New combo therapy aims to shrink Hard-to-Treat tumors

NCT ID NCT06953089

Recruiting now Disease control Sponsor: DualityBio Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 05, 2026 · Updated 30 times

Summary

This study tests two new drug combinations (DB-1311 with BNT327 or DB-1305) in adults with advanced or metastatic solid tumors that have not responded to prior treatments. About 492 participants will receive the drugs to see if tumors shrink and to check for side effects. The goal is to find safer, more effective options for people with limited choices.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

AUS04-0
RECRUITING

Birtinya, Queensland, 4575, Australia
AUS05-0
RECRUITING

Adelaide, South Australia, 5000, Australia
AUS06-0
RECRUITING

Benowa, Queensland, 4217, Australia
AUS07-0
RECRUITING

North Sydney, New South Wales, 2060, Australia
CHN01-0
RECRUITING

Shanghai, Shanghai Municipality, 200120, China
CHN02-0
RECRUITING

Beijing, Beijing Municipality, 100021, China
CHN04-0
RECRUITING

Hubei, Hubei, 430014, China
CHN04-0
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
CHN06-0
RECRUITING

Henan, Henan, 450008, China
CHN11-0
RECRUITING

Changsha, Hunan, 410013, China
CHN12-0
RECRUITING

Xinxiang, Henan, 453100, China
CHN13-0
RECRUITING

Beijing, Beijing Municipality, 100032, China
CHN16-0
RECRUITING

Xuzhou, Jiangsu, 221000, China
CHN17-0
RECRUITING

Dongguan, Guangdong, 523000, China
CHN23-0
RECRUITING

Beijing, Beijing Municipality, 100142, China
CHN24-0
RECRUITING

Chengdu, Sichuan, 610041, China
CHN25-0
RECRUITING

Xi'an, Shaanxi, 710061, China
CHN26-0
RECRUITING

Wuhan, Hubei, 00000, China
CHN34-0
RECRUITING

Wuhan, Hubei, 430079, China
CHN35-0
RECRUITING

Shenyang, Liaoning, 110042, China
TWN01-0
RECRUITING

Taipei, Taipei, 0, Taiwan
TWN02-0
RECRUITING

Taipei, Taipei, 23561, Taiwan
USA01-0
RECRUITING

Wheat Ridge, Colorado, 80033, United States
USA03-0
RECRUITING

Charleston, South Carolina, 29425, United States
USA04-0
RECRUITING

New York, New York, 10032, United States
USA05-0
RECRUITING

Virginia Beach, Virginia, 22031, United States
USA06-0
RECRUITING

Los Angeles, California, 90025, United States
USA07-0
RECRUITING

Spokane, Washington, 99208, United States
USA08-0
RECRUITING

Florida City, Florida, 99208, United States
USA09-0
RECRUITING

Puyallup, Washington, 98373, United States
USA10-0
RECRUITING

Atlanta, Georgia, 30318, United States
USA11-0
RECRUITING

Bethesda, Maryland, 20817, United States
USA12-0
RECRUITING

Houston, Texas, 77030, United States
USA13-0
RECRUITING

Anderson, Texas, 46011, United States
USA14-0
RECRUITING

Lincoln, Nebraska, 68506, United States
USA15-0
RECRUITING

Portland, Oregon, 97239, United States
USA16-0
RECRUITING

Los Angeles, California, 90025, United States

Conditions

Explore the condition pages connected to this study.

SOLID TUMORS SOLID TUMORS