Laser zaps heart calcium to help stents stick
NCT ID NCT06181240
First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times
Summary
This study tests a new laser-based device that breaks up calcium deposits in the heart's arteries before placing a stent. About 426 adults with coronary artery disease will receive the treatment. The goal is to see if the device safely improves stent delivery and reduces complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- laser-based intravascular lithotripsy device
- What this could lead to
- If successful, this device could offer a new way to safely treat heavily calcified coronary arteries, potentially improving outcomes for patients needing stents.
- What could go wrong
- This is an early, single-arm study without a comparison group, so results may not prove superiority over existing treatments. Risks include heart complications during or after the procedure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aarhus University Hospital
Aarhus, 8200, Denmark
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Amsterdam University Medical Center
Amsterdam, 1105 AZ, Netherlands
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Austin Heart Research
Austin, Texas, 78756, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 021114, United States
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Cedars-Sinai Heart Institute
Los Angeles, California, 90048, United States
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Cellitinnen Krankenhaus St. Vinzenz
Cologne, 50733, Germany
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Chippenham Johnson Willis Hospital
Richmond, Virginia, 23235, United States
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Erasmus Medical Center
Rotterdam, Netherlands
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HCA FL Memorial Hospital
Jacksonville, Florida, 32216, United States
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HCA Florida Largo Hospital
Largo, Florida, 33770, United States
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Harefield Hospital
Harefield, UB9 6JH, United Kingdom
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Intermountain Health
Murray, Utah, 84107, United States
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King's College Hospital
London, SE5 9RS, United Kingdom
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Klaipeda University Hospital
Klaipėda, 92288, Lithuania
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Los Robles Hospital & Medical Center
Thousand Oaks, California, 91360, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical Center of the Rockies
Loveland, Colorado, 80538, United States
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Methodist Healthcare Methodist Research Institute
San Antonio, Texas, 78229, United States
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Metropolitan Heart and Vascular Institute
Coon Rapids, Minnesota, 55433, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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NC Heart and Vascular Research
Raleigh, North Carolina, 27607, United States
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New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York, 11215, United States
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North Mississippi Medical Center
Tupelo, Mississippi, 38801, United States
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Northeast Georgia Medical Center
Gainesville, Georgia, 30501, United States
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Nova Clinical Research Centers/Manatee Memorial Hospital
Bradenton, Florida, 34208, United States
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Nyph/Cuimc
New York, New York, 10032, United States
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Onze-Lieve-Vrouwziekenhuis, afgekort OLV ziekenhuis
Aalst, 9300, Belgium
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Providence Heart Institute
Portland, Oregon, 97225, United States
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Riverside Community Hospital
Riverside, California, 92501, United States
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Royal Brompton Hospital
London, SW3 6NP, United Kingdom
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Royal Free Hospital
London, NW3 2AG, United Kingdom
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SJG St. Paulus GmbH, St.-Johannes-Hospital Dortmund
Dortmund, 44137, Germany
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Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64131, United States
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Scripps Health
La Jolla, California, 92121, United States
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Segeberger Kliniken GmbH,
Bad Segeberg, 23795, Germany
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Southern California Permanente Medical Gp. / Kaiser Permanente
San Diego, California, 92123, United States
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St George's University of London
London, SW17 0RE, United Kingdom
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St. Thomas' Hospital
London, SE1 7EH, United Kingdom
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The Cardiac & Vascular Institute
Gainesville, Florida, 32605, United States
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The Icahn School of Medicine at Mt. Sinai
New York, New York, 10029, United States
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The Valley Hospital
Paramus, New Jersey, 07652, United States
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Trinity Health Michigan Heart
Ypsilanti, Michigan, 48197, United States
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Tristar Centennial Medical Center
Nashville, Tennessee, 37203, United States
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Vilnius University Hospital Santaros Klinikos
Vilnius, 08661, Lithuania
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Wellspan York Hospital
York, Pennsylvania, 10403, United States
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Wellstar Research Institute
Hiram, Georgia, 30141, United States
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