CORONARY ARTERY DISEASE

This study looks at how well different drug-eluting stents work in real-world patients with coronary artery disease. Researchers are comparing newer stents to older ones to see which are safest and most effective. The study includes up to 50,000 people who need a stent to open bl…

This phase 2 trial is testing whether a supplement called nicotinamide mononucleotide (NMN) can protect the heart and kidneys of people undergoing coronary artery bypass surgery. Researchers will give NMN or a placebo to 90 adults at higher risk of complications. The main goal is…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study is tracking 2,000 people with coronary artery disease who receive Ultimaster stents during routine care. Researchers want to see how often serious heart problems like death, heart attack, or the need for another procedure happen within a year. The goal is to understand…

This study is testing a new heart stent called Coroflex ISAR NEO in 1,000 people with narrowed heart arteries. The goal is to see how safe and effective it is compared to other stents in everyday medical practice. Researchers will track major heart problems like death, heart atta…

This study compares two medicated stents (tiny mesh tubes) used to open blocked heart arteries in people having a heart attack or unstable angina. About 2,100 participants will receive either a sirolimus-eluting stent (ihtDEStiny) or an everolimus-eluting stent (Xience). Research…

This study is testing a paclitaxel-coated balloon to open small coronary arteries in people with heart disease who also have a high risk of bleeding. About 501 participants will receive the balloon treatment and then take blood thinners for either the standard duration or just 7 …

This large trial tests two types of intravenous fluids given during heart surgery: hydroxyethyl starch (HES) and balanced crystalloids. The goal is to see which fluid leads to fewer serious kidney problems, such as kidney failure or death. About 1,292 adults having heart surgery …

This study tests whether a personalized blood-thinner plan can reduce bleeding in people with coronary artery disease who have received a heart stent. About 3,944 participants will either get the usual dual antiplatelet therapy (two blood thinners) or a shorter course followed by…

This study is testing a long version of the Ultimaster Nagomi stent in people with long blockages in their heart arteries. About 1,039 participants will receive the stent and be followed for one year to see if it works well and stays safe. The goal is to see if one long stent can…

This study tests whether using artificial intelligence (AI) to analyze ultrasound images during heart stent placement can reduce future heart problems. About 3,000 adults with coronary artery disease will receive a stent guided by AI-enhanced intravascular ultrasound. Researchers…

This pilot study is testing whether the anti-inflammatory drug colchicine can lower inflammation and reduce the risk of atrial fibrillation (an irregular heartbeat) after coronary artery bypass surgery. 24 adults scheduled for bypass surgery will be randomly assigned to receive e…

This study compares two methods of guiding stent placement in the left main coronary artery: standard angiography versus fractional flow reserve (FFR), which measures blood pressure across the blockage. About 960 adults with significant left main artery disease will be randomly a…

This study is a registry that follows about 960 people with coronary artery disease who are treated with a special balloon coated with a drug called sirolimus. The balloon is used to open blocked heart arteries. Researchers will track heart-related events like death, heart attack…

This study follows 840 people with a completely blocked coronary artery (chronic total occlusion) for at least 10 years. Half received a drug-eluting stent, and half got optimal medical therapy alone. Researchers will compare rates of death, heart attack, stroke, and repeat proce…

This study tests whether canakinumab, an anti-inflammatory drug, can reduce blood vessel inflammation in people with coronary artery disease. Some participants have a genetic change called TET2 clonal hematopoiesis, which may increase inflammation. 120 adults will receive either …

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study tests a new type of stent (a small mesh tube) for people with heart disease who also take blood thinners. These patients have a high risk of bleeding when they also need anti-clotting drugs after stent placement. The new stent is designed to allow a shorter course of a…

This study tests two ways to treat hardened calcium deposits in heart arteries. After using sound waves to break up the calcium, doctors will either place a drug-coated balloon or a drug-coated stent. The trial will follow 128 patients for 9 months to see which approach keeps art…

This study compares a new temporary heart pump called the Supira System to the existing Impella pump in 358 patients undergoing high-risk coronary stenting. The goal is to see if Supira is as safe and effective at supporting the heart during the procedure. Participants are random…

This study tests whether adding evolocumab, a cholesterol-lowering drug, to standard care can slow or stop plaque buildup in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack or unstable angina will receive either evolocumab plus sta…

This study tests a new stent (Orsiro Mission) that slowly releases a drug to keep heart arteries open. It is for people with long blockages (over 36 mm) in their heart arteries. About 150 participants will be followed for up to 5 years to see if the stent is safe and effective at…

This study compares two ways to treat long, diffuse blockages in heart arteries. One method uses a temporary scaffold and drug-coated balloons that leave no permanent metal behind. The other uses standard metal stents. Researchers will check how well blood flow improves right aft…

This study compares two treatments for narrowed small heart arteries: paclitaxel-coated balloons versus drug-eluting stents. About 1,380 people with stable or unstable chest pain will be randomly assigned to one of two balloon types or a standard stent. The goal is to see if ball…

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This study tests a smartphone program called HeartSteps to help people with heart disease stay physically active after cardiac rehab. Sixty adults will wear a Fitbit and use the app for 3 months to see if it boosts their weekly exercise minutes. The goal is to learn how to best s…

This study looks at whether it is safer to stop or continue taking direct oral anticoagulants (blood thinners) during planned heart procedures like angiography or stent placement. About 1,270 adults with atrial fibrillation and coronary artery disease will be randomly assigned to…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study tests whether a thinner tube (6-French Glidesheath Slender) can make heart procedures safer for people with small wrist arteries. About 594 adults with coronary artery disease will be randomly assigned to get the standard tube or the thinner one through a wrist access …

This first-in-human study tests a new device called Pulse IVL that uses sound waves to break up calcium buildup in heart arteries. Up to 15 people with coronary artery disease will receive the treatment before getting a stent. The goal is to see if the device is safe and helps op…

This study tests a new type of heart stent that dissolves over time, unlike permanent metal stents. The trial will enroll 117 people with stable coronary artery disease to see if the new stent, placed with special imaging guidance, works safely and effectively. The goal is to red…

This study looks for the best type and dose of blood thinner (P2Y12 inhibitor) for people who have had a heart stent placed. After an initial period on two blood thinners, patients switch to one. The goal is to find a dose that keeps blood clotting at a safe level—not too high (w…

This study compares two ways to treat narrowed heart arteries: a drug-coated balloon (DCB) and a drug-eluting stent (DES). Researchers will measure how much the artery narrows again over time using ultrasound. About 256 adults with significant blockages will take part to see whic…

This study compares two strategies to reduce bleeding risk in people who take two blood thinners after having a stent placed in their heart. The goal is to see if lowering the dose of one drug works as well as switching to a different drug. About 78 adults who have had a stent wi…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and i…

This study looks at whether a traditional Chinese herbal prescription called Fuzheng Yangxin can help people recover more quickly after coronary artery bypass grafting. Researchers will follow 300 patients with a specific post-surgery syndrome (Qi-Yin deficiency) to see if the he…

This study tests an inhaled medicine called Aroxxen to see if it can reduce heart damage during and after a common procedure to open blocked heart arteries (stent placement). About 180 adults with coronary artery disease will receive either Aroxxen or standard care. Researchers w…

This pilot study tests whether canagliflozin, a diabetes medication, can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. Researchers will compare the drug to a placebo over 6 months in 16 participants. The main goal is to mea…

This study tests if a special device called orbital atherectomy can better prepare hardened (calcified) heart artery blockages for stenting compared to standard balloon treatment. About 200 adults with severe blockages will be randomly assigned to one of two groups. The goal is t…

This study is testing absorbable scaffolds—temporary tubes that support blocked heart arteries and then dissolve over time—in over 1,100 people with coronary artery disease. Researchers are tracking heart-related deaths, heart attacks, and the need for repeat procedures to see ho…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with severe coronary artery disease and a weak heart pump. The goal is to see which approach better prevents death, stroke, heart attacks, or repeat procedures over 5 years. Par…

This study tests a special balloon coated with a drug (paclitaxel) to open blocked heart arteries. About 1,200 adults with coronary artery disease will receive either the Prevail balloon or another similar balloon. The goal is to see if the Prevail balloon is safe and works well …

This study tests two strategies for treating people with high-risk coronary artery disease. One strategy uses detailed imaging of plaque inside the arteries to decide which blockages need a stent or bypass. The other uses a standard blood flow test. About 1,944 participants will …

This registry is tracking 10,000 patients with coronary artery disease who receive the Supraflex sirolimus-eluting stent during routine care. The goal is to see how well the stent works in everyday practice, measuring outcomes like heart-related death, heart attacks, and the need…

This study tests whether colchicine, an inexpensive anti-inflammatory drug used for gout, can prevent heart attacks, strokes, and death in heart disease patients undergoing major surgery. Researchers will give the drug to 700 veterans before and after their operation. The goal is…

This trial tests an implantable device called the Shockwave Reducer for people with severe, persistent chest pain (refractory angina) who cannot have standard treatments like stents or bypass surgery. About 380 participants will either receive the device or a sham procedure. The …

This study monitors the safety and performance of a medical device called Sequent Please Neo, used to treat blocked heart arteries. About 2,028 people receiving the device as part of their routine care will be followed. Researchers will track major heart problems like heart attac…

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This trial tests whether using two or more arterial grafts during heart bypass surgery is better than using just one. About 4,300 patients will be randomly assigned to receive either a single arterial graft or multiple arterial grafts. The goal is to see if multiple grafts reduce…

This study tests a new surgical method for heart bypass surgery that avoids touching the aorta, aiming to reduce brain complications like silent strokes. About 380 adults with coronary artery disease will be randomly assigned to either the new no-touch technique or the standard m…

This study is testing whether giving the blood thinner cangrelor through a vein during minimally invasive heart bypass surgery is safe and practical. The goal is to prevent dangerous blood clots while the patient is on the operating table. Researchers will compare 30 patients rec…

This study tests whether using a blood pressure cuff to create brief periods of reduced blood flow (remote ischemic conditioning) combined with daily mindfulness meditation can lower the risk of heart attacks, heart failure, and chest pain in people with coronary artery disease w…

This study is testing whether using multiple arteries during coronary bypass surgery improves outcomes for women compared to using just one artery. About 2,300 women will be randomly assigned to receive either a single arterial graft or multiple arterial grafts. The goal is to se…

This study compares a newer, minimally invasive heart-lung machine (MiECC) to the standard machine used during heart surgery. Researchers want to see if the newer machine reduces serious problems like heart attack, stroke, or kidney injury. About 1,300 adults having elective hear…

This study aims to see if using tiny cameras inside the heart's arteries during stent placement leads to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for severe blockages will be included. The goal is to …

This study is testing whether a 12-week supervised exercise program can improve artery health and reduce inflammation in people with coronary artery disease. Fifty patients aged 40-70 will do aerobic, resistance, and flexibility exercises three times a week. Researchers will meas…

This study tests if using a single device (orbital atherectomy) to sand away calcium in heart arteries works as well as letting doctors choose from several methods based on each patient's calcium type. About 310 adults with severely calcified arteries will be randomly assigned to…

This study tests whether adding a Chinese herbal medicine called Yiyang Huoluo Decoction to standard heart medications can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. About 30 participants aged 50-75 will be randomly a…

This study tests whether ziltivekimab, a monthly injection that reduces inflammation, can improve artery health in people who have recently had a heart attack. About 332 participants will receive either the drug or a placebo, alongside standard care. Researchers will use special …

This study looks at two ways to treat blocked large heart arteries (≥3.5 mm) in people with coronary artery disease. One method uses a drug-coated balloon, the other a drug-releasing stent. The goal is to see which helps the artery relax and function better 8 months after treatme…

This study compares two blood thinner combinations in adults over 65 who have had a heart attack or unstable angina and received a stent. One group gets indobufen plus ticagrelor, the other gets aspirin plus ticagrelor. The goal is to see which combo better prevents heart-related…

This study looks at two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed and are on blood thinners. One approach is to switch from a stronger blood thinner to a milder one while keeping aspirin. The other is to stop aspirin and stay…

This registry is following 10,000 people who receive the BioFreedom Ultra stent, a device coated with the drug biolimus A9 to keep heart arteries open. The goal is to see how well the stent works in real-world patients, not just in controlled trials. Researchers will track proble…

This study tests whether a genetic score (ABCD-GENE) can help doctors choose the right blood thinner for patients after a heart stent. Currently, patients take two blood thinners for months. The score would guide whether to switch to a milder drug or drop one of the two. The tria…

This study tests whether a remote monitoring program can help people with coronary artery disease recover better after a heart procedure called PCI. About 200 participants will either get standard care or use a smartphone app with text follow-up and health coaching. The goal is t…

This study tests a new medicine called YN001 in people with coronary atherosclerosis (hardening of the arteries in the heart). The goal is to see if YN001 can reduce plaque buildup in the arteries when added to standard care. About 24 adults in Australia with at least one blocked…

This study follows 100 people with coronary artery disease who have already been treated with the Essential Pro device. Researchers want to confirm the device is safe and works as intended, meeting new European safety rules. The main goal is to see if the device prevents serious …

This study compares a new dissolvable heart stent (Firesorb BRS) to a standard metal stent in 2000 people with coronary artery disease. The dissolvable stent is designed to support the artery temporarily and then disappear, potentially avoiding long-term risks of permanent stents…

This study tests whether a stronger blood thinner (prasugrel) combined with aspirin works better than the standard combo (clopidogrel plus aspirin) in heart disease patients undergoing complex artery stenting. About 3,500 adults will be enrolled to see if the stronger combo reduc…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard treatment can prevent heart attacks, strokes, and death in people with high-risk coronary plaques seen on CT scans. About 3,600 adults with at least one severely narrowed or high-ri…

This study compares two blood thinners, prasugrel and ticagrelor, when used alone after stopping aspirin in people with coronary artery disease who have had a stent placed. About 48 participants will take one of the two drugs for three weeks to see which one better prevents blood…

This study compares two blood thinners—low-dose ticagrelor and standard clopidogrel—in 50 stable heart disease patients getting a stent. The goal is to see which drug better prevents blood clots around the time of the procedure. Participants take the assigned drug plus aspirin fo…

This study looks at two ways to treat people with chronic coronary artery disease (narrowed heart arteries). One group gets a special CT scan to find blocked arteries and then receives procedures like stents or bypass surgery. The other group gets only medications and lifestyle a…

This study looks at whether using a temporary mechanical heart pump during a high-risk heart procedure (PCI) can improve safety and outcomes. About 98 adults with weak hearts and complex blockages will be randomly assigned to receive the pump or standard care. The goal is to see …

This study compares two ways to open completely blocked heart arteries (chronic total occlusion): a drug-coated balloon versus a drug-eluting stent. About 200 adults with coronary artery disease will be randomly assigned to one treatment. The goal is to see which approach keeps t…

This study looks at 600 people who had a major heart attack and have other narrowings in their heart arteries that are not severe but look unstable. Half will get a stent plus medication, and half will get medication alone. The goal is to see if stenting these unstable plaques re…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This phase 2 trial tests whether meplazumab, an antibody given by IV, can reduce inflammation and fatty buildup in the arteries of people with coronary artery disease. The study involves 18 participants and will compare three different doses to a placebo. It is an early, explorat…

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study tests new plastic tubes (cannulas) used to connect patients to a heart-lung machine during heart surgery. The trial has two parts: first, a small safety check, then a larger comparison with existing tubes. About 80 adults having planned heart surgery will take part to …

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

This study tests whether a new pressure microcatheter works as well as the standard pressure wire for guiding stent placement in people with coronary artery disease. About 2,500 participants will be randomly assigned to one of the two devices during their procedure. The main goal…

This study compares a new shockwave technique to standard balloon or cutting methods for preparing severely calcified heart arteries before placing a stent. About 666 adults with coronary artery disease will take part. The goal is to see if shockwave reduces major heart and brain…

This study tests two methods to fix a common problem: a heart stent that hasn't opened fully (underexpansion). One method uses a balloon to push the stent open, the other uses shock waves (lithotripsy) to crack the blockage. About 80 people with narrowed stents will be randomly a…

This study is tracking 50,000 people with coronary artery disease who receive drug-eluting stents during a routine procedure to open blocked heart arteries. Researchers want to see how well these stents prevent major heart problems like death, heart attack, or the need for anothe…

This study looks at using a special balloon coated with medicine to open completely blocked heart arteries. About 30 people with chest pain or other symptoms will get this treatment. Doctors will use ultrasound and pressure measurements to check how well the artery opens and stay…

This study compares a new type of heart stent (XIENCE Skypoint) with other drug-coated stents in 2000 people with coronary artery disease. The goal is to see which stent is more effective and safer in real-world use. Participants will be followed for at least one year to track ou…

This study is testing whether taking clopidogrel (a blood thinner) every day for at least 5 years can prevent heart attacks, strokes, and death in people who have early signs of coronary artery disease on scans but no symptoms. About 11,000 adults aged 40 and older will be assign…

This study is tracking 1,500 people with coronary artery disease who are treated with a drug-eluting balloon during angioplasty. The balloon releases a medicine (paclitaxel) to help keep the artery open. Researchers are checking how well it works and if it is safe over the long t…

This study is tracking 2,000 people with coronary artery disease who receive either a Synergy XD or Synergy Megatron stent during a routine procedure to open blocked heart arteries. Researchers want to see how these stents perform in everyday medical practice compared to other dr…

This study tests whether a device called Bioboosti, which delivers pulsed electromagnetic fields, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow during stress and track symptoms like chest pain and exercise capacity…

This study tests whether using a detailed imaging tool called optical coherence tomography (OCT) during heart stent placement can allow patients to stop taking blood thinners sooner. Patients with stable angina who receive a stent typically take two blood thinners for 6 to 12 mon…

This study is testing whether drug-coated balloons work as well as drug-eluting stents for people with blocked heart arteries. About 321 participants will be randomly assigned to one of three treatments. The main goal is to see how well blood flows through the treated arteries af…

This study compares two types of drug-coated balloons (Selution sirolimus vs. SeQuent Please Neo paclitaxel) to treat narrowed coronary arteries in medium-small vessels. About 140 adults with stable angina or stabilized acute coronary syndrome will be enrolled. The main goal is t…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 people with pre-diabetes and coronary artery disease. The goal is to see which drug best slows or reverses the buildup of plaque in heart arteries over 24 month…

This study compares two anesthetics—desflurane gas and propofol—during coronary artery bypass surgery. Researchers want to see if desflurane helps prevent major heart problems like heart attack or heart failure within 30 days after surgery. About 3,560 adults having planned bypas…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach leads …

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This registry is tracking over 1,100 people with coronary artery disease who receive resorbable magnesium scaffolds—stents that slowly dissolve over time. The goal is to see how well these devices work in everyday medical practice, focusing on safety and whether they keep arterie…

This study tests whether adding berberine, a natural compound, can improve blood thinning in heart patients who already take aspirin and clopidogrel after a stent procedure. About 64 adults will receive either standard treatment or berberine at increasing doses for 12 weeks. The …

This study tests whether a comprehensive treatment plan can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease tied to inflammation. Researchers will compare each participant's outcomes before and after treatment. The study en…

This study looks at whether SGLT2 inhibitors (drugs like empagliflozin and dapagliflozin, typically used for diabetes) can prevent acute kidney injury caused by contrast dye used in heart X-rays and stent procedures. Researchers will review records of 4,000 patients who had these…

This study tests a new balloon coated with sirolimus (Virtue SAB) against an existing balloon coated with paclitaxel (AGENT DCB) for treating in-stent restenosis — when a previously placed stent in a heart artery becomes blocked again. About 740 people with one re-narrowed stent …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This study compares two techniques for treating severely hardened heart arteries: using a special drill (rotational atherectomy) plus shockwave therapy versus shockwave therapy alone. About 120 adults with coronary artery disease will be randomly assigned to one of the two approa…

This study tests whether a smartphone app that guides patients through a rapid recovery program (ERAS) can reduce time in the hospital after heart bypass surgery. About 480 adults in Brazil will use the app, which starts before surgery and continues for 30 days after discharge. T…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 600 minority patients with coronary artery disease. The goal is to see which approach leads to better survival and quality of life. Participants will be followed over time to track outcome…

This study enrolls 600 women with blocked heart arteries to compare two common procedures: bypass surgery (CABG) and stenting (PCI). The goal is to see which one leads to better survival and quality of life. Participants will be followed over time to measure outcomes.

This study tests a special balloon coated with medicine to treat narrowed small arteries in the heart. About 960 adults with coronary artery disease will receive either this balloon or standard treatment. The goal is to see if the balloon safely opens the artery and reduces the n…

This study is tracking 2,000 heart disease patients who receive the VIVO ISAR stent, a drug-coated device that releases medication to keep arteries open. Participants will take blood thinners for three months or less after the procedure. Researchers are monitoring for heart attac…

This study tests whether a risk-score algorithm can safely personalize how long patients take dual antiplatelet therapy (two blood thinners) after getting a heart stent. About 2,788 participants will be assigned to either algorithm-guided or standard treatment duration. The goal …

This study tests a new, less invasive way to perform coronary artery bypass grafting (CABG) that avoids touching the aorta. The new method uses a small incision in the left chest, while the standard approach opens the chest fully. Researchers will compare how well the bypass graf…

This study compares two approaches to stabilize fatty plaque in heart arteries: a moderate-dose statin plus ezetimibe versus a high-dose statin alone. Over 400 adults with coronary artery disease will be followed for a year, using advanced ultrasound to measure plaque changes. Th…

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This trial tests a special balloon coated with sirolimus (a drug) to treat small arteries in the heart, compared to standard drug-eluting stents. About 1605 people with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see if the ballo…

This study tests a temporary heart pump called iVAC 2L in 100 patients undergoing high-risk angioplasty. The pump helps stabilize blood flow during the procedure. Researchers will track deaths, heart attacks, strokes, and other complications for up to a year to see if the device …

This study tests whether the anti-inflammatory drug colchicine, combined with a special surgical technique, can prevent atrial fibrillation (a type of irregular heartbeat) after coronary artery bypass surgery. Researchers will compare 70 patients receiving colchicine plus the new…

This study is testing whether a thin wire that measures blood flow in heart arteries can help doctors decide which blockages truly need a stent. About 107 people with severe-looking blockages will have the wire test before and after stent placement. The goal is to see if some blo…

This study compares two types of CT scans—PET/CT and ultra-high-resolution CT—to see which one better detects early signs of coronary artery disease in people with symptoms like chest pain. Researchers will measure the amount of plaque in the arteries and check how accurately eac…

This study tests whether a new software-based method called Angio-IMR can diagnose coronary microvascular disease (blockages in tiny heart arteries) as accurately as the current standard test that uses a pressure wire inside the artery. About 192 adults with stable chest pain or …

This study looks at whether a special CT scan (FFR CT) can accurately measure blood flow in the heart's arteries compared to the standard invasive test. Researchers will review data from 500 patients with suspected coronary artery disease. If FFR CT proves accurate, it could redu…

This study tests a new computer program that helps doctors diagnose blocked heart arteries more accurately using CT scans. The software combines several checks into one step, which may reduce the need for invasive procedures like heart catheterization. Researchers will look at pa…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study is testing a special vest called HALD that records heart and lung sounds. Researchers want to see if the recordings are as accurate as what a doctor hears with a stethoscope. About 200 adults with or without heart or lung conditions will wear the vest during a clinic v…

This study tests a new technology called IVUS-FFR that uses ultrasound images from inside heart arteries to quickly check if a blockage is serious enough to need a stent. Unlike the current standard test, it doesn't require an extra pressure wire or medication that can cause disc…

This study is testing a new type of MRI, called hyperpolarized 13C MRI, to see if it can better identify which patients with heart disease will benefit from bypass surgery. The technique measures how the heart produces energy by tracking two simple molecules. Researchers will com…

This study tests whether artificial intelligence can detect early signs of coronary artery disease from standard chest CT scans that don't use contrast dye. Researchers will analyze scans from about 1,600 adults to see if the AI can identify dangerous plaque and blockages. If suc…

This phase 3 trial is testing whether a special PET scan using radioactive water ([15-O]-H2O) can accurately detect coronary artery disease. About 215 adults with suspected heart disease will receive the injection at rest and during stress, then compare results to standard tests.…

This study tests a new imaging method called µQFR to see how well it can detect blocked blood flow in small side branches after a heart stent is placed. About 290 adults with coronary artery disease will be enrolled. The goal is to see if this non-invasive approach can replace mo…

This study tests a new imaging tool called 3DStent that creates a 3D picture of stents placed in heart arteries. The goal is to see if it can detect when a stent is not fully expanded, which can cause problems. About 200 patients getting a stent will have both the 3DStent scan an…

This study compares two non-invasive tests for coronary heart disease: a CT scan of the heart arteries versus a stress ultrasound that also checks the neck arteries. The goal is to see which test better detects blockages and prevents heart attacks or other problems. 2,000 adults …

This study compares two ways to check heart arteries after a CT scan shows non-severe blockages: an invasive angiogram (a tube in the artery) versus standard non-invasive tests (like stress tests). About 2,000 people with chest pain or related symptoms will be randomly assigned t…

This study tests whether artificial intelligence can accurately detect coronary artery disease from ultrasound videos. Researchers will enroll 1500 people with suspected heart disease who are already scheduled for a coronary angiogram. The goal is to develop a faster, non-invasiv…

This study tests a new CT scan that works without an ECG to quickly check for heart disease in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive test to see if the new method is accurate. If successful, it could reduce…

This study tests whether giving insulin or dexmedetomidine as a nasal spray before surgery can prevent early confusion and memory problems after coronary artery bypass grafting. The trial will enroll 150 adults aged 60 and older. Participants will receive one of the two nasal spr…

This early-phase study tests whether placing amiodarone directly into the sac around the heart during open-chest surgery can prevent a common and serious irregular heartbeat called atrial fibrillation. About 63 adults aged 20-85 having bypass or valve surgery will receive this tr…

This study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …

This study tests whether using a lung water monitor to tailor fluid intake can prevent acute kidney injury in elderly patients with kidney disease who are undergoing coronary angiography. 320 participants will receive hydration rates adjusted based on their lung water levels. The…

This study tests whether an artificial intelligence program can analyze chest CT scans to find calcium buildup in heart arteries—a sign of hidden heart disease. Doctors will receive this information and may start or increase cholesterol-lowering medications to prevent future hear…

This study looks at whether a tailored prevention plan can stop coronary artery disease (CAD) in people who had cancer treatment more than 5 years ago. About 748 survivors aged 40-70 will get heart risk checks and, if needed, a CT scan to guide prevention. The goal is to catch an…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury, a common complication. 242 adults scheduled for elective heart surgery will receive either the supplements or a placebo. The goal is to see if these mitochondrial…

This study compares two breathing techniques—segmental breathing and active cycle breathing—against standard care for people recovering from open heart surgery. Researchers want to see which method best improves oxygen levels, breathing rate, and shortness of breath. The trial wi…

This study tests whether giving a set of nerve blocks (injections of numbing medicine) right after anesthesia but before surgery can reduce pain and the need for opioid painkillers after coronary artery bypass grafting. 56 adults scheduled for elective bypass surgery will be rand…

This study compares two types of nerve blocks (ESPB and SPSIPB) to see which provides better pain relief after coronary artery bypass surgery. About 64 adults aged 45-85 will receive one of the blocks before surgery, and their pain levels, opioid use, and recovery speed will be t…

This study looks at whether singing—alone or in a group—can improve heart health in older adults with coronary artery disease. Researchers will test if people stick with the program and if it's practical to run a larger trial. The study involves 32 participants who will sing thre…

This study looks at whether placing stents in blocked heart arteries can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either…

This study tests a gentle breathing method called thoraco-abdominal rebalance (TAR) in 26 adults who recently had heart bypass surgery. The goal is to see if TAR improves diaphragm movement and reduces breathing discomfort compared to standard physical therapy. Participants will …

This study tests whether watching a short educational video before a planned heart procedure (called PCI) can help lower anxiety. About 144 adults will take part, with some watching the video and others receiving usual care. Anxiety levels are measured before and after using a st…

This study tests whether giving morphine during coronary artery bypass surgery can improve pain control and reduce side effects like nausea after the operation. Sixty adults scheduled for elective heart surgery will be randomly assigned to receive either morphine or no additional…

This study tests whether giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better than a placebo. About 116 adults having planned heart surgery will take part. The goal is to see if this approach reduces pain and improves overa…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and opioid use after minimally invasive heart bypass surgery. Sixty adults undergoing this surgery will be randomly assigned to receive either the nerv…

This study will observe 60 adults having heart bypass surgery to see if a higher dose of the anesthetic propofol reduces nausea and vomiting after the operation. Researchers will compare patients who get high-dose propofol to those who get a low dose. Participants will be checked…

This study tests whether applying shockwaves to leg wounds after vein harvesting can reduce healing problems in people undergoing coronary artery bypass surgery. About 120 participants will receive either real shockwave treatment or a sham (fake) treatment. The goal is to see if …

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This study tests two improvements for heart catheterization done through a small artery in the wrist. First, it checks if a special patch can stop bleeding faster. Second, it sees if using ultrasound to guide the needle makes the procedure more successful. About 480 adults needin…

This study is creating a large database of information from 10,000 adults undergoing heart surgery. Researchers will collect detailed data before, during, and after surgery to identify factors that affect recovery and complications. The goal is to improve risk prediction, persona…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This study looks at whether a special imaging technique called Quantitative Flow Reserve (QFR) can help predict how well a blood vessel graft will work after coronary artery bypass surgery. Researchers will follow 110 patients for one year after surgery to check if the grafts sta…

This study looks at whether a special CT scan (CT-FFR) can help doctors predict heart attacks and other serious events in people with chronic coronary syndrome. About 3,000 participants in China will be followed for up to 5 years. The goal is to see if abnormal CT-FFR results are…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This registry is following 5,000 adults with coronary artery disease who received a drug-coated balloon during a procedure to open blocked heart arteries. Researchers are tracking how often the treated artery fails, heart attacks, repeat procedures, and bleeding over the long ter…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study looks for micro- and nanoplastics in the blood of the heart's arteries in 120 people with chronic coronary syndrome. Participants will have a standard heart CT and an angiogram, and a small blood sample from the heart will be tested for plastic particles. The goal is t…

This study follows 200 people having beating heart bypass surgery to see how well Getinge's devices perform and if they cause any problems. The devices help stabilize the heart and improve visibility during surgery. No extra tests or visits are needed—just information from the ho…

This study aims to develop artificial intelligence tools that can analyze heart CT scans to identify dangerous plaque buildup that may lead to heart attacks. Researchers will study 4,000 people with known or suspected coronary artery disease to create and test a computer model th…

This study gives low-dose interleukin-2 to people who have had a heart attack and are scheduled for bypass surgery. Researchers want to see how the drug affects certain immune cells (regulatory T cells) inside heart tissue compared to blood. The goal is to understand whether thes…

This pilot study tests whether having patients with coronary artery disease fill out online surveys about their symptoms and quality of life, and sharing the results with their doctors, is practical and helpful. About 200 patients and their cardiologists will take part. The goal …

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This study follows 1,500 people who are scheduled for heart surgery or a less invasive valve procedure. Researchers want to learn what factors predict major heart problems later, like heart failure or stroke. No new treatment is being tested—the goal is to gather information to i…

Many people with chronic kidney disease also have heart disease, but heart procedures like angiograms and surgery can raise the risk of kidney complications. This study tests an online decision aid called 'My Heart and CKD' that helps patients and doctors weigh the benefits and r…

This observational study looks at how lowering body temperature during heart-lung bypass surgery affects two common brain monitors (BIS and PSI). Researchers will track 60 adults undergoing planned coronary bypass surgery. The goal is to see if the monitors' readings change diffe…

This study tests whether a heart ultrasound measurement called the superior vena cava collapsibility index (SVC-CI) can predict how patients will respond to fluids during coronary artery bypass surgery. Researchers will tilt the operating table (head up then head down) to mimic g…

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who are getting a new heart valve (TAVI). One method is the usual invasive X-ray test; the other uses non-invasive risk management. The goal is to see which approach leads to be…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This study is testing a drug called regadenoson in children who need a special heart MRI. The drug helps doctors see how well blood flows to the heart during a stress test. Researchers want to find the right dose and make sure it is safe for kids of different ages, from infants t…

This study looks at whether giving less fluid during heart surgery, a technique to reduce blood loss, increases the risk of kidney injury. Researchers will measure kidney injury markers in 100 adults having elective bypass surgery. The goal is to understand if this common practic…

This study uses advanced total-body PET scans to look inside vein grafts after coronary artery bypass surgery. Researchers want to understand why some grafts fail, leading to heart attacks or strokes. They will scan 70 patients—some soon after surgery and others years later—to tr…

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study looks at people who have chest pain but no major blockages in their heart arteries. Researchers will test if giving medication based on the specific type of tiny blood vessel problem (endotype) works better than standard care. About 180 participants will be followed fo…

This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their do…

This study tests a new device that collects blood samples directly from heart arteries in 300 people with coronary artery disease. Researchers will analyze these samples to find biomarkers that could help develop personalized treatments. The goal is to better understand the disea…

This study looks at tiny structures inside heart cells called mitochondria in people with heart failure and clogged arteries. Researchers will take small heart tissue samples during bypass surgery and compare them with blood tests. They want to see if damaged mitochondria are lin…

This study tests whether a new anesthesia method for heart bypass surgery is better for patients and the planet. About 116 adults having planned bypass surgery will receive either the new technique (which uses fewer drugs and a nerve block) or standard anesthesia. Researchers wil…

This study is enrolling 1,200 people with coronary artery disease who are starting cardiac rehab. Researchers will collect detailed health data, including fitness tests, activity tracker steps, and long-term heart monitoring, to train artificial intelligence models. The goal is t…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study follows 80 adults who had coronary bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare patients who get pneumonia with those who don't, using blood tests, heart and lung functio…

This study looks at whether telling people their genetic risk for coronary artery disease helps them lower cholesterol and improve heart health over one year. Researchers will enroll 500 adults aged 30-75 who are not on cholesterol medication. Half will get their genetic risk sco…

This study follows about 20,000 people with coronary artery disease who had a special test called FFR to guide their artery-opening procedure. Researchers want to see how these patients' heart health changes over 2 years. The goal is to better understand the long-term results of …

This study is observing 10,000 people with severe narrowing in the left main coronary artery, a critical heart vessel. Researchers are comparing the long-term results of three approaches: medication, stenting with drug-coated stents, and bypass surgery. The goal is to see which w…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study follows 2000 adults with suspected heart artery disease who undergo special imaging and pressure measurements during a heart catheterization. Researchers want to see which test results best predict future heart problems like heart attacks or the need for another proced…

This study will test a new, high-speed CT scanner to see if it can measure heart artery plaque stiffness and blood flow without invasive procedures. Researchers will enroll 500 adults with known or suspected coronary artery disease. The goal is to see if this new imaging method c…

This study looks at 54 adults with coronary artery disease to see which of four treadmill tests best measures how much oxygen their bodies use during exercise. Researchers want to know if the best test differs between women and men. The goal is to improve exercise testing for peo…

This study is observing ICU heart patients who have a femoral artery sheath removed after procedures like cardiac catheterization. Researchers want to find out what factors affect how long it takes for bleeding to stop and how long patients must lie flat. The goal is to create a …

This study uses magnetic resonance spectroscopy, a special MRI technique, to measure the heart's energy levels without needles or biopsies. Researchers will compare healthy volunteers, people with heart failure, and those with other heart conditions to see if low energy metabolis…

This study is looking at 200 people having planned heart bypass surgery to see if their blood sugar levels (HbA1c) before surgery can help predict if they will develop acute kidney injury afterward. Researchers will also use ultrasound to measure kidney blood flow. The goal is to…

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

This study is for adults having planned heart bypass surgery. It tests a technique where leftover blood from the heart-lung machine is returned to the patient right after surgery. The goal is to see if this reduces the need for blood transfusions in the first 24 hours. Researcher…

This study is testing whether a simple brain ultrasound, called transcranial Doppler, can predict confusion or memory loss after heart bypass surgery. Researchers will measure blood flow in the brain during surgery and check patients for delirium and cognitive changes afterward. …

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This study aims to develop a computer model that can predict how well blood flows to the heart muscle during stress, using only a standard CT scan. Currently, this requires an additional scan and a drug to simulate stress. The researchers will analyze CT scans from 400 people wit…

This study tests whether doing several heart scans (blood flow, ultrasound, and CT) all in one day is faster and cheaper than the usual step-by-step approach for people with possible coronary artery disease. About 500 patients from Swedish primary care centers will be followed fo…

This study asks 600 people—heart disease patients and healthcare providers—to rate how serious different complications are, like heart attack or stroke, compared to death. The goal is to better understand if patients and doctors value these events differently. The results could h…

This study looks at what heart disease patients and their doctors prefer when choosing between two treatments: a permanent metal stent or a drug-coated balloon that dissolves over time. Researchers want to understand how much extra risk people are willing to accept to avoid havin…

This study is observing 165 adults with coronary artery disease who are getting a drug-coated balloon procedure. Researchers will use CT scans before and after the procedure to measure changes in blood flow and plaque buildup. The goal is to learn how the balloon affects the arte…

This study is testing a new way to predict if people with stable coronary artery disease will have a heart attack or heart injury during a planned stent procedure. Researchers will use a genetic score (ABCD-GENE) to sort 500 participants into high- or low-risk groups. The goal is…

This study will enroll 250 people with stable coronary artery disease to see how well a CT scan measures plaque buildup in heart arteries compared to an invasive ultrasound. Participants will undergo both tests as part of their standard care. The goal is to improve non-invasive d…

This study looks at 1,300 people with coronary artery disease who have a high risk of bleeding after getting a heart stent. Researchers will use artificial intelligence to analyze which blood-thinning drugs and treatment lengths work best to prevent serious bleeding and heart att…

This study looks at four simple physical tests—like timed walking and standing up from a chair—to see which one best measures how well people recover after coronary artery bypass surgery. About 150 adults aged 30-50 will be tested on the third and fifth day after surgery. The goa…

This study follows 4000 people with coronary artery disease who have had special imaging of their heart arteries. Researchers will track them for 5 years to see how well the images predict serious events like heart attacks or the need for repeat procedures. The goal is to improve…

This study follows 25,000 people with multivessel coronary artery disease to see how different treatments—medication, surgery, or stents—affect long-term health. Researchers will track serious events like heart attacks, strokes, and death. The goal is to learn which approach work…

This study compares two methods for opening completely blocked heart arteries: antegrade dissection and re-entry (ADR) versus a retrograde approach. Researchers will measure procedure time, success rates, complications, and even doctor stress levels. 74 participants with difficul…

This study looks at whether a follow-up CT scan of the heart's arteries (coronary CT angiography) one year after stent placement can reduce major heart problems like heart attacks or death compared to usual care. It will enroll 3,500 high-risk patients who have had stents placed …

This study looks at how calcium deposits in artery walls affect the healing of a stent (a small mesh tube) placed to open blocked arteries. Researchers will use a special camera to compare stent healing over calcium spots versus healthy tissue in 40 patients with coronary artery …

This study looks at 1000 people with heart artery disease who already need a special camera (OCT) inside their arteries during a routine procedure. Researchers will use those detailed images and artificial intelligence to find patterns that might predict future heart problems, li…

This study looks at 570 people with chronic coronary syndrome (chest pain or shortness of breath due to narrowed heart arteries). Participants with abnormal blood flow on a PET scan will be randomly assigned to either immediate heart catheterization or a 3-month delay, while both…

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in aci…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to learn more about heart disease that is linked to inflammation but does not progress quickly. Researchers will follow 120 adults with this condition to track their treatments and health outcomes, such as heart attacks or the need for procedures. The goal is to b…

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…

This study looks at different types of plaque in the arteries of people with coronary artery disease. Researchers will use special imaging to see the plaque and analyze blood cells at a detailed level. The goal is to understand how plaque features relate to immune responses and f…

This pilot study is testing whether wearable devices like smartwatches, blood pressure monitors, and smart scales can help patients recover after a stay in the intensive care unit (ICU). Many ICU survivors face physical and mental challenges, known as Post-Intensive Care Syndrome…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study looks at 180 non-diabetic adults with early coronary artery disease to see if a measure called the triglyceride-glucose index is linked to how many arteries are blocked. Participants will have a standard heart imaging test (angiogram) to map their artery disease. The g…