CORONARY ARTERY DISEASE

This study tested a new support program for people with coronary artery disease (CAD) who are at high risk of being readmitted to the hospital. The program combined a smartphone app for tracking health with regular check-ins from a nurse to help patients manage medications and li…

This study tested a very small balloon catheter called Sapphire 3. Doctors used it to gently open long-term, completely blocked heart arteries before placing a stent. Researchers watched 170 patients to see if the device was safe and worked well during the procedure and for 24 ho…

This large study aimed to see if taking two blood-thinning medications (clopidogrel plus aspirin) is better than taking aspirin alone for patients with multi-vessel heart disease who have received a stent. It involved 8,250 patients across 100 centers and followed them for at lea…

This study tested whether a simple, modified method using a thick gauze pad combined with a standard pressure device works better than the usual method to prevent a blocked artery in the wrist after a heart procedure. Researchers enrolled 1,568 adults who had a coronary intervent…

This study tested whether taking a low dose of aspirin twice a day is better than once a day at preventing future heart attacks, strokes, or other serious heart problems in people with diabetes or obesity who recently had a heart attack or chest pain. Researchers enrolled over 2,…

This study compared two techniques for placing heart stents when arteries branch. Researchers wanted to know if doctors should perform extra balloon inflation through the main stent into the side branch when blood flow looks acceptable. 477 patients with coronary artery disease w…

This large international study aimed to find the safest length of time for patients to take two blood-thinning drugs after a heart attack. It compared shorter and longer treatment durations to see which better balanced the risk of future heart problems against the risk of serious…

This study observed patients who received a special balloon treatment for blocked heart arteries. The balloon slowly releases a medication to help keep arteries open after clearing blockages. Researchers followed 306 patients for one year to see how often they needed repeat proce…

This study tested whether using a patient's genetic information to choose a blood-thinning drug (like clopidogrel) leads to better outcomes after a heart stent procedure. Researchers compared a group that received treatment based on their genetics to a group that received the sta…

This study tested if a blood-thinning medication (ticagrelor) could reduce markers of future heart attack risk in people with stable coronary artery disease. Researchers used a special PET scan to identify patients who had unstable, 'high-risk' fatty plaques in their heart arteri…

This small study tested whether getting a flu shot directly reduces harmful inflammation in people with stable coronary artery disease. Researchers gave 47 participants the vaccine either right away or after a one-month delay, then measured inflammation markers in their blood. Th…

This study observed how well a new type of heart stent works in everyday patients. The Ultimaster stent is coated with a medicine and a polymer that dissolves over 3-4 months, which may reduce long-term inflammation and clotting risks compared to older stents. Researchers followe…

This study tested the safety and effectiveness of a refined heart stent called Xience Sierra in a broad, real-world group of 1,757 patients. It focused on patients with various heart conditions, including many with diabetes or prediabetes, who are at higher risk for future heart …

This study tested if a 12-week home-based video rehabilitation program works as well as traditional hospital-based rehab for people recovering from heart bypass surgery. Researchers compared 110 patients who were randomly assigned to either do exercises at home with remote monito…

This study looked back at 1,695 patients with stable multi-artery heart disease to see which treatment approach best prevents heart attacks and cardiac deaths specifically related to the treated arteries. Researchers compared outcomes for patients who had bypass surgery, stent pr…

This study tested whether a virtual cardiac rehabilitation program delivered via a mobile app could improve patients' health more than standard in-person rehab. It involved 259 adults who recently had a heart attack, stent placement, or heart surgery. Researchers compared how far…

This study aimed to find the better surgical technique for placing drug-coated stents in blocked, branching heart arteries. It involved 425 patients with chest pain from coronary artery disease. Researchers randomly assigned patients to receive either the 'crush' or 'culotte' ste…

This study tested a new way to perform a common heart artery procedure (PCI) by accessing the artery through a spot on the wrist instead of the groin. It used a specially designed thinner tube to see if this approach is safe and effective, particularly for reducing bleeding and o…

This study tested two different 12-week exercise programs for men over 45 with high blood pressure and coronary artery disease. Researchers wanted to see which type of workout—interval training or continuous training—was better at smoothing out dangerous short-term blood pressure…

This study followed 3,520 patients who received the Coroflex ISAR Neo drug-coated stent to treat blocked heart arteries. Researchers tracked patients for one year to see how well the stent kept arteries open and monitored for complications like heart attacks or bleeding. The goal…

This study tested a new type of heart stent that dissolves over time, comparing it to standard stents already in use. It involved over 1,600 patients with clogged heart arteries to see if the new stent was as safe and worked as well at keeping arteries open. Patients were followe…

This trial tested a new technique called balloon lithoplasty for treating severely hardened, calcified blockages in heart arteries. It compared this special balloon, which uses pressure waves to crack the calcium, to standard balloons used to prepare the artery before placing a s…

This study tested if diabetic patients at high risk of bleeding could safely stop taking two blood-thinning drugs (DAPT) early after getting a heart stent. Doctors used a high-resolution scan (OCT) to check if the artery had healed enough one month after the procedure. If it had,…

This study tested whether keeping patients on very gentle, low-volume breathing support during heart bypass surgery is better than stopping breathing support completely. Researchers compared 60 adults having planned heart bypass surgery to see if the gentle breathing approach red…

This study tested whether a home-based rehabilitation program delivered through a smartphone app and regular phone calls could help veterans with heart or lung disease. The goal was to see if this convenient, remote approach could improve patients' fitness, help them manage their…

This study tested whether an Ayurvedic herbal supplement (Maharishi Amrit Kalash) could improve blood vessel function better than standard vitamins C and E or a placebo. It involved 143 Black men and women aged 55+ who were at high risk for heart disease. Participants took their …

This study tested whether giving the anti-inflammatory drug colchicine to patients before and after heart bypass surgery could reduce serious complications. It involved 100 patients who had recently suffered a heart attack and needed bypass surgery. Patients received either colch…

This study looked back at medical records to see how a structured heart rehabilitation program helped people with heart disease. It involved 65 patients who completed the program. The results showed improvements in how far patients could walk, their mood, their quality of life, a…

This study tested whether an intensive combination of cholesterol, blood pressure, and aspirin medications could reduce the amount of harmful plaque in heart arteries better than standard care in women. Researchers used special heart scans to measure plaque changes in 191 women w…

This study monitored the real-world safety and performance of an already-approved heart stent in routine medical practice across China. It followed over 2,000 adult patients who received the stent for coronary artery disease, tracking their health outcomes for up to five years. T…

This large study aimed to find out if using nitrous oxide (laughing gas) as part of anesthesia is safe for patients with heart disease or risk factors during major surgery. Over 7,000 adult patients at risk for heart problems were randomly assigned to receive anesthesia either wi…

This study tested if a blood thinner called argatroban is as safe and effective as the standard heparin for patients undergoing a planned procedure to open a blocked heart artery (stent placement). It involved 140 patients with stable heart disease or a certain type of chest pain…

This study compared two approaches for placing drug-coated stents in complex heart artery branches where arteries split. Researchers tested whether routinely placing stents in both branches was better than placing one in the main branch and only treating the side branch if needed…

This study tested a new device to remove blood clots during heart attack treatment. When doctors open blocked arteries with stents, clots can break apart and travel downstream, causing additional heart damage. Researchers compared a clot-trapping device (already used for strokes)…

This study tested a medical device that uses gentle sound waves (lithotripsy) to break up hard calcium deposits inside heart arteries. The goal was to safely open these hardened arteries so a stent could be placed more effectively. It involved 145 adults with coronary artery dise…

This study observed 200 patients with complex coronary artery disease who received a specific type of drug-coated stent. The goal was to see how safe and effective this stent is over the long term in patients at high risk for heart attacks or other heart-related problems. Researc…

This study checked if the Orsiro heart stent works as well in regular medical practice as it did in earlier research. It followed 556 people with clogged heart arteries who received the stent. Researchers tracked their health for 5 years to see how safe and effective the stent re…

This small pilot study tested a new type of heart stent made of magnesium that dissolves over time. It was used in 20 patients with blockages where a heart artery splits into two branches. The main goal was to see if placing this dissolving stent in these tricky spots was safe an…

This early study tested a new temporary heart pump system designed to support patients during high-risk artery-clearing procedures. The device was used in 15 stable patients with severe coronary artery disease to see if it could be safely placed and provide adequate support durin…

This study looked at a treatment for people with a completely blocked heart artery. Doctors used a special balloon coated with medicine to reopen the blockage, without leaving a permanent metal stent behind. The registry followed 309 patients for 6 months to see if this approach …

This study followed 1,000 patients who received the Ultimaster drug-coated stent to treat blocked heart arteries. Researchers compared how well this stent worked and how safe it was compared to other similar stents already in use. The goal was to see if this newer stent design le…

This early-stage study tested a new type of imaging scan to detect coronary artery disease, which causes blocked heart arteries. Researchers enrolled 15 people, some with suspected heart disease and some healthy volunteers, to see if the new scan could accurately measure blood fl…

This study tested a new, non-invasive imaging scan to measure blood flow to the heart muscle. Researchers compared this new scan to a standard, but invasive, procedure in 36 patients with coronary artery disease. The goal was to see if the new scan could accurately measure heart …

This study tested whether artificial intelligence (AI) could predict coronary artery disease by analyzing non-contact information like facial video, body temperature, and how a person walks. It involved nearly 3,000 people who were already scheduled for standard heart tests. The …

This study tested whether detailed ultrasound images of plaque inside heart arteries could accurately diagnose a condition where the heart muscle isn't getting enough blood (functional myocardial ischemia). Researchers compared the ultrasound measurements against a standard press…

This study tested whether a computer algorithm could accurately screen for coronary artery disease using only facial photographs. It involved 100 people from the community who were already at some risk for heart disease. The goal was to see if this photo-based method could be a q…

This study compared two newer heart CT scan methods against the current best test (PET scan) for measuring blood flow to the heart muscle. Researchers enrolled 20 patients already scheduled for a standard PET scan to see if the newer CT scans could provide equally accurate inform…

This study aimed to see if a new, non-invasive heart scan (called FFRCT) could be a better first step for diagnosing blocked arteries compared to standard tests. It followed 584 patients with suspected heart disease, comparing how often each approach led to unnecessary invasive p…

This study tested whether artificial intelligence (AI) could analyze standard heart CT scans to better predict which patients with coronary artery disease are at high risk for future heart attacks or other major heart problems. Researchers applied AI to scan images from over 2,00…

This study compared two approaches for diagnosing the cause of stable chest pain. It tested whether using a special analysis of a heart CT scan (called FFRct) as the first test was more efficient than following the standard step-by-step testing guidelines. The trial involved 1,40…

This large study tested whether two simple treatments could prevent serious kidney problems in high-risk patients undergoing common imaging procedures called angiography. Researchers compared intravenous sodium bicarbonate to standard saline and an oral antioxidant (NAC) to a pla…

This study tested whether gentle electrical stimulation of a nerve in the ear could help control blood pressure spikes during heart stent procedures. Researchers enrolled 480 adults with high blood pressure who were having coronary stents placed. Participants were randomly assign…

This study tested whether playing music for patients during an angiography procedure could help reduce their anxiety and improve their vital signs like heart rate and blood pressure. 50 patients scheduled for the heart artery imaging test were randomly assigned to either listen t…

This study tested whether using targeted nerve blocks with sedation is a safer and more effective way to control pain during leg amputation surgery compared to general anesthesia. It focused on high-risk patients with conditions like diabetes, heart disease, and lung disease. The…

This study looked at whether specific nerve block injections given before surgery could better control pain after a minimally invasive heart bypass operation. Researchers reviewed the medical records of 88 adults who had this surgery, comparing those who received the blocks to th…

This study tested whether adding a second type of nerve block to a standard pain control method improves recovery after heart surgery. Researchers compared pain levels, opioid medication use, and breathing function in 62 patients who received either one or two types of nerve bloc…

This study tested whether waking patients up very quickly after heart bypass surgery helps them recover better. It compared a fast-wake-up method to standard care in 100 patients. The main goal was to see if the fast-wake-up method safely reduced the need for strong heart-support…

This study tested whether using virtual reality (VR) could help patients feel less pain and anxiety during the removal of a catheter from the groin after a heart imaging test. One hundred patients were randomly assigned to either use a VR headset during the procedure or receive s…

This study tested whether a structured exercise program, started within 24 hours after heart bypass surgery, helps patients recover better. Researchers compared 40 patients who did the special exercises to those who received standard hospital care only. They looked at whether the…

This study aimed to understand if specific gene variations are connected to the risk of developing coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 Syrian participants, including people with these conditions and healthy individuals. The…

This study followed 318 patients with chest pain for about 10 years to compare two different heart scan strategies. Researchers wanted to see whether starting with a CT scan or going straight to a more invasive angiography procedure resulted in less plaque buildup in the arteries…

This study created a registry to collect information from about 3,000 patients who received a detailed imaging scan of their heart arteries. The goal was to learn which features seen on these scans might predict future heart problems, like heart attacks or issues with stents. Pat…

This study followed 750 patients with severe heart artery blockages who were considered too high-risk for traditional bypass surgery. Researchers tracked their health for a year to compare outcomes between those who received artery-opening stent procedures and those who received …

This study aimed to understand how long it takes heart surgery trainees to become skilled at using two special tools during coronary bypass surgery. The tools help surgeons check the quality of the new blood vessel connections (grafts) during the operation. Researchers observed 8…

This study aimed to see if a specific fat in the blood, called lipoprotein(a), can predict how severe blockages are in the heart arteries of people with a common, early-stage heart valve condition. Researchers looked at 100 adults with chest pain or shortness of breath to measure…

This study looked at how fixing one clogged heart artery with a stent might change the pressure readings in a second, separate clog. Researchers measured pressure in the second clog before and after treating the first one in 160 patients. The goal is to better understand how bloc…

This study aimed to understand why many Egyptian patients with heart disease are not reaching their recommended 'bad' cholesterol (LDL-C) goals. Researchers surveyed 1000 patients to see how many were on target and to identify the main barriers preventing better treatment. The go…

This study aimed to see if measuring how the body handles fats (triglycerides) could help identify which patients with stable heart disease are at higher risk for future heart problems. Researchers followed 514 people with coronary artery disease for 18 months, tracking their tri…

This study aimed to understand how treating sleep apnea might help people who also have heart disease. Researchers tested if using a CPAP machine (a device that helps with breathing during sleep) for three months could reduce a type of body stress called oxidative stress in 28 pa…

This study aimed to understand how two different types of balloons used to open clogged heart arteries affect blood flow measurements after the procedure. Researchers observed 43 patients with stable coronary artery disease who underwent this specific type of balloon treatment. T…

This study looked at 2000 patients who had a heart attack to see how many had an inherited condition causing very high cholesterol. The goal was to understand this link better, so doctors can improve screening for people at high risk. It did not test a new treatment but gathered …

This study looked at whether the exact spot where doctors insert a needle into the wrist artery affects how often that artery tightens up during a common heart test called coronary angiography. Researchers compared two different insertion distances in 380 patients to see if one l…

This study observed 4,000 patients who received XIENCE drug-coated stents to open blocked heart arteries during routine medical care. Researchers tracked patients for about 3 days after their procedure to monitor for complications like heart attacks, additional procedures, or dea…

This study aimed to understand how replacing a narrowed aortic valve affects measurements of blockages in heart arteries. Researchers followed 116 patients with both valve disease and artery blockages, taking detailed blood flow measurements before surgery, right after, and six m…

This study looked at whether a patient's vitamin D level before heart bypass surgery is linked to how well their blood recovers afterward. Researchers followed 135 patients to see if vitamin D influences hormones that control iron and red blood cell production. The goal was to ga…

This study looked at how a natural antioxidant called quercetin and a common cholesterol medication (atorvastatin) affect hormone levels in postmenopausal women with heart disease. Researchers compared 60 women taking either quercetin, atorvastatin, or a placebo for 60 days. The …

This study aims to develop an artificial intelligence (AI) tool to better predict which patients with early signs of heart disease are at highest risk of having a heart attack or dying from heart problems. Researchers will analyze CT scans and health data from 3,000 patients to t…

This study aimed to measure how much radiation patients receive during common heart CT scans worldwide. Researchers collected data from 36 adults who needed these scans to check for heart disease. The goal was to understand current scanning practices and identify opportunities to…

This study looked back at data from over 2,300 people with known or suspected coronary artery disease. Researchers wanted to see if the results from a special stress heart MRI test could predict who would later suffer serious heart events, like a heart attack or death from heart …

This study explored whether detailed eye scans could predict resistance in the small blood vessels of the heart. Researchers examined 101 adults with moderate coronary artery narrowing, taking measurements from both their heart arteries and their eyes. They used computer learning…