New hope for Hard-to-Treat breast cancer: targeted drug trial launches

NCT ID NCT06966453

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 22 times

Summary

This study tests a medicine called disitamab vedotin in people with advanced breast cancer that has HER2 on the tumor cells and has not responded well to prior treatments. About 100 adults will receive the drug as an IV infusion every two weeks. Researchers will monitor safety and whether tumors shrink, aiming to find a better option for controlling this aggressive cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ANIMI - Unidade de Tratamento Oncologico
RECRUITING

Lages, Santa Catarina, 88501001, Brazil
Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Alliance Cancer Specialists, PC
RECRUITING

Bensalem, Pennsylvania, 19020, United States
Alliance Cancer Specialists, PC
RECRUITING

Doylestown, Pennsylvania, 18901, United States
Alliance Cancer Specialists, PC
RECRUITING

Horsham, Pennsylvania, 19044, United States
Alliance Cancer Specialists, PC
RECRUITING

Langhorne, Pennsylvania, 19047, United States
Alliance Cancer Specialists, PC
RECRUITING

Media, Pennsylvania, 19063, United States
Alliance Cancer Specialists, PC
RECRUITING

Sellersville, Pennsylvania, 18960, United States
Alliance Cancer Specialists, PC
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Azienda Ospedaliero-Universitaria di Bologna IRCCS
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno
RECRUITING

Livorno, Tuscany, 57124, Italy
Banner Gateway Medical Center
NOT_YET_RECRUITING

Gilbert, Arizona, 85234, United States
Banner MD Anderson Cancer Center
NOT_YET_RECRUITING

Gilbert, Arizona, 85234, United States
Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
RECRUITING

São Caetano do Sul, São Paulo, 09541-270, Brazil
Charité University Hospital Berlin
RECRUITING

Berlin, 10117, Germany
City of Hope National Medical Center
NOT_YET_RECRUITING

Duarte, California, 91010, United States
City of Hope at Irvine Lennar
NOT_YET_RECRUITING

Irvine, California, 92618, United States
Clinical and Translational Research Unit (CTRU)
RECRUITING

Palo Alto, California, 94304, United States
Cro-Irccs
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Emory Clinic Investigational Drug Services
RECRUITING

Atlanta, Georgia, 30322, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Clearwater, Florida, 33761, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Gainesville, Florida, 32605, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Largo, Florida, 33770, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Lecanto, Florida, 34461, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Ocala, Florida, 34474, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Orange City, Florida, 32763, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Orlando, Florida, 32806, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Tallahassee, Florida, 32308, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Tampa, Florida, 33607, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Tavares, Florida, 32778, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

The Villages, Florida, 32159, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Trinity, Florida, 34655, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists
NOT_YET_RECRUITING

Winter Park, Florida, 32789, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Hospital Beata María Ana
RECRUITING

Madrid, 28007, Spain
Hospital Clinico de Valencia
RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Madrid, Comunidad de, 28046, Spain
Hospital Universitario Virgen Nieves
RECRUITING

Granada, 18012, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, Málaga, 29010, Spain
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale
RECRUITING

Naples, Campania, 80131, Italy
Kanagawa cancer center
RECRUITING

Yokohama, Kanagawa, 2418515, Japan
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung
RECRUITING

Essen, North Rhine-Westphalia, 45136, Germany
Lakeridge Health
RECRUITING

Oshawa, Ontario, L1G 2B9, Canada
Los Angeles Cancer Network
RECRUITING

Fountain Valley, California, 92708, United States
Los Angeles Cancer Network
RECRUITING

Los Angeles, California, 90017, United States
Los Angeles Cancer Network - Anaheim
RECRUITING

Anaheim, California, 92805, United States
Los Angeles Hematology Oncology Medical Group
RECRUITING

Glendale, California, 91204, United States
Los Angeles Hematology Oncology Medical Group
RECRUITING

Van Nuys, California, 91405, United States
Medstar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Mission Community Hospital (Satellite Site)
RECRUITING

Los Angeles, California, 91402, United States
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
RECRUITING

Blacksburg, Virginia, 24060, United States
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
RECRUITING

Roanoke, Virginia, 24014, United States
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
RECRUITING

Salem, Virginia, 24153, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Low Moor, Virginia, 24457, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Wytheville, Virginia, 24382, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Albany, Oregon, 97321, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Corvallis, Oregon, 97330, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Eugene, Oregon, 97401, United States
Oncology Associates of Oregon, P.C.
RECRUITING

Springfield, Oregon, 97477, United States
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Parc de Salut Mar - Hospital del Mar
RECRUITING

Barcelona, Barcelona [barcelona], 08003, Spain
Rocky Mountain Cancer Centers, LLP
RECRUITING

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Boulder, Colorado, 80303, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Centennial, Colorado, 80112, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Colorado Springs, Colorado, 80923, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Englewood, Colorado, 80113, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Longmont, Colorado, 80504, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Pueblo, Colorado, 81003, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Thornton, Colorado, 80260, United States
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, Queensland, 4029, Australia
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute - Pharmacy
RECRUITING

Nashville, Tennessee, 37203, United States
Smilow Cancer Hospital - Derby
RECRUITING

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital - Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital - Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital - Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital - Long Ridge
RECRUITING

Stamford, Connecticut, 06902, United States
Smilow Cancer Hospital - North Haven
RECRUITING

North Haven, Connecticut, 06473, United States
Smilow Cancer Hospital - Torrington
RECRUITING

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital - Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital - Waterbury
RECRUITING

Waterbury, Connecticut, 06708, United States
Smilow Cancer Hospital - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital - Yale New Haven Health
RECRUITING

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital at St. Francis
RECRUITING

Hartford, Connecticut, 06105, United States
Southern Cancer Center, PC
RECRUITING

Daphne, Alabama, 36526, United States
Southern Cancer Center, PC
RECRUITING

Foley, Alabama, 36535, United States
Southern Cancer Center, PC
RECRUITING

Mobile, Alabama, 36608, United States
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Stanford Health Care, Investigational Drug Service
RECRUITING

Stanford, California, 94305, United States
Stanford Women's Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
Swedish Medical Center
RECRUITING

Seattle, Washington, 98122, United States
Sylvester Comprehensive Cancer Center
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
Sylvester Comprehensive Cancer Center - Coral Springs
NOT_YET_RECRUITING

Coral Springs, Florida, 33065, United States
Sylvester Comprehensive Cancer Center - Hollywood
NOT_YET_RECRUITING

Hollywood, Florida, 33021, United States
Sylvester Comprehensive Cancer Center - Kendall
NOT_YET_RECRUITING

Miami, Florida, 33176, United States
Sylvester Comprehensive Cancer Center - Plantation
NOT_YET_RECRUITING

Plantation, Florida, 33324, United States
Sylvester Comprehensive Cancer Center - Sole Mia
NOT_YET_RECRUITING

North Miami, Florida, 33181, United States
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
NOT_YET_RECRUITING

Coral Gables, Florida, 33146, United States
Sylvester Comprehensive Cancer Center- Doral
NOT_YET_RECRUITING

Doral, Florida, 33166, United States
Texas Oncology - DFW
RECRUITING

Arlington, Texas, 76012, United States
Texas Oncology - DFW
RECRUITING

Arlington, Texas, 76014, United States
Texas Oncology - DFW
RECRUITING

Bedford, Texas, 76022, United States
Texas Oncology - DFW
RECRUITING

Dallas, Texas, 75203, United States
Texas Oncology - DFW
RECRUITING

Dallas, Texas, 75230, United States
Texas Oncology - DFW
RECRUITING

Dallas, Texas, 75231, United States
Texas Oncology - DFW
RECRUITING

Dallas, Texas, 75237, United States
Texas Oncology - DFW
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology - DFW
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology - DFW
RECRUITING

Grapevine, Texas, 76051, United States
Texas Oncology - DFW
RECRUITING

Plano, Texas, 75075, United States
Texas Oncology - DFW
RECRUITING

Plano, Texas, 75093, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78217, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology-Northeast Texas
RECRUITING

Allen, Texas, 75013, United States
Texas Oncology-Northeast Texas
RECRUITING

Denison, Texas, 75020, United States
Texas Oncology-Northeast Texas
RECRUITING

Denton, Texas, 76201, United States
Texas Oncology-Northeast Texas
RECRUITING

Flower Mound, Texas, 75028, United States
Texas Oncology-Northeast Texas
RECRUITING

Lewisville, Texas, 75056, United States
Texas Oncology-Northeast Texas
RECRUITING

Longview, Texas, 75601, United States
Texas Oncology-Northeast Texas
RECRUITING

McKinney, Texas, 75071, United States
Texas Oncology-Northeast Texas
RECRUITING

Palestine, Texas, 75801, United States
Texas Oncology-Northeast Texas
RECRUITING

Paris, Texas, 75460, United States
Texas Oncology-Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Koto, Tokyo, 135-8550, Japan
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan
US Oncology Investigation Products Center(IPC)
RECRUITING

Irving, Texas, 75063, United States
US Oncology Investigational Product Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
University Hospital Carl Gustav Carus, Technical University Dresden
NOT_YET_RECRUITING

Dresden, Saxony, 01307, Germany
University of Miami Hospital and Clinics
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
University of Miami Hospital and Clinics - Deerfield Beach
NOT_YET_RECRUITING

Deerfield Beach, Florida, 33442, United States
Universitätsklinikum Heidelberg
NOT_YET_RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Leipzig
NOT_YET_RECRUITING

Leipzig, 04103, Germany
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Virginia Cancer Specialists, PC
RECRUITING

Arlington, Virginia, 22201, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Cancer Specialists, PC
RECRUITING

Manassas, Virginia, 20110, United States
Virginia Cancer Specialists, PC
RECRUITING

Reston, Virginia, 20190, United States
Virginia Oncology Associates
RECRUITING

Chesapeake, Virginia, 23320, United States
Virginia Oncology Associates
RECRUITING

Newport News, Virginia, 23606, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Virginia Oncology Associates
RECRUITING

Virginia Beach, Virginia, 23456, United States
Virginia Oncology Associates
RECRUITING

Williamsburg, Virginia, 23188, United States
Waterloo Regional Health Network
RECRUITING

Kitchener, Ontario, N2G 1G3, Canada
Western Health-Sunshine & Footscray Hospitals
RECRUITING

St Albans, Victoria, 3021, Australia
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Winship Cancer Institute @ Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06520, United States
Yale University - Smilow Cancer Hospital; C/O Thomas Ferencz, RPh, BCOP
RECRUITING

New Haven, Connecticut, 06511, United States
Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

BREAST CANCER BREAST NEOPLASMS BREAST NEOPLASMS