New drug cocktail targets hard-to-treat stomach cancer before surgery
NCT ID NCT07569068
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a targeted drug (LM-302) to standard immunotherapy and chemotherapy before surgery can improve outcomes for people with a specific type of stomach cancer that has a protein called claudin 18.2. About 88 adults with advanced but removable stomach cancer will be randomly assigned to one of two treatment combinations. The main goal is to see how many patients have no cancer left in their removed tissue.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tislelizumab, LM-302, S-1, and oxaliplatin
- What this could lead to
- If successful, this could offer a more effective pre-surgery treatment for a specific type of stomach cancer, potentially improving the chance of complete tumor removal.
- What could go wrong
- This is an early Phase 2 exploratory study with only 88 participants, so results may not apply broadly. The combination therapy may cause more side effects than standard treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
RECRUITINGShanghai, Huangpu District, 200025, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.