New drug cocktail aims to tackle tough breast cancer
NCT ID NCT06042894
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase II trial tests two experimental drugs, SI-B003 and BL-B01D1, in people with advanced HER2-negative breast cancer that has not responded to standard treatments. The study will see if the drugs can shrink tumors and determine the best dose. About 58 participants will receive either SI-B003 alone or a combination of both drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SI-B003 (an immunotherapy drug) and BL-B01D1 (a targeted drug that delivers chemotherapy directly to cancer cells)
- What this could lead to
- If successful, this could offer a new treatment option for people with advanced HER2-negative breast cancer who have run out of standard therapies.
- What could go wrong
- This is an early phase II trial with only 58 participants, so results may not apply to everyone. The combination therapy may cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BREAST CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, China
Contact
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Chest-Injected drug drain Cancer's fluid trap?
- A dab of gel on the breathing tube might spare surgery patients a sore throat — a trial puts it to the test.
- Can a deeper nerve block ease pain after breast surgery?
- Does breast cancer radiation harm a key immune gland? a study investigates
- A web program may ease the emotional toll of chemotherapy hair loss
- Can 3D breast imaging spot more dangerous cancers than standard mammograms?