New cocktail of drugs targets Hard-to-Treat stomach cancer
NCT ID NCT06519591
First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This phase 2 trial is testing a combination of four drugs—cadonilimab, LM-302, S-1, and paclitaxel—in 40 people with a specific type of advanced stomach cancer (Claudin 18.2-positive) that has spread to the lining of the abdomen. The drugs are given through a vein and directly into the abdomen to attack the cancer from multiple angles. The main goal is to see if this approach improves survival after one year and shrinks tumors enough to allow surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cadonilimab, LM-302, S-1, and paclitaxel
- What this could lead to
- If successful, this could offer a new treatment option for people with advanced gastric cancer that has spread to the lining of the abdomen, potentially improving survival and enabling surgery.
- What could go wrong
- This is an early-phase trial with only 40 participants, so results may not apply to everyone. The drug combination may cause significant side effects, and it is not yet known if it works better than standard treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
RECRUITINGShanghai, Huangpu District, 200025, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New radiation technique targets stomach and ovarian cancer spread without surgery
- New chemo spray aims to ease suffering from abdominal cancer spread
- New chemo spray shows promise for Hard-to-Treat abdominal cancers
- New hope for stomach cancer patients with abdominal spread
- Could chemo around surgery beat cancer spread in the belly?