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Could a tailored screening schedule beat annual mammograms?

NCT ID NCT02620852

Recruiting now Prevention Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares annual mammograms to a personalized screening schedule based on each woman's breast cancer risk. Participants choose or are assigned to either annual screening or risk-based screening, which uses genetic testing and personal history. The goal is to see if personalized screening reduces false positives and overdiagnosis while still catching cancers early. The study aims to enroll 100,000 women aged 30-74 across the United States.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
risk assessment and genetic testing
What this could lead to
If successful, this could lead to a smarter, personalized breast cancer screening approach that reduces unnecessary biopsies and anxiety.
What could go wrong
This is a large observational study, not a treatment trial. Results may not change current guidelines quickly, and personalized screening might miss some cancers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma in situ breast neoplasm ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CANCER SCREENING BREAST CARCINOMA IN SITU

Contacts and locations

Locations

  • Edith Sanford Breast Center

    ACTIVE_NOT_RECRUITING

    Sioux Falls, South Dakota, 57117, United States

  • Louisiana State University

    ACTIVE_NOT_RECRUITING

    New Orleans, Louisiana, 70112, United States

  • TopLine MD Alliance

    RECRUITING

    Miami, Florida, 33173, United States

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • University of California Davis

    RECRUITING

    Sacramento, California, 95817, United States

  • University of California Irvine

    RECRUITING

    Irvine, California, 92618, United States

  • University of California Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

  • University of California San Diego

    RECRUITING

    San Diego, California, 92093, United States

    Contact Email: •••••@•••••

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94115, United States

  • University of Chicago

    RECRUITING

    Chicago, Illinois, 60637, United States

  • Weill Cornell Medicine

    RECRUITING

    New York, New York, 10021, United States

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