Yoga and PT show promise in easing pain for breast cancer patients on hormone therapy
NCT ID NCT04457895
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a program combining physical therapy, yoga, and patient education can reduce joint and muscle pain caused by hormone therapy in breast cancer patients. About 108 women with non-metastatic breast cancer and moderate-to-severe pain will be randomly assigned to either the yoga-PT program or standard care. The goal is to see if the program helps patients lower their pain and improve their quality of life.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 108 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2021
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 99 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Non metastatic breast cancer * Ongoing hormone therapy, with no treatment modification in the 30 days before inclusion * Osteoarticular and/or musculoskeletal pain due to HT ≥ 4 on the Numeric Pain Rating Scale (NPRS) * Previous treatment (surgery, chemotherapy or radiotherapy) ended at least 2 months before inclusion * Informed patient and signed informed consent received * Affiliation to a social security system Exclusion Criteria: * Chronic rhumatologic pain with specific care needed * Regular Yoga practice in the 3 months before inclusion * Contraindication or clinical state not allowing physical practice * Patient whose regular follow-up is initially impossible for psychological, family, social or geographical reasons, * Pregnant and breastfeeding woman
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
7 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CH Libourne
RECRUITINGLibourne, Aquitaine, 33500, France
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CHU Nîmes
RECRUITINGNîmes, Herault, 30029, France
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Icm Val D'Aurelle
RECRUITINGMontpellier, Herault, 34298, France
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Insitut de Cancérologie de Lorraine
RECRUITINGVandœuvre-lès-Nancy, Meurthe-et-Moselle,, 54519, France
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Institut Bergonié
RECRUITINGBordeaux, New Aquitaine, 33076, France
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Institut de Cancérologie de l'Ouest
RECRUITINGAngers, Pays de la Loire Region, 49055, France
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Institut du sein Basque
RECRUITINGTosse, New Aquitaine, 40230, France
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Other studies related to the condition(s) this trial covers.
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- Mind and body: does resilience leave a molecular mark in breast cancer?
- Which pain block works better for breast surgery?
- Can a Triple-Drug combo erase HER2-Positive breast tumors before surgery?
- Bacteria inside tumors may hold the key to breast cancer treatment
- Can a newer drug ease the bone pain of chemotherapy support?