Ruijin Hospital

This study compares a one-week ultra-hypofractionated radiation regimen (26 Gy in 5 fractions) to the standard three-week moderate hypofractionated regimen (40 Gy in 15 fractions) for treating lymph nodes after breast cancer surgery. The goal is to see if the shorter course is ju…

This study tests whether deep brain stimulation (DBS) can help people with schizophrenia whose symptoms haven't improved with medication. First, doctors map the brain using electrodes to find the problem areas. Then, they implant a device that delivers mild electrical pulses to t…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This early-phase trial tests an experimental drug called ES502 in people with advanced pancreatic cancer that has a specific genetic change (RAS G12V) and who have run out of standard treatments. ES502 is a lab-made protein designed to guide the body's immune T-cells to attack ca…

This study looks at whether a lower dose of radiation can safely prevent cancer from returning in people with early-stage nasal-type NK/T-cell lymphoma who have already had a complete response to chemotherapy. Participants receive 45 Gy of radiation over five weeks, targeting the…

This study tests a new drug called sonrotoclax combined with standard chemotherapy and other targeted medicines for adults newly diagnosed with acute myeloid leukemia (AML). About 205 participants will receive different treatments based on their genetic markers. The goal is to se…

This study tests a daily pill called ivosidenib in about 20 adults with a specific genetic form of acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) who cannot receive a stem cell transplant. The goal is to see if the drug can keep the cancer from coming ba…

This phase 2 trial is testing a combination of four drugs (HRS-4642, gemcitabine, albumin-bound paclitaxel, and adebrelimab) as treatment for pancreatic cancer before and after surgery. The goal is to see if this approach is safe and effective at shrinking tumors and improving su…

This phase 2 trial is testing whether adding the experimental drug HRS-4642 to standard chemotherapy (gemcitabine and albumin-bound paclitaxel) can help shrink pancreatic tumors before surgery and prevent recurrence afterward. About 30 adults with resectable or borderline resecta…

This phase 3 trial is testing whether 4 cycles of R-CHOP followed by 4 cycles of rituximab is as safe and effective as the standard 6 cycles of R-CHOP plus 2 cycles of rituximab for people with newly diagnosed, low-risk diffuse large B-cell lymphoma. The study plans to enroll 640…

This study tests a combination of four drugs (polatuzumab vedotin, zanubrutinib, lenalidomide, and glofitamab) in 30 older patients (70+) newly diagnosed with large B-cell lymphoma who are too frail for standard chemo. The goal is to see if this gentler regimen can control the ca…

This study tests whether adding a targeted drug (LM-302) to standard immunotherapy and chemotherapy before surgery can improve outcomes for people with a specific type of stomach cancer that has a protein called claudin 18.2. About 88 adults with advanced but removable stomach ca…

This study tests a combination of drugs (LM-302, S-1, and intraperitoneal paclitaxel) with or without another drug (cadonilimab) in people with a specific type of advanced stomach cancer (Claudin 18.2-positive) that has spread to the lining of the abdomen. The goal is to see if t…

This study tests whether a stem cell transplant from a donor can help people with a high-risk type of acute myeloid leukemia (AML) stay cancer-free longer. Participants receive the transplant after initial chemotherapy. The trial tracks survival, relapse, and side effects in 90 n…

This study compares two medications, firsekibart and anakinra, to see which works better and is safer for people with Adult-Onset Still's disease (AOSD). The trial will enroll 20 adults aged 18 to 75 who have been diagnosed with AOSD. The main goal is to see how many patients ach…

This study looks at the best length of treatment with the drug maribavir for a hard-to-treat CMV infection that can happen after a stem cell transplant. About 218 adults who have already had a transplant and have this infection will be randomly assigned to different treatment dur…

This study tests a new treatment for pancreatic cancer that has spread to the liver. Doctors deliver a mix of sodium bicarbonate (baking soda), chemotherapy drugs, and an immunotherapy drug directly into the liver's blood supply. The goal is to see if this approach helps people l…

This study tests whether two drugs, sintilimab and bevacizumab, given after surgery can prevent cancer from coming back in people with ruptured liver cancer. About 35 participants will receive the combination every three weeks. The goal is to see if this approach is safe and impr…

This Phase 2 trial tests a personalized approach to treating marginal zone lymphoma, a slow-growing blood cancer. Researchers assign patients to different drug combinations based on their risk score, using targeted therapies like obinutuzumab, orelabrutinib, and lenalidomide. The…

This early-stage study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy works by directing the body's immune cells to attack and control overactive immune cells causing the disease. The study will…

This study is for people with early-stage nasal-type NK/T-cell lymphoma who have not had treatment before. It tests a personalized approach using a PD-1 antibody (a type of immunotherapy) combined with radiation therapy. The goal is to improve disease control while reducing side …

This phase 2 trial is testing a combination of four drugs—cadonilimab, LM-302, S-1, and paclitaxel—in 40 people with a specific type of advanced stomach cancer (Claudin 18.2-positive) that has spread to the lining of the abdomen. The drugs are given through a vein and directly in…

This study is testing a less invasive treatment for a serious tear in the main artery near the heart, specifically for people who are too high-risk for open-heart surgery. About 149 participants will receive a stent placed through a blood vessel to repair the tear. Researchers wi…

This early-stage trial tests a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how much drug reaches the lungs and blood, and whether it is safe. Researchers hope that inhaling the drug wi…

This study tests a new way to replace the aortic valve in people with severe aortic regurgitation (a leaky heart valve). About 180 patients will get either the new VitaFlow valve or another device through a tube in the leg. The goal is to see if the new valve is safe and effectiv…

This study tests a new way to treat a rare type of nasal lymphoma (NK/T cell lymphoma) by using PET scans and blood tests for the Epstein-Barr virus to decide the best treatment plan. About 89 newly diagnosed patients will receive a combination of chemotherapy, radiation, and imm…

This phase 3 trial tests whether a chemotherapy combination of oxaliplatin plus S-1 works as well as or better than docetaxel plus S-1 for stage III gastric cancer patients who have had surgery. About 387 adults aged 18 to 80 will be randomly assigned to one of the two treatments…

This early-stage study tests a new treatment called RXIM002 for people with severe autoimmune diseases that haven't responded to standard therapies. The treatment uses a special RNA molecule to create immune cells that target and destroy faulty B cells, which are causing the dise…

This study tests a procedure called cryoablation, which uses extreme cold to freeze and destroy lung nodules that are early-stage cancer. It is for people who cannot have surgery due to age or health issues. The trial will enroll 90 participants and follow them for up to 5 years …

This study is testing whether giving a special immune cell treatment (CAR-T) right after a stem cell transplant can help people with aggressive B-cell lymphoma that has not responded to standard treatments. The trial will enroll 16 people and measure how many achieve complete rem…

This study tests whether taking a low dose of colchicine (a medicine used for gout) every day for a year can prevent the new blood vessels created during heart bypass surgery from failing. About 100 adults who recently had bypass surgery will take colchicine or no extra treatment…

This study tests a new approach for people with locally advanced pancreatic cancer whose first chemotherapy (AG) has stopped working. The treatment combines a procedure called irreversible electroporation (IRE), which uses electric pulses to destroy cancer cells, with an investig…

This phase 2 trial tests a two-pronged approach for locally advanced pancreatic cancer that has stopped responding to standard chemotherapy. First, doctors freeze the tumor using cryoablation, then give patients an experimental antibody called Apalulizumab that targets two immune…

This study is testing a combination of three drugs—orelabrutinib, lisaftoclax, and rituximab—in people with untreated, high-risk mantle cell lymphoma (MCL). The goal is to see how well this treatment shrinks or eliminates cancer. The trial will enroll 25 participants and track re…

This study tests whether adding drugs tailored to a patient's tumor genetics can improve standard chemotherapy for untreated diffuse large B-cell lymphoma. About 152 adults with intermediate-to-high risk disease will receive either the standard Pola-RCHP regimen or a version with…

This early-phase study tests a personalized mRNA vaccine (XP-004) combined with a PD-1 inhibitor in 20 patients who cannot tolerate chemotherapy after pancreatic cancer surgery. The goal is to see if the treatment is safe and can train the immune system to fight remaining cancer …

This study tests a combination of two drugs (orelabrutinib and rituximab) in people newly diagnosed with a type of blood cancer called mantle cell lymphoma that is not high-risk. Some participants may also receive a stem cell transplant using their own cells. The goal is to see h…

This study is for people with locally advanced rectal cancer that hasn't spread. It tests whether adding an immunotherapy drug (PD-1 inhibitor) to a standard treatment plan (short-course radiation plus chemotherapy and targeted therapy) can lead to a complete disappearance of the…

This study tests a combination of three drugs—orelabrutinib, selinexor, and a chemotherapy drug—in 25 people with relapsed or refractory central nervous system lymphoma, a type of brain cancer. The goal is to see if this mix can shrink tumors better than current treatments. Parti…

This phase 2 trial tests whether adding an immunotherapy drug (serplulimab) to standard chemotherapy before surgery can improve outcomes for people with locally advanced colon cancer. About 56 participants will receive the combination, then undergo surgery. The main goal is to se…

This early-stage trial tests a new treatment called PDR-001 for Parkinson's disease. It uses a harmless virus to deliver a peptide into a specific brain area, aiming to clear toxic protein clumps that cause the disease. The study will enroll 12 people with early Parkinson's to ch…

This study tests whether a special PET/MR scan can tell which fatty deposits in the neck arteries are likely to cause a stroke. About 100 adults with known carotid plaque will get two types of PET tracers along with MRI to measure inflammation and scarring inside the plaque. Rese…

This study is developing an artificial intelligence system that can recognize different parts of the throat and nasal passages and detect abnormal growths or lesions. Researchers will train the AI using thousands of endoscopy images and then test its accuracy against doctors with…

This study is testing a new type of PET scan tracer (68Ga-FAPI) to see if it can better detect lung and kidney problems in people with ANCA-associated vasculitis, a rare autoimmune disease. The tracer targets specific cells linked to tissue scarring. Researchers will enroll 30 ad…

This study tests whether a non-invasive brain-computer interface combined with 40Hz audio-visual stimulation can improve cognitive function in people with Alzheimer's disease. 90 participants will be randomly assigned to receive either fixed 40Hz stimulation, personalized closed-…

This study follows 640 participants—including people with Parkinsonism, those with REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers will use brain scans, movement tests, voice analysis, and other tools to track how the disease progresses and improve di…

This study tests whether an artificial intelligence (AI) system can automatically guide a robotic bronchoscope to the right spot in the lungs, without needing a doctor to manually align the images. Twenty adults with suspicious lung nodules will have the procedure using the Langh…

This study looks at whether measuring blood flow in the stomach and intestines can help predict feeding intolerance in critically ill patients. Researchers will monitor 500 ICU patients receiving tube feeding and track symptoms like vomiting, bloating, or diarrhea. The goal is to…

This study looks at whether a deep inspiration breath-hold (DIBH) technique during radiation therapy for breast cancer keeps the radiation dose on target and protects nearby organs. About 25 women who have had breast cancer surgery will be observed. The goal is to see if the plan…

This study is following 700 people with Parkinson's disease or multiple system atrophy in Shanghai. Researchers will collect medical history, brain scans, blood samples, and other data every six months. The goal is to find early signs of these diseases and better predict how they…

This study looks at whether walking patterns measured by wearable sensors can predict how well deep brain stimulation (DBS) will work for people with dystonia, a movement disorder. About 50 adults scheduled for DBS surgery will wear sensors before the procedure. Researchers will …