Cheap chemical could supercharge breast cancer radiation

NCT ID NCT03946202

Recruiting now Disease control Sponsor: Institute of Cancer Research, United Kingdom Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether injecting a very dilute hydrogen peroxide solution directly into breast tumors can make standard radiotherapy more effective. Researchers are enrolling 184 adults with locally advanced or recurrent breast cancer. Participants will receive injections twice a week during their radiotherapy course. Early results from Japan suggest this approach may dramatically improve tumor shrinkage, but the treatment is still experimental and limited to certain patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hydrogen peroxide
What this could lead to: If it works, this cheap and widely available chemical could make radiotherapy much more effective at shrinking breast tumors, potentially improving local control and survival.
What could go wrong: This is a phase 2 trial with only 184 participants, so results are preliminary. The approach has been tested mainly in Japan, and side effects like injection-site discomfort may limit acceptance. It is not a cure and is only for specific breast cancer cases.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, Scotland, G12 0YN, United Kingdom
Cambridge University Hospitals NHS Foundation Trust
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Christian Medical Centre
RECRUITING

Vellore, Tamil Nadu, 632004, India
Regional Cancer Centre (RCC)
RECRUITING

Trivandrum, Kerala, 695011, India
Royal Cornwall Hospitals NHS Trust
RECRUITING

Truro, Cornwall, TR1 3LJ, United Kingdom
Tata Medical Centre
RECRUITING

Kolkata, West Bengal, 700160, India
Tata Memorial Centre
RECRUITING

Mumbai, India
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Royal Marsden NHS Foundation Trust
RECRUITING

Sutton, SM2 5PT, United Kingdom
University Hospitals of North Midlands NHS Trust
RECRUITING

Stoke-on-Trent, ST4 6QG, United Kingdom

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