Radiation-Free breast cancer treatment? new trial tests skipping it after chemo success
NCT ID NCT05866458
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether women with early-stage breast cancer that has not spread to lymph nodes can safely skip radiation therapy after a lumpectomy, if their tumor completely disappeared with chemotherapy. The trial will enroll 352 women and follow them for cancer recurrence in the same breast. The goal is to reduce unnecessary treatment side effects without increasing the risk of cancer coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy omission
What this could lead to
If successful, this could allow many women with early breast cancer to avoid radiation and its side effects after a good response to chemotherapy.
What could go wrong
This is a phase 3 trial, but it only includes a specific group (node-negative, complete response). The risk of cancer returning in the breast without radiation is unknown and may be higher than expected.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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BC Cancer - Centre for the North
RECRUITINGPrince George, British Columbia, V2M 7E9, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Quebec - Universite Laval
RECRUITINGQuébec, Quebec, G1R 2J6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHUM - Centre Hospitalier de L'Université de Montréal
RECRUITINGMontreal, Quebec, H2L 4M1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cancer Centre of Southeastern Ontario at Kingston
RECRUITINGKingston, Ontario, K7L 5P9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Trois Rivieres Ste-Marie
RECRUITINGTrois-Rivières, Quebec, G8Z 3R9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre hospitalier de Lanaudière
RECRUITINGSaint-Charles-Borromée, Quebec, J6E 6J2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jewish General Hospital
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Juravinski Cancer Centre
RECRUITINGHamilton, Ontario, L8V 5C2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Latrobe Regional Health
RECRUITINGTraralgon, 3844, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Liverpool Hospital
RECRUITINGLiverpool, New South Wales, 1871, Australia
Contact
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Maroondah Hospital
RECRUITINGBox Hill, 3128, Australia
Contact Email: •••••@•••••
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mater Hospital Sydney
RECRUITINGNorth Sydney, New South Wales, 2060, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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McGill University Health Centre (MUHC)
RECRUITINGMontreal, Q, H4A 3J1, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Monash Medical Centre -Moorabbin
NOT_YET_RECRUITINGBentleigh East, Victoria, 3165, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Prince of Wales Hospital
RECRUITINGRandwick, 2031, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Perth Hospital
NOT_YET_RECRUITINGPerth, 6000, Australia
Contact Email: •••••@•••••
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Victoria Regional Health Centre
RECRUITINGBarrie, Ontario, L4M 6M2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Vincent's Hospital Melbourne
RECRUITINGMelbourne, Victoria, 3065, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sunnybrook Health Sciences -Odette Cancer Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Thunder Bay Regional Health Sciences Centre
RECRUITINGThunder Bay, Ontario, P7B 6V4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tweed Valley Hospital
RECRUITINGCudgen, Cudgen, 2487, Australia
Contact
Contact Email: •••••@•••••
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Victorian Breast & Oncology Care (VBOC)
RECRUITINGEast Melbourne, Victoria, 3002, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Westmead Hospital
RECRUITINGWestmead, New South Wales, 2145, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact