MRI dye safety under scrutiny: landmark study tracks brain effects over 5 years

NCT ID NCT04373564

Recruiting now Knowledge-focused Sponsor: Guerbet Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether repeated doses of a gadolinium-based contrast agent (a dye used in MRI scans) affect motor and cognitive functions in healthy adults. About 2076 participants will receive annual imaging and undergo tests over 5 years. The goal is to compare changes in movement and thinking between those who get the dye and those who do not.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm colorectal cancer colorectal neoplasm hepatocellular carcinoma liver disorder neuroendocrine neoplasm pancreatic intraductal papillary-mucinous neoplasm prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE FUNCTION CONTRAST MEDIA MOTOR FUNCTION

Contacts and locations

Locations

A.O.U. Senese Policlinico Santa Maria alle Scotte
RECRUITING

Siena, Siena, 53100, Italy
ActivMed Practices & Research, Inc.
WITHDRAWN

Methuen, Massachusetts, 01844, United States
Albert Einstein Healthcare Network
RECRUITING

Philadelphia, Pennsylvania, 19141, United States
Albert Einstein Sociedade Beneficente Israelita Brasileira
RECRUITING

São Paulo, São Paulo, 05652000, Brazil
Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma)
RECRUITING

Verona, 37134, Italy
Azienda Ospedaliera Universitaria di Trieste
RECRUITING

Trieste, Trieste, 34125, Italy
BHI of Omsk region "Clinical Oncology Dispensary"
SUSPENDED

Omsk, 644013, Russia
Beth Israel Deaconess Medical Center
WITHDRAWN

Boston, Massachusetts, 02215, United States
Boston University Medical Center
TERMINATED

Boston, Massachusetts, 02118, United States
CEMEC - Oncológica
WITHDRAWN

São Bernardo do Campo, São Paulo, 09715-090, Brazil
CEMEC - Oncológica
WITHDRAWN

São Bernardo do Campo, Brazil
CHU Strasbourg - Hôpital Hautepierre
RECRUITING

Strasbourg, 67200, France
CPCLIN - Centro de Pesquisas Clínicas Ltda.
TERMINATED

São Paulo, São Paulo, 01228-200, Brazil
Chonnam National University Hospital
WITHDRAWN

Gwangju, Gyeonggi-do, 61469, South Korea
Chosun University Hospital
RECRUITING

Gwangju, 61453, South Korea
Chung-Ang University Hospital
RECRUITING

Seoul, 06973, South Korea
Department of Radiology
WITHDRAWN

St Louis, Missouri, 63110, United States
FSBI "National medical scientific center of psychiatry and neurology n.a. V.M. Bekhterev" Adolescent
SUSPENDED

Saint Petersburg, 192019, Russia
FSBI North-West Federal Medical Research Center n.a. V.A. Almazov of MoH RF
SUSPENDED

Saint Petersburg, 197341, Russia
Federal State Budgetary Scientific Institution "Tomsk National Research Medical Centre of the Russia
SUSPENDED

Tomsk, 634009, Russia
Fundação Faculdade Regional de Medicina de São José do Rio Preto
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
G. Kenneth Jansz Medical Professional Corporation
WITHDRAWN

Burlington, Ontario, L7N 3V2, Canada
Gangnam Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 06273, South Korea
Groupe Hospitalier Pitie-Salpetriere
WITHDRAWN

Paris, 75013, France
Hallym University Chuncheon Sacred Heart Hospital
WITHDRAWN

Chuncheon, Gangwon-do, 24253, South Korea
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Hospital Santa Marta
TERMINATED

Taguatinga, Federal District, 72025-110, Brazil
Inje University Busan Paik Hospital
RECRUITING

Busan, 47392, South Korea
Instituto Baía Sul de Ensino e Pesquisa (IEP)
WITHDRAWN

Florianópolis, Santa Catarina, 88020-210, Brazil
Instituto Mederi de Pesquisa e Saude
RECRUITING

Passo Fundo, Rio Grande do Sul, 99010-120, Brazil
LLC Medical Center Mart
SUSPENDED

Saint Petersburg, 199178, Russia
Liga Norte-Rio-Grandense Contra o Câncer
WITHDRAWN

Natal, Rio Grande do Norte, 59075-740, Brazil
MD Anderson Cancer Center
WITHDRAWN

Houston, Texas, 77030, United States
Massachussets General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Methodist Medical Center of Illinois
RECRUITING

Peoria, Illinois, 61637, United States
Ospedale San Raffaele
RECRUITING

Milan, 20123, Italy
Penn State Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
RSBIH "Smolensk Regional Clinical Hospital"
SUSPENDED

Smolensk, 214019, Russia
SBIH Republican Clinical Oncological Dispensary of the MoH of Republic Bashkortostan
SUSPENDED

Ufa, 450054, Russia
Scottsdale Medical Imaging, LLC
RECRUITING

Scottsdale, Arizona, 85260, United States
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
UNC School of Medicine
WITHDRAWN

Chapel Hill, North Carolina, 27599, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Tuebingen
ACTIVE_NOT_RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Massachusetts Memorial Medical Center
TERMINATED

Worcester, Massachusetts, 01655, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
Università Campus Bio-Medico di Roma
RECRUITING

Roma, 00128, Italy
Vivantes Klinikum Neukoelln
RECRUITING

Berlin, 12351, Germany
Yale University School of Medicine
WITHDRAWN

New Haven, Connecticut, 06520, United States

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