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Brain MRI screening for breast cancer: a new way to catch metastases early?

NCT ID NCT06247449

Recruiting now Diagnosis Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is looking at whether a brain MRI can spot cancer that has spread to the brain in people with certain types of breast cancer (triple negative or HER2-positive, stage IIb or III) who have no symptoms. About 100 participants will get a contrast-enhanced brain MRI, give a blood sample, and fill out a questionnaire about how they feel about the scan. The goal is to find out how common hidden brain metastases are and whether patients find the screening acceptable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Contrast-enhanced brain MRI and blood test for circulating tumor DNA
What this could lead to
If successful, this could show that routine MRI screening helps detect brain metastases early in high-risk breast cancer patients, potentially guiding earlier treatment.
What could go wrong
This is a small, early-stage observational study (100 participants) that only measures how often hidden brain metastases occur and patient attitudes—it does not test whether earlier detection improves outcomes or survival.

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Conditions

The condition(s) this trial relates to.

brain cancer breast cancer breast neoplasm HER2 positive breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

  • Sunnybrook Health Science Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

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