New contrast mammogram may spot more cancers in dense breasts

NCT ID NCT05625659

Recruiting now Diagnosis Sponsor: American College of Radiology Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study is testing whether a special type of mammogram called contrast-enhanced spectral mammography (CESM) can find breast cancers better than the standard 3D mammogram (digital breast tomosynthesis, or DBT) in women with dense breast tissue. About 2,000 women with dense breasts will get both types of mammograms at their regular screening visit and again one year later. The goal is to see if CESM catches more cancers and leads to fewer unnecessary call-backs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: contrast-enhanced spectral mammography (CESM) with iodine-based contrast agent
What this could lead to: If successful, CESM could become a more accurate screening tool for women with dense breasts, detecting more cancers while reducing false alarms.
What could go wrong: This is a large but still early-stage comparison; CESM requires an injection of contrast dye, which carries a small risk of allergic reaction or kidney issues. The study only follows participants for one year, so long-term benefits are not yet known.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

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Locations

Boca Raton Regional Hospital - Christine E. Lynn Women's Health and Wellness Institute
RECRUITING

Boca Raton, Florida, 33486, United States
Boston Breast Diagnostic Center
RECRUITING

Wellesley Hills, Massachusetts, 02481, United States
Carolina Breast Imaging Specialists
RECRUITING

Greenville, North Carolina, 27834, United States
Henry Ford Health
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Lake Medical Imaging
ACTIVE_NOT_RECRUITING

The Villages, Florida, 32159, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
St. Joseph's Hospital
RECRUITING

London, Ontario, N6A 4V2, Canada
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University
RECRUITING

Sewell, New Jersey, 08080, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Alabama, Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22911, United States

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