Could a tailored screening schedule beat annual mammograms?
NCT ID NCT02620852
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares annual mammograms to a personalized screening schedule based on each woman's breast cancer risk. Participants choose or are assigned to either annual screening or risk-based screening, which uses genetic testing and personal history. The goal is to see if personalized screening reduces false positives and overdiagnosis while still catching cancers early. The study aims to enroll 100,000 women aged 30-74 across the United States.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
risk assessment and genetic testing
What this could lead to
If successful, this could lead to a smarter, personalized breast cancer screening approach that reduces unnecessary biopsies and anxiety.
What could go wrong
This is a large observational study, not a treatment trial. Results may not change current guidelines quickly, and personalized screening might miss some cancers.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Edith Sanford Breast Center
ACTIVE_NOT_RECRUITINGSioux Falls, South Dakota, 57117, United States
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Louisiana State University
ACTIVE_NOT_RECRUITINGNew Orleans, Louisiana, 70112, United States
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TopLine MD Alliance
RECRUITINGMiami, Florida, 33173, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
Contact
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Davis
RECRUITINGSacramento, California, 95817, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Irvine
RECRUITINGIrvine, California, 92618, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of California Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Diego
RECRUITINGSan Diego, California, 92093, United States
Contact
Contact
Contact Email: •••••@•••••
Contact
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University of California San Francisco
RECRUITINGSan Francisco, California, 94115, United States
Contact Email: •••••@•••••
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact
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Weill Cornell Medicine
RECRUITINGNew York, New York, 10021, United States
Contact