Simple cuff trick may shield hearts from chemo damage

NCT ID NCT05223413

Recruiting now Disease control Sponsor: Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether temporarily stopping blood flow in the arm with a blood pressure cuff can protect the hearts of lymphoma patients receiving chemotherapy. The procedure, called remote ischemic preconditioning, is done before each chemo session. Researchers will compare heart function in 608 patients who receive either the real procedure or a sham version to see if it reduces heart damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Remote Ischemic PreConditioning (RIPC) using a modified blood pressure cuff

What this could lead to

If it works, this could offer a simple, low-cost way to protect the heart during chemotherapy, reducing the risk of long-term heart damage.

What could go wrong

This is a proof-of-concept phase II trial, so results are still early. The procedure may not provide significant heart protection, and individual responses could vary.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer lymphoma cardiomyopathy due to anthracyclines prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTHRACYCLINE-INDUCED CARDIAC TOXICITY LYMPHOMA

Contacts and locations

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Locations

Aarhus University
RECRUITING

Aarhus, Denmark

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Amsterdam UMC
NOT_YET_RECRUITING

Amsterdam, Netherlands

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Centro Medico Teknon
RECRUITING

Barcelona, Spain

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Centro Nacional de Investigaciones Cardiovasculares (CNIC)
RECRUITING

Madrid, Spain

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Fundacion Jimenez Diaz
RECRUITING

Madrid, Spain

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Henri Becquerel
RECRUITING

Rouen, France

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Hospital Clinico Universitario de Valladolid
RECRUITING

Valladolid, Spain

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Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, Spain

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Hospital Infanta Leonor
RECRUITING

Madrid, Spain

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Hospital Jaques Monod, El Havre
NOT_YET_RECRUITING

Montivilliers, France

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Hospital Puerta de Hierro
RECRUITING

Madrid, Spain

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Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain

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Hospital Universitario Clínico San Carlos
RECRUITING

Madrid, Spain

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Hospital Universitario Príncipe de Asturias
NOT_YET_RECRUITING

Alcalá de Henares, Spain

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Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, Spain

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Hospital Universitario Ruber Juan Bravo
RECRUITING

Madrid, Spain

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Hospital Universitario Virgen de las Nieves
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Granada, Spain

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Hospital Universitario Virgen del Rocío
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Seville, Spain

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Hospital Universitario de Salamanca
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Salamanca, Spain

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Hospital Universitario la Paz
RECRUITING

Madrid, Spain

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Hospital da Luz Learning Health (GLSMED)
RECRUITING

Lisbon, Portugal

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IPO Lisboa
RECRUITING

Lisbon, Portugal

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Instituto Catalán de Oncología
RECRUITING

Barcelona, Spain

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University Hospital Duesseldorf UDUS
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Düsseldorf, Germany

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