córdoba, Spain
Hospital Universitario San Juan de Alicante
RECRUITING

Sant Joan d'Alacant, Spain
Hospital Universitario Sant Joan de Reus
RECRUITING

Reus, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Spain
Hospital Universitario de Badajoz
RECRUITING

Badajoz, Spain
Hospital Universitario de Canarias
RECRUITING

San Cristóbal de La Laguna, Spain
Hospital Universitario de Fuenlabrada
RECRUITING

Fuenlabrada, Spain
Hospital Universitario de Jaén
RECRUITING

Jaén, Spain
Hospital Universitario de Jerez de la Frontera
RECRUITING

Jerez de la Frontera, Spain
Hospital Universitario de La Princesa
RECRUITING

Madrid, Spain
Hospital Universitario de Toledo
RECRUITING

Toledo, Spain
Hospital del Mar
RECRUITING

Barcelona, Spain
Hämatologisch Onkologisches Forschungsinstitut
NOT_YET_RECRUITING

Mayen, Germany
Hôpital NOVO (Nord-Ouest Val-d'Oise)
RECRUITING

Pontoise, France
Hôpital Privé Drôme Ardèche
RECRUITING

Valence, France
Hôpital Privé du Confluent
RECRUITING

Nantes, France
Institut Curie
RECRUITING

Paris, France
Institut Curie
RECRUITING

Saint-Cloud, France
Institut Gustave Roussy
RECRUITING

Villejuif, France
Institut Jean Godinot (CLCC)
RECRUITING

Reims, France
Institute of Oncology "Prof Dr Ion Chiricuta"
RECRUITING

Cluj-Napoca, Romania
Istituti Clinici Scientifici Maugeri Spa Società Benefit IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
RECRUITING

Pavia, Italy
Istituto Nazionale Tumori Fondazione Pascale IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
RECRUITING

Naples, Italy
Istituto Oncologico Veneto
RECRUITING

Padova, Italy
Johns Hopkins Medicine - Kimmel Cancer Center-Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Klinikum Bayreuth GmbH
NOT_YET_RECRUITING

Bayreuth, Germany
Klinikum Chemnitz gGmbH
NOT_YET_RECRUITING

Chemnitz, Germany
Klinikum Dortmund gGmbH
NOT_YET_RECRUITING

Dortmund, Germany
Klinikum Frankfurt Höchst GmbH
RECRUITING

Frankfurt, Germany
Klinikum Mutterhaus der Borromäerinnen gGmbH
RECRUITING

Trier, Germany
Klinikum Rheine / Mathias-Spital Rheine
NOT_YET_RECRUITING

Rheine, Germany
Klinikum Südstadt Rostock Eigenbetrieb der Hanse und Universitätsstadt Rostock
RECRUITING

Rostock, Germany
Klinikum Worms gGmbH
RECRUITING

Worms, Germany
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)
NOT_YET_RECRUITING

Munich, Germany
Kostara Gyn Oncology Clinic Research UG
RECRUITING

Düsseldorf, Germany
Krankenhaus St. Elisabeth und St. Barbara Halle (Saale) GmbH
RECRUITING

Halle, Germany
MVZ GynKrefeld GmbH
RECRUITING

Krefeld, Germany
MVZ Nordoberpfalz GmbH
NOT_YET_RECRUITING

Weiden, Germany
MVZ Walsrode
NOT_YET_RECRUITING

Walsrode, Germany
Mammazentrum Hamburg MVZ GbR
RECRUITING

Hamburg, Germany
Marienhospital Bottrop gGmbH
RECRUITING

Bottrop, Germany
Marienhospital Witten
RECRUITING

Witten, Germany
Maryland Oncology Hematology
RECRUITING

Annapolis, Maryland, 21401, United States
Massachusetts General Hospital Cancer Center
RECRUITING

Boston, Massachusetts, 02114, United States
Minnesota Oncology
RECRUITING

Maple Grove, Minnesota, 55369, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
München Klinik gGmbH
RECRUITING

Munich, Germany
National Center For Tumor Diseases (NCT) Heidelberg
RECRUITING

Heidelberg, Germany
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68114, United States
Nebraska Medicine - University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
New York Oncology Hematology
RECRUITING

Albany, New York, 12065, United States
New York-Presbyterian - Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Northwestern University - Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Oncology Hematology Care
RECRUITING

Cincinnati, Ohio, 45211, United States
Oncomed SRL - Oncology Center
RECRUITING

Timișoara, Romania
Ospedale Policlinico San Martino IRCCS (Istituto Di Ricerca E Di Cura A Carattere Scientifico)
RECRUITING

Genova, Italy
PIH Health Hospital - Whittier Hospital
RECRUITING

Whittier, California, 90602, United States
Praxis für Interdisziplinäre Onkologie und Haematologie GbR
RECRUITING

Freiburg im Breisgau, Germany
Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center
RECRUITING

Fullerton, California, 92835, United States
Przychodnia Lekarska KOMED Roman Karaszewski
RECRUITING

Konin, Poland
Pôle Santé Léonard De Vinci
RECRUITING

Chambray-lès-Tours, France
RKH Klinken Ludwigsburg-Bietigheim gGmbH
RECRUITING

Ludwigsburg, Germany
Redeemer Health - Holy Redeemer Hospital
RECRUITING

Meadowbrook, Pennsylvania, 19046, United States
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80220, United States
SCRI Oncology Partners
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States
Sainte-Catherine - Institut du Cancer Avignon-Provence (ICAP)
RECRUITING

Avignon, France
Samodzielny Publiczny Zakład Opieki Zdrowotnej (SPOZOZ) Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
RECRUITING

Opole, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej (ZOZ) Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, Poland
Shenandoah Oncology
NOT_YET_RECRUITING

Winchester, Virginia, 22601, United States
Sidney Kimmel Comprehensive Cancer Center - Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Siteman Cancer Center - Washington University Medical Campus
RECRUITING

St Louis, Missouri, 63110, United States
Southern Cancer Center
NOT_YET_RECRUITING

Mobile, Alabama, 36607, United States
St. Vincent's University Hospital
RECRUITING

Dublin, Ireland
Stanford Medicine Cancer Center - Stanford Women's Cancer Center
RECRUITING

Palo Alto, California, 74304, United States
Stony Brook University Cancer Center
RECRUITING

Stony Brook, New York, 11794, United States
Studien GbR Braunschweig
NOT_YET_RECRUITING

Braunschweig, Germany
Studienzentrale für das MVZ Eggenfelden e.K.
RECRUITING

Eggenfelden, Germany
Städtisches Klinikum Dessau
RECRUITING

Dessau, Germany
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie
RECRUITING

Krakow, Poland
Tennessee Cancer Specialists
NOT_YET_RECRUITING

Knoxville, Tennessee, 37909, United States
Texas Oncology - Austin
RECRUITING

Austin, Texas, 78745, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology - Dallas Presbyterian Hospital
RECRUITING

Dallas, Texas, 75231, United States
Texas Oncology - Gulf Coast
RECRUITING

Sugar Land, Texas, 77479, United States
Texas Oncology - San Antonio Medical Center
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology - Tyler
RECRUITING

Tyler, Texas, 75702, United States
The University of Texas Health Sciences Center at San Antonio - Mays Cancer Center
RECRUITING

San Antonio, Texas, 78229, United States
The University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Tucson Medical Center HealthCare
RECRUITING

Tucson, Arizona, 85704, United States
UZ Leuven
RECRUITING

Leuven, Belgium
Unidade Local de Saúde Santa Maria, E.P.E.
RECRUITING

Lisbon, Portugal
Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
NOT_YET_RECRUITING

Dresden, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
RECRUITING

Mainz, Germany
University of California Los Angeles - Hematology / Oncology Parkside
RECRUITING

Santa Monica, California, 90404, United States
University of California San Diego - Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
University of California San Francisco - Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94158, United States
University of Miami - Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33146, United States
University of Southern California - Norris Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90033, United States
University of Utah - Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Universitätsklinikum Münster
NOT_YET_RECRUITING

Münster, Germany
Universitätsklinikum Ulm AöR
RECRUITING

Ulm, Germany
Universitätsmedizin Göttingen
RECRUITING

Göttingen, Germany
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, Poland
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Norfolk, Virginia, 23502, United States
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Słupsku
RECRUITING

Słupsk, Poland
Wojskowy Instytut Medyczny Państwowy Instytut Badawczy
RECRUITING

Warsaw, Poland
Yale Cancer Center - Smilow Cancer Hospital
RECRUITING

New Haven, Connecticut, 06511, United States

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