New cocktail of drugs takes on pancreatic cancer

NCT ID NCT07131514

Recruiting now Disease control Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a combination of four drugs (HRS-4642, gemcitabine, albumin-bound paclitaxel, and adebrelimab) as treatment for pancreatic cancer before and after surgery. The goal is to see if this approach is safe and effective at shrinking tumors and improving survival. The study plans to enroll 30 adults with resectable or borderline resectable pancreatic cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HRS-4642 combined with gemcitabine, albumin-bound paclitaxel, and adebrelimab
What this could lead to: If successful, this could lead to a more effective treatment approach for pancreatic cancer, potentially improving survival and reducing recurrence after surgery.
What could go wrong: This is a small, early-phase trial with only 30 participants, so results may not apply to everyone. The drug combination may cause significant side effects, and it is not yet proven to work better than standard treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER

Contacts and locations

Locations

Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, China

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