New trial aims to tailor breast cancer therapy using genetic tests
NCT ID NCT05837455
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing whether using specific genetic tests (Ki67 and Oncotype DX) can help doctors choose the best treatment before surgery for women with a common type of breast cancer (ER-positive, HER2-negative). The study includes 81 postmenopausal women with stage II or III disease and focuses on improving outcomes for Black patients. The goal is to see if this personalized approach can increase tumor shrinkage and identify women who may not need chemotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ki67 assay and Oncotype DX test (diagnostic devices to guide treatment choice)
What this could lead to
If successful, this approach could help personalize breast cancer treatment, potentially sparing some women from chemotherapy and improving response rates, especially for Black patients.
What could go wrong
This is a small, early-phase trial (81 participants) testing a strategy, not a new drug. The biomarker approach may not improve outcomes as hoped, and results may not apply to all patients.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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