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New targeted drug shows promise for Hard-to-Treat breast cancers

NCT ID NCT05307705

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This early-stage study tests a new drug called LOXO-783 in people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The main goals are to find the safest dose and check for side effects. About 193 participants will take the drug alone or with other cancer treatments for up to 3 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

  • Aichi Cancer Center Hospital

    RECRUITING

    Nagoya, 464-8681, Japan

  • Asan Medical Center

    NOT_YET_RECRUITING

    Seoul, 5505, South Korea

  • BC Cancer Vancouver

    RECRUITING

    Vancouver, V5Z4E6, Canada

  • Beijing Cancer hospital

    NOT_YET_RECRUITING

    Beijing, 100036, China

  • Cancer Research SA

    NOT_YET_RECRUITING

    Adelaide, 5000, Australia

  • Centre Leon Berard

    RECRUITING

    Lyon, 69373, France

  • Dana-Farber Cancer Institute

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Fudan University Shanghai Cancer Center

    RECRUITING

    Shanghai, 200032, China

  • Gustave Roussy

    NOT_YET_RECRUITING

    Villejuif, 94805, France

  • Hospital Arnau de Vilanova Valencia

    RECRUITING

    Valencia, 46015, Spain

  • Hospital Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

  • Hospital General Universitario Gregorio Maranon

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Quironsalud Madrid

    RECRUITING

    Pozuelo de Alarcón, 28223, Spain

  • Hospital Universitari Vall d'Hebron

    NOT_YET_RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    NOT_YET_RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Quiron Dexeus

    RECRUITING

    Barcelona, 08028, Spain

  • ICANS_Institut de Cancerologie Strasbourg Europe

    RECRUITING

    Strasbourg, 67033, France

  • Institut Curie

    NOT_YET_RECRUITING

    Paris, 75248, France

  • Institut Jules Bordet

    NOT_YET_RECRUITING

    Anderlecht, 1070, Belgium

  • Institut de Cancérologie de l'Ouest

    RECRUITING

    Saint-Herblain, 44805, France

  • Kyoto University Hospital

    NOT_YET_RECRUITING

    Kyoto, 606-8507, Japan

  • Massachusetts General Hospital

    COMPLETED

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    NOT_YET_RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905-0002, United States

  • Mayo Clinic of Scottsdale

    NOT_YET_RECRUITING

    Scottsdale, Arizona, 85259, United States

  • Memorial Sloan Kettering Cancer Center

    COMPLETED

    New York, New York, 10065, United States

  • National Cancer Center Hospital

    RECRUITING

    Chūōku, 104-0045, Japan

  • National Cancer Centre Singapore

    NOT_YET_RECRUITING

    Singapore, 169610, Singapore

  • Peter Maccallum Cancer Institute Erb

    NOT_YET_RECRUITING

    East Melbourne, 3002, Australia

  • Princess Margaret Hospital (Hong Kong)

    RECRUITING

    Toronto, M5G 2M9, Canada

  • Royal Marsden Hospital (Sutton)

    NOT_YET_RECRUITING

    Sutton, SM2 5PT, United Kingdom

  • Royal Marsden NHS Trust

    RECRUITING

    London, SW3 6JJ, United Kingdom

  • Samsung Medical Center

    NOT_YET_RECRUITING

    Seoul, 06351, South Korea

  • South Texas Accelerated Research Therapeutics (START)

    NOT_YET_RECRUITING

    San Antonio, Texas, 78229, United States

  • St Vincent's Hospital

    NOT_YET_RECRUITING

    Sydney, 2010, Australia

  • Stanford University Hospital

    RECRUITING

    Stanford, California, 94305, United States

  • Tennessee Oncology PLLC

    COMPLETED

    Nashville, Tennessee, 37203, United States

  • Texas Oncology-Baylor Charles A. Sammons Cancer Center

    NOT_YET_RECRUITING

    Dallas, Texas, 75246, United States

  • The Cancer Institute Hospital of JFCR

    RECRUITING

    Kōtō City, 135-8550, Japan

  • The Third Hospital of Nanchang

    RECRUITING

    Nanchang, 330009, China

  • UCLA Medical Center

    COMPLETED

    Los Angeles, California, 90095, United States

  • UCSF Medical Center at Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390-8884, United States

  • Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg

    NOT_YET_RECRUITING

    Leuven, 3000, Belgium

  • University of Texas MD Anderson Cancer Center

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

  • Universitätsklinikum Erlangen

    NOT_YET_RECRUITING

    Erlangen, 91054, Germany

  • Washington University Medical School

    NOT_YET_RECRUITING

    St Louis, Missouri, 63110, United States

  • Wilmot Cancer Institute

    NOT_YET_RECRUITING

    Rochester, New York, 14642, United States

  • Winship Cancer Center Emory University

    COMPLETED

    Atlanta, Georgia, 30322, United States

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