Immunotherapy combo aims to stop stomach cancer return after surgery

NCT ID NCT05180734

Ongoing Disease control Sponsor: Shanghai Junshi Bioscience Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy after stomach cancer surgery can help prevent the cancer from coming back. About 878 patients who had their stomach cancer completely removed will receive either toripalimab plus chemotherapy or a placebo plus chemotherapy. The study focuses on patients with PD-L1 positive tumors and measures how long they remain cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: toripalimab (an immunotherapy drug) combined with chemotherapy
What this could lead to: If successful, this combination could become a new standard treatment after stomach cancer surgery, helping to delay or prevent the cancer from coming back.
What could go wrong: This is an early-phase trial, and the results may not show a clear benefit. Immunotherapy can cause side effects like inflammation in healthy organs, and not all patients respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC OR ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA

Contacts and locations

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Locations

Affiliated Cancer Hospital and Institute of Ghuangzhou Medical University

Guangzhou, Guangdong, 510095, China
Affiliated Hospital of Jining Medical University

Jining, Shangdong, 272007, China
Affiliated Hospital of Zunyi Medical University

Zunyi, Guizhou, 563099, China
Beijing Cancer hospital

Beijing, Beijing Municipality, 510515, China
Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China
Beijing Hospital

Beijing, Beijing Municipality, 100005, China
Cancer Hospital affiliated to Xinjiang Medical University

Ürümqi, Xinjiang, 830000, China
China-Japan Union Hospital of Jilin University

Changchun, Jilin, 130033, China
Chinese PLA General Hospital

Beijing, Beijing Municipality, 100000, China
Fujian Provincial Cancer Hospital

Fuzhou, Fujian, 350011, China
Gansu Provincial Cancer Hospital

Lanzhou, Gansu, 730050, China
Gansu Provincial People's Hospital

Lanzhou, Gansu, 730000, China
General Hospital of Ningxia Medical University

Yinchuan, Ningxia, 750000, China
Guandong General Hospital

Guangzhou, Guandong, 510000, China
Guangxi Medical University Affiliated Tumor Hospital

Nanning, Guangxi, 530021, China
Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, 150081, China
Henan cancer hospital

Zhengzhou, Henan, 450003, China
Hubei Cancer Hospital

Wuhan, Hubei, 430079, China
Hunan Cancer Hopital

Changsha, Hunan, 410031, China
Jiangmen Central Hospital

Nanchang, Jiangxi, 330006, China
Jiangsu Province Hospital

Nanjing, Jiangsu, 210029, China
Jiangsu cancer hospital

Nanjing, Jiangsu, 210000, China
Jinan Central Hospital

Jinan, Shangdong, 250012, China
Lanzhou University Second Hospital

Lanzhou, Gansu, 730000, China
LiaoNing Cancer Hospital & Institute

Shenyang, Liaoning, 110000, China
Linyi Cancer Hospital

Linyi, Shandong, 276002, China
Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, 510515, China
Nantong Tumor Hospital

Nantong, Jiangsu, 226006, China
Peking University People's hospital

Beijing, Beijing Municipality, 100044, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518000, China
Qingdao central medical group

Qingdao, Shandong, 266042, China
Qinghai University Affiliated Hosptial

Xining, Qinghai, 810000, China
Shandong Cancer Hospital

Jinan, Shandong, 250117, China
Shandong Provincial Hospital

Jinan, Shangdong, 250031, China
Shanghai General Hospital

Shanghai, Shanghai Municipality, 200080, China
Shanxi Provincial People's Hospital

Taiyuan, Shanxi, 030012, China
Shenzhen People's Hospital

Shenzhen, Guangdong, 518000, China
SiChuan Cancer Hospital

Chengdu, Sichuan, 610000, China
Suining Central Hospital

Suining, Sichuan, 629000, China
Tangdu hospital, Air force Military Medical University

Xian, Shanxi, 710000, China
The 2ed Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150086, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266003, China
The First Affiliated Hospital of Bengbu Medical College

Bengbu, Anhui, 233300, China
The First Affiliated Hospital of Henan University of science and Technology

Luoyang, Henan, 450052, China
The First Affiliated Hospital of Sun yat-sen University

Guangzhou, Guangdong, 510080, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361003, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Hospital of China Medical University

Shengyang, Liaoning, 110000, China
The First Hospital of Jiaxing

Jiaxing, Zhejiang, 314001, China
The First Hospital of Jilin University

Changchun, Jilin, 130021, China
The First People's Hospital of Changzhou

Changzhou, Jiangsu, 213004, China
The First People's Hospital of Foshan

Foshan, Guangdong, 528000, China
The Fourth Hospital of Hebei Medical University

Shijiazhuang, Hebei, 050011, China
The Peple's Hospital of Chizhou

Chizhou, Anhui, China
The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The Second Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, 325024, China
The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310009, China
The Second People's Hospital of Wuxi

Wuxi, Jiangsu, 214001, China
The first Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The first Hospital of Lanzhou University

Lanzhou, Gansu, 750050, China
The first affiliated hospital of Zhejiang medical university

Hangzhou, Zhejiang, China
The first affiliated hospital of chongqing medical universit

Chongqing, Chongqing Municipality, 400016, China
Union Hospital, Tongji Medical College,Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China
Wuwei Cancer Hospital of Gansu Province

Wuwei, Gansu, 733000, China
Xiangya Hospital Central South University

Changsha, Hunan, 410008, China
Xiangyang Central Hospital

Xiangyang, Hubei, 441021, China
Xijing hospital, Air force Military Medical University

Xian, Shanxi, 710000, China
Yichang Central People's Hospital

Yichang, Hubei, 443008, China
Yuebei People's Hospital

Shaoguan, Guangdong, 512099, China
Zhongshan Hospital, Fudan university

Shanghai, Shanghai Municipality, 200032, China
Zhujiang Hospital of Southern Medical University

Guangzhou, Guandong, 510280, China

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