New hope for HER2+ breast cancer: switching drug combos after treatment fails

NCT ID NCT07455188

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at what happens when people with HER2-positive advanced breast cancer switch between two different targeted therapy combinations after their first treatment stops working. About 600 women will be split into two groups: one switches from HP+chemo to HPy+chemo, the other does the opposite. The goal is to see which switch works better at controlling the cancer and helping people live longer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Zhejiang Cancer Hospital

    RECRUITING

    Zhejiang, Hangzhou, 310000, China

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Other studies related to the condition(s) this trial covers.