Major trial tests cutting radiation for breast cancer – could spare thousands from side effects

NCT ID NCT05634889

Recruiting now Disease control Sponsor: Region Skane Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for women with early-stage breast cancer that has spread to 1-2 lymph nodes. It tests whether skipping radiation to the lymph nodes can reduce side effects and improve quality of life without increasing the risk of cancer coming back. About 1,350 participants will be randomly assigned to receive either standard radiation or a reduced plan that avoids lymph node treatment. The goal is to see if the gentler approach is just as effective at preventing recurrence over five years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Bergen
RECRUITING

Bergen, Norway
Bodø
NOT_YET_RECRUITING

Bodø, Norway
Gjövik
RECRUITING

Gjøvik, Norway
Helsinki University Hospital
RECRUITING

Helsinki, Finland
Kristiansand
RECRUITING

Kristiansand, Norway
Lahti Hospital
NOT_YET_RECRUITING

Lahti, Finland
Oslo
RECRUITING

Oslo, Norway
Region Gävleborg
RECRUITING

Gävle, Sweden
Region Halland
RECRUITING

Halmstad, Sweden
Region Jönköping
RECRUITING

Jönköping, Sweden
Region Kalmar län
RECRUITING

Kalmar, Sweden
Region Kronoberg
RECRUITING

Vaxjo, Sweden
Region Skåne
RECRUITING

Lund, Sweden
Region Stockholm
RECRUITING

Stockholm, Sweden
Region Sörmland
RECRUITING

Eskilstuna, 24751, Sweden
Region Uppsala
NOT_YET_RECRUITING

Uppsala, Sweden
Region Värmland
RECRUITING

Karlstad, Sweden
Region Västerbotten
RECRUITING

Umeå, Sweden
Region Västernorrland
RECRUITING

Sundsvall, Sweden
Region Västmanland
RECRUITING

Västerås, Sweden
Region Västra Götaland
RECRUITING

Gothenburg, Sweden
Region Västragötaland
RECRUITING

Borås, Sweden
Region Västragötaland
RECRUITING

Skövde, Sweden
Region Örebro
RECRUITING

Örebro, Sweden
Region Östergötland
RECRUITING

Linköping, Sweden
Stavanger
RECRUITING

Stavanger, Norway
Tromsø
RECRUITING

Tromsø, Norway
Trondheim
RECRUITING

Trondheim, Norway
Turku University Hospital
NOT_YET_RECRUITING

Turku, Finland
Ålesund
RECRUITING

Ålesund, Norway

More trials for these conditions

Other studies related to the condition(s) this trial covers.