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Green dye could replace radioactive tracers in breast cancer surgery

NCT ID NCT07146295

Recruiting now Knowledge-focused Sponsor: Isabelle Henskens Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to help Dutch hospitals switch from using a radioactive tracer to a green dye called indocyanine green (ICG) to find the first lymph node that breast cancer may spread to. The dye is given during surgery, avoids radiation, and requires no extra hospital visits. Researchers will roll out the change step-by-step in several hospitals and gather feedback from patients and doctors to create a guide for nationwide use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Indocyanine green (ICG) dye
What this could lead to
If successful, this could make sentinel lymph node biopsy during breast cancer surgery safer, cheaper, and more convenient by replacing radioactive tracers with a dye given during surgery.
What could go wrong
This is an implementation study, not a test of effectiveness. ICG is already known to work as well as the standard method, so the main risk is that hospitals may not adopt it smoothly or that patient feedback reveals issues.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Lymphatic Metastasis metastatic malignant neoplasm in the lymph nodes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER FLUORESCENCE IMAGING INDOCYANINE GREEN (ICG) LYMPH NODE MAPPING LYMPHATIC METASTASIS RADIOISOTOPES SENTINEL LYMPH NODE SENTINEL LYMPH NODE BIOPSY (SLNB) SENTINEL LYMPH NODE DETECTION

Contacts and locations

Locations

  • Alrijne Hospital

    RECRUITING

    Leiden, Netherlands

  • Canisius Wilhelmina Ziekenhuis

    RECRUITING

    Nijmegen, Netherlands

  • Diakonessenhuis

    RECRUITING

    Utrecht, Netherlands

    Contact Email: •••••@•••••

  • Dijklander Ziekenhuis

    RECRUITING

    Hoorn, Netherlands

  • Noordwest Ziekenhuisgroep

    RECRUITING

    Alkmaar, Netherlands

  • Spaarne Gasthuis

    RECRUITING

    Hoofddorp, Netherlands

  • Ziekenhuisgroep Twente

    RECRUITING

    Hengelo, Netherlands

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