Simple cuff trick may shield hearts from chemo damage
NCT ID NCT05223413
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether temporarily stopping blood flow in the arm with a blood pressure cuff can protect the hearts of lymphoma patients receiving chemotherapy. The procedure, called remote ischemic preconditioning, is done before each chemo session. Researchers will compare heart function in 608 patients who receive either the real procedure or a sham version to see if it reduces heart damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Remote Ischemic PreConditioning (RIPC) using a modified blood pressure cuff
- What this could lead to
- If it works, this could offer a simple, low-cost way to protect the heart during chemotherapy, reducing the risk of long-term heart damage.
- What could go wrong
- This is a proof-of-concept phase II trial, so results are still early. The procedure may not provide significant heart protection, and individual responses could vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aarhus University
RECRUITINGAarhus, Denmark
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Amsterdam UMC
NOT_YET_RECRUITINGAmsterdam, Netherlands
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Centro Medico Teknon
RECRUITINGBarcelona, Spain
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Centro Nacional de Investigaciones Cardiovasculares (CNIC)
RECRUITINGMadrid, Spain
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Fundacion Jimenez Diaz
RECRUITINGMadrid, Spain
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Henri Becquerel
RECRUITINGRouen, France
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Hospital Clinico Universitario de Valladolid
RECRUITINGValladolid, Spain
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Hospital General Universitario Gregorio Marañon
RECRUITINGMadrid, Spain
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Hospital Infanta Leonor
RECRUITINGMadrid, Spain
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Hospital Jaques Monod, El Havre
NOT_YET_RECRUITINGMontivilliers, France
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Hospital Puerta de Hierro
RECRUITINGMadrid, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Spain
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Hospital Universitario Clínico San Carlos
RECRUITINGMadrid, Spain
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Hospital Universitario Príncipe de Asturias
NOT_YET_RECRUITINGAlcalá de Henares, Spain
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Hospital Universitario Ramon y Cajal
RECRUITINGMadrid, Spain
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Hospital Universitario Ruber Juan Bravo
RECRUITINGMadrid, Spain
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Hospital Universitario Virgen de las Nieves
RECRUITINGGranada, Spain
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Hospital Universitario Virgen del Rocío
RECRUITINGSeville, Spain
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Hospital Universitario de Salamanca
RECRUITINGSalamanca, Spain
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Hospital Universitario la Paz
RECRUITINGMadrid, Spain
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Hospital da Luz Learning Health (GLSMED)
RECRUITINGLisbon, Portugal
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IPO Lisboa
RECRUITINGLisbon, Portugal
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Instituto Catalán de Oncología
RECRUITINGBarcelona, Spain
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University Hospital Duesseldorf UDUS
RECRUITINGDüsseldorf, Germany
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