New radioactive drug targets Hard-to-Treat cancers

NCT ID NCT04939610

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests a drug called 177Lu-FAP-2286, which delivers radiation directly to cancer cells. It is for people with advanced solid tumors (like pancreatic, lung, or breast cancer) that have a specific protein called FAP. The trial has two parts: Phase 1 finds the safest dose, and Phase 2 checks if the drug shrinks tumors, alone or with chemotherapy. About 222 adults will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 177Lu-FAP-2286 (a radioactive drug that targets cancer cells)
What this could lead to: If it works, this could offer a new treatment option for people with advanced solid tumors like pancreatic, lung, or breast cancer.
What could go wrong: This is an early-phase trial, so the drug may not work or could cause serious side effects. It is only for patients whose tumors show a specific protein (FAP).

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR

Contacts and locations

Locations

City of Hope
RECRUITING

Duarte, California, 91010, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109-1023, United States
Hoag Hospital Irvine
RECRUITING

Irvine, California, 92618, United States
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
London Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Novartis Investigating Site
RECRUITING

London, Ontario, N6A 5W9, Canada
Novartis Investigating Site
RECRUITING

Marseille, 13385, France
Novartis Investigating Site
RECRUITING

Milan, 20141, Italy
Novartis Investigating Site
RECRUITING

Reggio Emilia, 41123, Italy
Novartis Investigating Site
RECRUITING

Badalona, 08916, Spain
Novartis Investigating Site
RECRUITING

Madrid, 28040, Spain
Novartis Investigating Site
RECRUITING

Madrid, 28041, Spain
Novartis Investigating Site
RECRUITING

Madrid, 28050, Spain
Novartis Investigative Site
RECRUITING

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site
RECRUITING

Melbourne, Victoria, 3000, Australia
Novartis Investigative Site
RECRUITING

Melbourne, Victoria, 3004, Australia
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Novartis Investigative Site
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
Novartis Investigative Site
RECRUITING

A Coruña, 15006, Spain
Novartis Investigator Site
RECRUITING

Murdoch, Western Australia, 6150, Australia
Novartis Investigator Site
RECRUITING

Montpellier, Cedex 5, 34298, France
Novartis Investigator Site
RECRUITING

Bordeaux, 33000, France
Novartis Investigator Site
RECRUITING

Clermont-Ferrand, 63011, France
Novartis Investigator Site
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Novartis Investigator Site
RECRUITING

Naples, 80131, Italy
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239-3098, United States
Saint Louis University Hospital
RECRUITING

St Louis, Missouri, 63110-2539, United States
UAB Comprehensive Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
UCSF Medical Center
RECRUITING

San Francisco, California, 94158, United States
UNC Hospitals
RECRUITING

Chapel Hill, North Carolina, 27514, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Univ of Utah, Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
University of California Los Angeles (UCLA)
RECRUITING

Los Angeles, California, 90095, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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