BREAKTHROUGH: breast cancer patients may skip chemo thanks to new drug combo

NCT ID NCT07237256

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a drug called ribociclib can safely replace chemotherapy for women with a common type of early breast cancer (HR+ HER2-). About 3,900 women at intermediate risk of recurrence will receive either standard hormone therapy plus ribociclib or hormone therapy plus chemotherapy. The goal is to see if skipping chemotherapy reduces side effects without lowering the chance of staying cancer-free.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AGAPLESION Markus Krankenhaus
NOT_YET_RECRUITING

Frankfurt, 60431, Germany
AORN Sant'Anna e San Sebastiano
NOT_YET_RECRUITING

Caserta, 81100, Italy
Azienda Ospedaliero Universitaria Pisana
NOT_YET_RECRUITING

Pisa, 56100, Italy
Azienda Ospedaliero-Universitaria Federico II
NOT_YET_RECRUITING

Naples, 80131, Italy
CARIO - Centre Armoricain Radiothérapie Imagerie Médicale et Oncologie
ACTIVE_NOT_RECRUITING

Plérin, France
CH Cholet
NOT_YET_RECRUITING

Cholet, 49300, France
CH Henri Mondor
ACTIVE_NOT_RECRUITING

Aurillac, 15000, France
CH Victor Dupouy
NOT_YET_RECRUITING

Argenteuil, 95107, France
CHI Fréjus St-Raphaël
ACTIVE_NOT_RECRUITING

Fréjus, France
CHU Bretonneau
NOT_YET_RECRUITING

Tours, 37000, France
CHU Grenoble
NOT_YET_RECRUITING

La Tronche, France
CHU Orléans
ACTIVE_NOT_RECRUITING

Orléans, France
CHU Poitiers
NOT_YET_RECRUITING

Poitiers, 86180, France
CHU de NÎMES - Institut de Cancérologie du Gard
NOT_YET_RECRUITING

Nîmes, 30029, France
CHU de Saint Étienne
RECRUITING

Saint-Etienne, 42270, France
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Eugène Marquis
ACTIVE_NOT_RECRUITING

Rennes, 35042, France
Centre Francois Baclesse
NOT_YET_RECRUITING

Caen, 14000, France
Centre Henri Becquerel
NOT_YET_RECRUITING

Rouen, France
Centre Hospitalier Annecy Genevois
NOT_YET_RECRUITING

Metz-Tessy, France
Centre Hospitalier Départemental de Vendée
NOT_YET_RECRUITING

La Roche-sur-Yon, 85925, France
Centre Hospitalier Métropole de Savoie
ACTIVE_NOT_RECRUITING

Chambéry, 73000, France
Centre Hospitalier Simone Veil de Beauvais
ACTIVE_NOT_RECRUITING

Beauvais, 60021, France
Centre Hospitalier Universitaire de Besancon
NOT_YET_RECRUITING

Besançon, 25000, France
Centre Hospitalier Universitaire de Limoges
ACTIVE_NOT_RECRUITING

Limoges, 87042, France
Centre Hospitalier William Morey
ACTIVE_NOT_RECRUITING

Chalon-sur-Saône, France
Centre Hospitalier d'Auxerre
NOT_YET_RECRUITING

Auxerre, France
Centre Hospitalier de Carcassonne
NOT_YET_RECRUITING

Carcassonne, 11000, France
Centre Hospitalier de Pau
ACTIVE_NOT_RECRUITING

Pau, 64046, France
Centre Hospitalier de Quimper
NOT_YET_RECRUITING

Quimper, 29000, France
Centre Hospitalier de Valence
NOT_YET_RECRUITING

Valence, 26000, France
Centre Hospitalier de Versailles
NOT_YET_RECRUITING

Le Chesnay, 78150, France
Centre Hospitalier de la Cote Basque
ACTIVE_NOT_RECRUITING

Bayonne, 64100, France
Centre Hospitalier le Mans
NOT_YET_RECRUITING

Le Mans, 72000, France
Centre Jean Perrin
NOT_YET_RECRUITING

Clermont-Ferrand, 63011, France
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centre Paul Stauss
ACTIVE_NOT_RECRUITING

Strasbourg, France
Centre d'Oncologie et de Radiothérapie 37
NOT_YET_RECRUITING

Chambray-lès-Tours, 37170, France
Centre de Cancerologie du Grand Montpellier
RECRUITING

Montpellier, 34070, France
Clinique Mutualiste de l'Estuaire
ACTIVE_NOT_RECRUITING

Saint-Nazaire, 44600, France
Clinique Tivoli
NOT_YET_RECRUITING

Bordeaux, France
Clinique Victor Hugo
NOT_YET_RECRUITING

Le Mans, 72000, France
Clinique de Flandre
NOT_YET_RECRUITING

Coudekerque-Branche, 59210, France
Clinique de l'Europe
NOT_YET_RECRUITING

Amiens, 80090, France
Clinique de la Croix du Sud
NOT_YET_RECRUITING

Quint-Fonsegrives, 31130, France
Complejo Hospitalario Insular Materno-Infantil
RECRUITING

Las Palmas de Gran Canaria, 35016, Spain
Elisabeth Krankenhaus Kassel
NOT_YET_RECRUITING

Kassel, 34117, Germany
Evangelisches Klinikum Gelsenkirchen
NOT_YET_RECRUITING

Gelsenkirchen, 45879, Germany
Frisius MC
NOT_YET_RECRUITING

Leeuwarden, 8934 AD, Netherlands
GZW Hochwaldkrankenhaus
NOT_YET_RECRUITING

Bad Nauheim, 61231, Germany
Groupe Hospitalier De La Region De Mulhouse Et Sud Alsace (GHRMSA)
RECRUITING

Mulhouse, 68100, France
Groupe Hospitalier Rance Emeraude (GHRE)
NOT_YET_RECRUITING

St-Malo, 35400, France
Gustave Roussy
ACTIVE_NOT_RECRUITING

Villejuif, France
Helios Klinikum Berlin Buch
NOT_YET_RECRUITING

Berlin, 13125, Germany
Hopital Diaconesses-Croix Saint Simon
ACTIVE_NOT_RECRUITING

Paris, 75020, France
Hopital Privé du Confluent
NOT_YET_RECRUITING

Nantes, France
Hopital Saint Louis
NOT_YET_RECRUITING

Paris, 75010, France
Hospices Civils de Colmar
ACTIVE_NOT_RECRUITING

Colmar, 68000, France
Hospices Civils de Lyon - Centre principal: Hôpital Lyon Sud
NOT_YET_RECRUITING

Pierre-Bénite, France
Hospital Clínic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Materno-Infantil Málaga
RECRUITING

Málaga, 29011, Spain
Hospital Severo Ochoa
NOT_YET_RECRUITING

Leganés, 28911, Spain
Hospital Son Universitario Son Llatzer
RECRUITING

Palma de Mallorca, 07198, Spain
Hospital Universitari Parc Taulí
RECRUITING

Sabadell, 08208, Spain
Hospital Universitari Sant Joan de Reus
RECRUITING

Reus, 43204, Spain
Hospital Universitario 12 Octubre
NOT_YET_RECRUITING

Madrid, 28041, Spain
Hospital Universitario Arnau de Vilanova de Lleida
RECRUITING

Lleida, 25198, Spain
Hospital Universitario Clínico San Cecilio
RECRUITING

Granada, 18016, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Rey Juan Carlos
NOT_YET_RECRUITING

Móstoles, 28933, Spain
Hospital Universitario Son Espases
RECRUITING

Palma de Mallorca, 07120, Spain
Hospital Universitario Virgen de la Arrixaca
RECRUITING

Murcia, 30120, Spain
Hospital Universitario Virgen del Rocio
NOT_YET_RECRUITING

Seville, 41013, Spain
Hospital Universitario de Badajoz
RECRUITING

Badajoz, 06006, Spain
Hospital Universitario de Basurto
NOT_YET_RECRUITING

Bilbao, 48013, Spain
Hospital Universitario de Fuenlabrada
NOT_YET_RECRUITING

Fuenlabrada, 28942, Spain
Hospital Universitario de Jaén
RECRUITING

Jaén, 23007, Spain
Hospital Universitario de Jerez
RECRUITING

Jerez de la Frontera, 11405, Spain
Hospital Vall d'Hebrón
RECRUITING

Barcelona, 08035, Spain
Hospital de Mataró
RECRUITING

Mataró, 08304, Spain
Hospital del Mar
NOT_YET_RECRUITING

Barcelona, 08003, Spain
Hämato-Onklogische Praxis im Medicum
NOT_YET_RECRUITING

Bremen, 28209, Germany
Hämatologie-Onkologie im Zentrum MVZ GmbH
NOT_YET_RECRUITING

Augsburg, 86150, Germany
Hôpital NOVO - Site PONTOISE
NOT_YET_RECRUITING

Pontoise, 95300, France
Hôpital Privé Jean Mermoz
ACTIVE_NOT_RECRUITING

Lyon, 69008, France
Hôpital Privé de la Loire
ACTIVE_NOT_RECRUITING

Saint-Etienne, 42100, France
Hôpital Tenon APHP
NOT_YET_RECRUITING

Paris, 75020, France
Hôpitaux du Léman
ACTIVE_NOT_RECRUITING

Thonon-les-Bains, 74200, France
ICO Hospitalet
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
IRCCS Centro di Riferimento Oncologico
NOT_YET_RECRUITING

Aviano, 33081, Italy
IRCCS Fondazione Policlinico Universitaria "A. Gemelli"
NOT_YET_RECRUITING

Roma, 00168, Italy
IRCCS Istituto Nazionale dei Tumori Fondazione "G. Pascale"
NOT_YET_RECRUITING

Naples, 80131, Italy
IRCCS Istituto Oncologico Veneto
NOT_YET_RECRUITING

Padova, 32128, Italy
IRCCS Ospedale Policlinico San Martino - Università di Genova
NOT_YET_RECRUITING

Genova, 16132, Italy
InVO - Institut für Versorgungsforschung in der Onkologie
NOT_YET_RECRUITING

Koblenz, 56068, Germany
Institut Bergonie
NOT_YET_RECRUITING

Bordeaux, 33076, France
Institut Claudius Regaud
RECRUITING

Toulouse, 31059, France
Institut Curie
RECRUITING

Saint-Cloud, 92219, France
Institut Curie
RECRUITING

Paris, Île-de-France Region, 75005, France
Institut Jean Godinot
RECRUITING

Reims, 51100, France
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, France
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, Île-de-France Region, 13009, France
Institut de Cancérologie Paris Nord - GCS RISSA
NOT_YET_RECRUITING

Sarcelles, 95200, France
Institut de Cancérologie de Bourgogne
NOT_YET_RECRUITING

Dijon, 21000, France
Institut de Cancérologie de Lorraine
RECRUITING

Vandœuvre-lès-Nancy, France
Institut de Cancérologie de l'Ouest - Site Paul Papin
NOT_YET_RECRUITING

Angers, 49055, France
Institut de Cancérologie de l'Ouest - Site René Gauducheau
NOT_YET_RECRUITING

Saint-Herblain, 44800, France
Klinikum Esslingen GmbH
NOT_YET_RECRUITING

Esslingen am Neckar, 73730, Germany
Klinikum Worms gGmbH
NOT_YET_RECRUITING

Worms, 67550, Germany
Leids Universitair Medisch Centrum (LUMC)
NOT_YET_RECRUITING

Leiden, 2333 ZA, Netherlands
MVZ Medical Center Düsseldorf GmbH
NOT_YET_RECRUITING

Düsseldorf, 40235, Germany
MVZ für Hämatologie und Onkologie Ravensburg GmbH
NOT_YET_RECRUITING

Ravensburg, 88212, Germany
Mammazentrum HH am Krankenhaus Jerusalem
NOT_YET_RECRUITING

Hamburg, 20357, Germany
Medizinische Universität Lausitz - Carl-Thiem
NOT_YET_RECRUITING

Cottbus, 03048, Germany
Nationales Centrum für Tumorerkrankungen
NOT_YET_RECRUITING

Heidelberg, 69120, Germany
Ospedale F. Lotti Pontedera e Volterra, AUSL Toscana Nord Ovest
NOT_YET_RECRUITING

Pontedera, 56125, Italy
Polyclinique Saint Côme
NOT_YET_RECRUITING

Compiègne, 60200, France
Polyclinique de Blois
NOT_YET_RECRUITING

La Chaussée-Saint-Victor, 41260, France
Polyclinique de Limoges - Site Cinique Chénieux
NOT_YET_RECRUITING

Limoges, 87039, France
Praxisklinik Krebsheilkunde für Frauen / Brustzentrum
NOT_YET_RECRUITING

Berlin, 10367, Germany
Rijnstate Ziekenhuis Stichting
NOT_YET_RECRUITING

Arnhem, 6815 AD, Netherlands
Sainte Catherine - Institut du Cancer Avignon Provence
RECRUITING

Avignon, 84918, France
Sana Klinikum Offenbach
NOT_YET_RECRUITING

Offenbach, 63069, Germany
Spaarne Gasthuis Stichting
NOT_YET_RECRUITING

Hoofddorp, 2134 TM, Netherlands
St. Franziskus-Hospital Münster
NOT_YET_RECRUITING

Münster, 48145, Germany
St.-Antonius-Hospital
NOT_YET_RECRUITING

Eschweiler, 52249, Germany
Stichting Viecuri Medisch Centrum voor Noord-Limburg
NOT_YET_RECRUITING

Venlo, 5912 BL, Netherlands
Tergooiziekenhuizen
NOT_YET_RECRUITING

Hilversum, 1212 VG, Netherlands
University Hospital Münster
NOT_YET_RECRUITING

Münster, 48149, Germany
University of Rostock
NOT_YET_RECRUITING

Rostock, 18059, Germany
Universitätsklinikum Aachen AöR
NOT_YET_RECRUITING

Aachen, 52074, Germany
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
NOT_YET_RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Düsseldorf AöR
NOT_YET_RECRUITING

Düsseldorf, 40225, Germany
Universitätsklinikum Leipzig
NOT_YET_RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Tübingen AöR
NOT_YET_RECRUITING

Tübingen, 72076, Germany
Universitätsklinikum Ulm
NOT_YET_RECRUITING

Ulm, 89075, Germany
Universitätsmedizin Mannheim
NOT_YET_RECRUITING

Mannheim, 68167, Germany