Simple nasal sprays may shield Seniors' brains after bypass

NCT ID NCT06741566

Recruiting now Prevention Sponsor: Minia University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving insulin or dexmedetomidine as a nasal spray before surgery can prevent early confusion and memory problems after coronary artery bypass grafting. The trial will enroll 150 adults aged 60 and older. Participants will receive one of the two nasal sprays or a placebo twice daily for two days before their operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intranasal insulin or intranasal dexmedetomidine
What this could lead to: If it works, this could point toward a simple, low-cost way to prevent mental decline after heart bypass surgery.
What could go wrong: This is a very early (Phase 1) trial with only 150 people, so results may not be conclusive. The treatments might not work or could cause side effects like slow heart rate or cough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST OPERATIVE COGNITIVE DYSFUNCTION

Contacts and locations

Locations

Fayoum university
RECRUITING

Al Fayyum, Egypt

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