Cuffs and calm: can a blood pressure cuff and meditation cut heart risks?

NCT ID NCT06820970

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a blood pressure cuff to create brief periods of reduced blood flow (remote ischemic conditioning) combined with daily mindfulness meditation can lower the risk of heart attacks, heart failure, and chest pain in people with coronary artery disease who did not have complete artery repair. The trial will enroll 2,000 participants across multiple centers. Participants will use a device at home and listen to guided mindfulness audio sessions twice daily.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chronic remote ischemic conditioning (device) and mindfulness therapy (behavioral)
What this could lead to
If successful, this could offer a low-cost, non-drug way to reduce heart attacks and hospitalizations in people with coronary artery disease.
What could go wrong
This is a large trial but still early-stage for this specific combination. The benefits may be modest, and adherence to daily mindfulness sessions could be challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\) Age ≥18 years old * 2\) Consistent with the diagnosis of coronary heart disease, complete revascularization was not performed (coronary angiography showed that at least one vessel with a reference diameter of 3.0mm had stenosis greater than 90%, and quantitative flow ratio (QFR) \< 0.80) * 3\) Symptoms of myocardial ischemia (resting or exertional angina; Angina allele: chest tightness, shortness of breath, etc.); Exclusion Criteria: * Age \< 18 years old * Heart failure patients with NYHA class IV, or left ventricular ejection fraction (LVEF) \< 30% * Creatinine clearance \<15 mL/min (or eGFR \< 15 mL/min/1.73m²), or requires dialysis * Myocardial diseases such as hypertrophic cardiomyopathy, dilated cardiomyopathy, etc. * Uncontrolled or recurrent arrhythmic events (e.g., ventricular fibrillation, recurrent or symptomatic sustained ventricular tachycardia, complete heart block, atrial fibrillation with rapid ventricular rates, supraventricular tachycardia refractory to drugs) * Poorly controlled hypertension (SBP \> 180 mm Hg or DBP \> 110 mm Hg) * Active liver disease or persistent ALT or AST elevation ≥ 3 times the upper limit of normal * Unexplained CK \> 5 times the upper limit of normal, or elevated CK due to known muscle disease * Planned or anticipated cardiac surgery or revascularization before randomization * History of active malignancy (surgery, radiation therapy, and/or systemic therapy within the past 3 years) * Diagnosed or suspected upper extremity vascular malformations, aneurysms, arteriovenous fistulas, or thrombosis * Hearing impairment, unable to undergo mindfulness therapy * Currently participating in another drug or device study, or within 30 days of completing another drug or device study or receiving another investigational drug * Any life-threatening comorbid conditions expected to result in death within the next year (excluding cardiovascular diseases) * Alcoholism, substance abuse history; and unwilling or unable to stop alcohol or substance abuse during the study * History of major organ transplant (e.g., lung, liver, heart, bone marrow, kidney) * Investigator's judgment of known major active and uncontrolled disease, or any medical, physical, or surgical conditions (e.g., infection, significant blood, kidney, metabolic, gastrointestinal, or endocrine dysfunction) that may interfere with participation in the clinical study * As known to the investigator, the subject is unlikely to complete follow-up for more than 1 year or is expected to be unable to comply with the study requirements or understand the study's objectives and potential risks.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Fuwai Central China Cardiovascular Hospital

    RECRUITING

    Zhengzhou, Henan, 450000, China

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