Scientists hunt for the cause of 'Chemobrain' in breast cancer survivors
NCT ID NCT05740787
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to understand why some breast cancer patients experience 'chemobrain'—problems with memory, concentration, and thinking after chemotherapy. Researchers will track 50 patients before, during, and after chemo using brain scans, blood tests, and thinking tests. They hope to find links between brain inflammation and cognitive changes, which could lead to future treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could point toward ways to prevent or treat chemobrain in breast cancer patients.
- What could go wrong
- This is a small, early-stage observational study (50 people) that only looks for links—it does not test any treatment. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2022
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients diagnosed with Breast Cancer who have been prescribed adjuvant or neo-adjuvant chemotherapy
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women and men \>18 years * Diagnosed with HER2 negative breast cancer * Receiving EC-Taxane or Taxane only based chemotherapy * Able to communicate in English * Willing and able to give informed consent for participation in the study. Exclusion Criteria: * Any patient whose physical condition will preclude them from lying still for the duration of the brain scan. * pre-excisting mental condition/disability * Contraindication to magnetic resonance scanning such as an implantable cardiac device.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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NHS Grampian
RECRUITINGAberdeen, United Kingdom
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