Blood test may predict implant scarring after breast cancer radiation

NCT ID NCT04342546

Recruiting now Diagnosis Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a blood test called NovaGray RILA Breast® to see if it can predict severe capsular contracture (hardening and tightening of scar tissue around a breast implant) after radiotherapy. Researchers will enroll 250 breast cancer patients who have had a mastectomy with immediate implant reconstruction and need chest wall radiation. The test is done before and after radiotherapy, and its accuracy will be compared to actual outcomes over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NovaGray RILA Breast® test (blood test)
What this could lead to: If successful, this test could help doctors identify patients at high risk for severe capsular contracture before radiotherapy, allowing personalized treatment planning.
What could go wrong: This is an early-stage diagnostic study, not a treatment trial. The test may not accurately predict toxicity in all patients, and results may not change outcomes.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER CAPSULAR CONTRACTURE ASSOCIATED WITH BREAST IMPLANT

Contacts and locations

Locations

Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
RECRUITING

Lille, 59000, France
Hôpital Tenon
RECRUITING

Paris, 75970, France
Institut Claudius Regaud
RECRUITING

Toulouse, 31059, France
Institut Paoli Calmette
RECRUITING

Marseille, 13009, France
Institut de Cancérologie de l'Ouest
RECRUITING

Saint-Herblain, 44805, France
Institut du Cancer de Montpellier
RECRUITING

Montpellier, 34298, France
centre Antoine Lacassagne
RECRUITING

Nice, 06189, France

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