CORONARY ARTERY DISEASE

This trial tests whether a structured support program can help people with coronary artery disease maintain regular exercise after completing cardiac rehabilitation. Participants receive group counseling calls, personal phone check-ins, and introductions to community exercise pro…

This study tests a new stenting technique called double kissing nano-culotte for people with complex blockages in heart arteries. The procedure uses two stents with minimal overlap to keep arteries open. Researchers will track 12 patients for heart attacks, repeat procedures, or …

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This study tests a culturally appropriate education program called Indigenous SIPin to help Native American men reduce their intake of sugary drinks like soda and juice. The program includes classes and text messages, and involves 48 men from Native American athletic communities.…

This trial tests two types of drug-coated balloon catheters to treat small, newly blocked heart arteries. About 180 adults with stable or unstable angina will be randomly assigned to receive one of the two devices during a standard angioplasty procedure. The goal is to see which …

This study looked at how well the PROMUS PREMIER stent works in everyday medical practice in China. Over 2,000 people with coronary artery disease received the stent and were followed for 12 months to track major heart problems like heart attacks or the need for another procedure…

This trial tests whether the gas xenon can reduce heart muscle damage during coronary artery bypass surgery compared to two standard anesthetics: sevoflurane and propofol. About 500 adults with coronary artery disease scheduled for elective bypass surgery will be randomly assigne…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take on…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study tested whether sending personalized text messages about lifestyle changes could improve heart health in 700 people who had a stent placed for coronary artery disease. Half received 4 texts per week for 24 weeks, while the other half got standard care. Researchers measu…

This study tests whether motivational interviewing—a supportive, goal-oriented counseling approach—can help people who have had a heart stent adopt and maintain healthier habits. Participants receive one-on-one coaching sessions and reminder texts over three months, while researc…

This study tests a newly designed device to hold arterial pressure monitoring lines in place after coronary artery bypass surgery. The goal is to see if it keeps readings more accurate and stable than standard tape, especially when patients move. Sixty adults undergoing bypass su…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study tested a new device called Firesorb, a temporary scaffold that slowly releases medicine to keep heart arteries open and then dissolves over time. Researchers compared it to a standard permanent stent in 430 people with coronary artery disease. The goal was to see if th…

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This study tested whether a breathing muscle training device could improve blood flow in the hearts of people with coronary artery disease. Forty participants used the device daily for six weeks. Researchers compared high-intensity versus low-intensity training to see if it incre…

This study looked at whether a 12-week course of glecaprevir/pibrentasivir can safely cure hepatitis C in heart transplant patients who got the virus from infected donors. Fifty adults on the transplant waitlist were enrolled, and those who received a hepatitis C-positive heart w…

This completed study looked at over 3000 people with coronary artery disease to compare two types of drug-eluting stents: everolimus-eluting (Xience/Promus) and sirolimus-eluting (Cypher). The goal was to see which one better prevents major heart problems like heart attacks or th…

This study tested two different drug-coated stents (everolimus-eluting vs. sirolimus-eluting) in 1,466 people with narrowed heart arteries. It also compared taking the blood thinner clopidogrel for 6 months versus 12 months after stenting. The goal was to see which stent and whic…

This study tested whether quercetin, a natural compound found in fruits and vegetables, can reduce inflammation and signs of cell aging in 100 people undergoing heart bypass surgery. Participants received quercetin or a placebo before and after surgery. The goal was to see if que…

This early study tested whether placing a thin layer of human amniotic membrane on the heart during bypass surgery could reduce inflammation and prevent post-operative atrial fibrillation (an irregular heartbeat). Twenty-seven patients were randomly assigned to receive either the…

This study looked at two ways to treat heart attack patients who have multiple blocked arteries. One group had all blockages fixed in a single procedure, while the other group had the main blockage fixed first and the others in a separate procedure later. The goal was to see if t…

This study tested a new device called the Wave PRO System that helps improve blood flow in people with chronic stable angina (chest pain). The device works by gently squeezing the legs to push more blood to the heart. The study included 52 adults with mild to moderate coronary ar…

This study tested a two-step procedure for people with severely hardened heart arteries. First, doctors used a special device to shave away hard plaque, then inflated a drug-coated balloon to open the artery. The goal was to see if this approach could safely improve blood flow an…

This study looked at 218 older adults (over 60) with severe calcium buildup in their heart arteries. Researchers compared a drug-coated balloon to a drug-coated stent to see which worked better. The goal was to find a way to open blocked arteries and improve blood flow without ne…

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or n…

This study looked at how different amounts of aerobic exercise affect blood flow and fitness in 115 people with heart disease. Participants joined a cardiac rehab program and were monitored for changes in skin blood flow and oxygen use during exercise. The goal is to find the mos…

This study tested whether removing the ligament of Marshall during coronary artery bypass surgery could prevent a common complication: atrial fibrillation. 220 high-risk patients were randomly assigned to get the extra procedure or standard surgery alone. The goal was to see if t…

This study tested whether taking a daily probiotic drink called Goodbelly for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if the probiotic made …

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study looked at whether lowering the use of anticholinergic drugs—common in older adults and linked to confusion and frailty—before and after heart surgery can help patients recover better. Researchers studied 120 adults having elective coronary artery bypass surgery. They m…

This study tested a device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. It involved 145 people with severe coronary artery disease. The goal was to see if the device is safe and helps stents work better.

This study tested whether adding oat bran to the diet could improve cholesterol levels and reduce inflammation in people with coronary artery disease. Thirty-two patients who recently had angioplasty took part. Half ate 28 grams of oat bran daily for two months, while the other h…

This early study tested a new device called the Supira System in 15 people with coronary artery disease undergoing high-risk angioplasty. The device temporarily helps the heart pump blood during the procedure. The goal was to see if it is safe and works as intended, not to cure t…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This trial tested a new type of stent (a small mesh tube) that slowly dissolves after being placed in a heart artery. The stent is coated with a drug to prevent the artery from narrowing again. Over 1600 patients with stable heart disease or a mild heart attack received either th…

This study tested whether applying a patient's own platelet-rich plasma (PRP) to the chest wound during heart surgery reduces infections and improves healing. 98 adults undergoing bypass surgery were randomly assigned to receive PRP or standard wound closure. Results showed that …

This study tested whether a smartphone app and regular phone calls could help people with heart or lung disease complete rehabilitation at home instead of going to a clinic. The program included exercise tracking, education, and counseling over 12 weeks. Researchers wanted to see…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested a very small balloon catheter (Sapphire 3) in 170 people with severely blocked heart arteries (chronic total occlusions). The balloon was used to open the blockage before placing a stent. The main goal was to see if the device could be safely delivered, inflated…

This study looked at a device called Coroflex ISAR Neo, a stent used to open blocked heart arteries. Researchers wanted to see if it was safe and worked well. Over 3,500 people with coronary artery disease took part. The main goal was to see how many needed a repeat procedure wit…

This study tested three doses of argatroban, a blood thinner, in 140 patients undergoing elective heart stent procedures. It compared argatroban to the standard blood thinner heparin, both given with clopidogrel and aspirin. The goal was to see how well argatroban prevents blood …

This study looked at the best way to use drug-eluting stents (tiny mesh tubes that release medication) in patients with coronary artery disease where the blockage is at a fork (bifurcation). 413 patients were randomly assigned to get stents in both branches of the fork or only in…

This study tested two ways to place stents in heart arteries that have a branch (bifurcation). 425 patients with chest pain were randomly assigned to either the 'crush' or 'culotte' technique. Researchers tracked heart-related deaths, heart attacks, stent clots, and the need for …

This study tested a special stent made of magnesium that slowly dissolves in the body. The stent releases a drug to prevent scarring and was used in 20 patients with complex blockages where arteries branch. The goal was to see if it is safe and works well for these tricky cases.

This study tested a special balloon coated with medication to reopen completely blocked heart arteries in 309 people. The balloon delivers drug to keep the artery open without leaving a permanent stent. Researchers checked if the artery stayed open and if there were any heart pro…

This study looked at how well the Ultimaster stent works compared to other stents used to open blocked heart arteries. About 1,000 adults with coronary artery disease who received the Ultimaster stent were followed to track deaths, heart attacks, and the need for repeat procedure…

This study looked at a special balloon coated with sirolimus, a drug that helps keep arteries open, to treat large blockages in the heart's blood vessels. Over 300 adults with coronary artery disease were treated and followed for one year to see if they needed another procedure t…

This study tested whether a stellate ganglion block (a nerve injection) before coronary artery bypass surgery can prevent new atrial fibrillation, a common complication. 108 patients were included. The approach aims to calm the nervous system and reduce inflammation. Results coul…

This completed study looked at 60 postmenopausal women with stable coronary artery disease. Researchers tested whether adding a daily 1000 mg quercetin supplement to standard atorvastatin treatment could affect levels of estrogen and a protein called SIRT1, which are linked to he…

This study tested a virtual cardiac rehabilitation program using a smartphone app, a fitness wristband, and a blood pressure monitor for people who recently had a heart attack, heart surgery, or a stent. The goal was to see if this home-based program could improve walking ability…

This study tested a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. It included 110 adults with stable or unstable coronary artery disease who had long blockages (at least 25 mm) in their heart arteries. The main g…

This study tested whether a device that gently stimulates a nerve in the ear (vagus nerve) can help control blood pressure during heart stent placement. 480 adults with coronary artery disease and high blood pressure were randomly assigned to receive either real or sham stimulati…

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal…

This study looked at a special drug-coated stent (Genoss DES) in 200 people with coronary artery disease who are at high risk for heart attacks. The stent slowly releases sirolimus to help keep the artery open. Researchers tracked how many patients had heart-related death, heart …

This study followed 204 people with coronary artery disease who received the Ultimaster stent, a thin mesh tube coated with a drug that slowly releases to prevent arteries from clogging again. The stent's coating dissolves over 3-4 months. Researchers tracked safety and effective…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study looked at whether people with diabetes and a high risk of bleeding can safely stop taking two blood thinners (DAPT) just one month after getting a special stent, instead of the usual six months. Doctors used a special camera (OCT) to check if the artery had healed enou…

This study tested whether a 12-week home-based telerehabilitation program works as well as traditional center-based cardiac rehab for people who had coronary artery bypass surgery. 110 stable patients, aged 30 to 75, were enrolled. The main focus was on changes in exercise capaci…

This study looks at whether a blood thinner called ticagrelor can lower heart attack risk in people with high-risk fatty plaques in their heart arteries. Researchers used a special PET scan to find these plaques in 220 patients with coronary artery disease. Participants took eith…

This study looked at whether giving patients their own blood left over in the heart-lung machine after bypass surgery could reduce the need for donor red blood cell transfusions. Sixty adults having elective coronary bypass were split into two groups: one received the leftover bl…

This early study tested whether a biologic called PEP, made from donor blood particles, is safe to infuse into heart arteries right after stent placement. Nine patients received a single dose during catheterization. The goal was to see if PEP could reduce heart damage, but the ma…

This study tested whether a special balloon that uses sound waves to break up calcium (balloon lithoplasty) works better than standard balloons for preparing severely calcified coronary arteries before placing a stent. The trial involved 200 adults with stable heart disease or no…

This study tested a nurse-led disease management program using a mobile app and telehealth for people with coronary artery disease at high risk of returning to the hospital. The program aimed to help patients manage their condition through education, medication support, and lifes…

This completed trial tested an Ayurvedic herbal supplement called Maharishi Amrit Kalash (MAK) against vitamins C+E and a placebo in 143 Black adults aged 55+ with heart disease or high risk. The goal was to see if MAK improves blood vessel function, measured by how well arteries…

This study tested a simple method to prevent wrist artery blockage after a common heart procedure. Over 1500 patients had their wrist artery pressed with a special thick gauze pad plus a standard device, or just the device alone. The goal was to see if the gauze method reduced ar…

This study looked at whether using a person's genetic information to choose their blood-thinning medication (clopidogrel or an alternative) leads to better outcomes after a heart procedure. 283 adults with chronic coronary artery disease who had a stent placed were split into two…

This study tested a stent retriever device, already used for strokes, to remove clots during heart attacks. The goal was to reduce damage to small heart blood vessels caused by clot fragments. 81 patients with severe heart attacks were enrolled to see if the device works better t…

This study tests whether a software tool called AutocathFFR can accurately measure the severity of coronary artery blockages from standard 2D angiogram images, compared to the gold-standard invasive FFR measurement. The software uses machine learning to analyze images taken durin…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This early study tests a new radioactive dye, F-18 rhodamine 6G, to see if it can produce clearer PET scans of the heart. The dye is injected and then images are taken to measure blood flow in the heart muscle. The trial includes both healthy volunteers and people with stable cor…

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. Th…

This study tested a new type of CT scanner (photon-counting detector CT) to see if it gives clearer images of heart arteries and blood flow compared to standard CT and nuclear stress tests. Researchers enrolled 276 adults with suspected coronary artery disease. The goal was to se…

This completed trial tested whether an artificial intelligence (AI) tool could help doctors decide which low-risk patients with suspected heart disease should get a safer, non-invasive CT scan instead of an invasive angiogram. The study involved 251 adults referred for non-urgent…

This study compared two contrast agents (Dotarem and Gadovist) used in cardiac MRI to see which provides clearer images of heart muscle damage. 120 adults with coronary artery disease or cardiomyopathy received one of the two dyes during their scan. Researchers rated image qualit…

This study tested whether a new, non-invasive finger sensor (Oxygen Reserve Index, or ORI) can predict breathing complications after coronary artery bypass surgery better than standard spirometry. Researchers measured ORI and spirometry in 142 adults before surgery and tracked lu…

This completed study tested whether a special ultrasound scan (IVUS) of plaque buildup in heart arteries can accurately diagnose reduced blood flow (functional myocardial ischemia). Researchers enrolled 105 adults with coronary artery disease and compared IVUS results to the stan…

This study compared two types of heart scans—CT and PET—to see if CT can measure blood flow to the heart as accurately as PET, which is the current gold standard. Researchers enrolled 20 adults with suspected coronary artery disease. Each participant received both a CT scan and a…

This early-phase study tested a new radioactive tracer called Ga-68 Galmydar for PET scans of the heart. The goal was to see if it can accurately show blood flow to the heart muscle in people with or without coronary artery disease. Fifteen adults received the tracer and underwen…

This study tested a new, non-invasive imaging method to measure blood flow in the heart muscle. It involved 36 people with coronary artery disease who already needed a heart catheterization. The goal was to see if the new scan could give the same results as the standard invasive …

This study tested whether a computer algorithm can spot signs of coronary artery disease by analyzing facial photos. Researchers enrolled 100 adults from the community who had a moderate risk of heart disease. The goal was to see how well the algorithm could identify those with b…

This study tested whether a special CT scan called FFRct can help doctors better manage stable chest pain compared to standard guidelines. About 1,400 adults with chest pain but no other major heart issues took part. The goal was to see if using FFRct as the first test reduces th…

This study tested whether artificial intelligence can predict coronary artery disease using non-contact information, such as facial images or other external data, without any needles or scans. Researchers enrolled nearly 3,000 people suspected of having heart disease and compared…

This study tested a new software program that analyzes heart angiogram images to measure blood flow blockages without needing to insert a pressure wire into the artery. Researchers reviewed the records of 100 patients who had both an angiogram and an invasive pressure measurement…

This study tested whether a computer analysis of CT scans (called FFRCT) can better guide decisions about heart artery blockages compared to usual care. About 584 people with suspected coronary artery disease took part. The goal was to see if using FFRCT reduces the number of unn…

This study tests a specially designed set of infection-prevention steps (a 'bundle') for people undergoing coronary artery bypass graft (CABG) surgery. The goal is to see if this bundle reduces surgical wound infections, both superficial and deep. The trial includes 200 participa…

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This study tested whether giving IV acetaminophen (Tylenol) every 6 hours during and after heart surgery could prevent delirium—sudden confusion—in patients aged 60 and older. Delirium is common after heart surgery and can lead to longer hospital stays and other problems. The tri…

This study tested whether making a small cut in the sac around the heart (posterior pericardiotomy) during open-heart surgery can prevent a common complication called atrial fibrillation. 210 adults having elective heart surgery in Yemen were randomly assigned to receive either t…

This large study tested whether giving sodium bicarbonate (a type of fluid) or N-acetylcysteine (a supplement) before and after angiography could prevent serious kidney problems, including death or need for dialysis. Over 5,000 high-risk patients with kidney disease took part. Th…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tested two types of nerve blocks (SAP and PECS II) to see if they could reduce pain after coronary artery bypass grafting. 243 adults received one of the blocks or standard care. Researchers measured pain scores, opioid use, and recovery times. The goal was to find a b…

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This pilot trial tests a technique called cryoanalgesia, which uses extreme cold to temporarily freeze nerves in the chest during heart surgery. The goal is to block pain signals, potentially reducing the need for opioid painkillers and improving recovery. The study enrolls adult…

This study compared two ways to control pain after minimally invasive heart bypass surgery: a newer erector spinae plane block (ESPB) versus the standard paravertebral block (PVB). 140 patients received one of the two blocks using the numbing drug ropivacaine. The goal was to see…

This study tested a safe early mobilization plan for 60 patients who had coronary artery bypass surgery. The plan included gentle activities like sitting up, deep breathing, and walking starting the day of surgery. The goal was to see if this approach could reduce dizziness, impr…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This study compares two types of nerve blocks (ESPB and SPSIPB) to manage pain after heart bypass surgery. About 60 adults aged 18-80 having planned bypass surgery will take part. The goal is to see which block reduces the need for painkillers and improves comfort after surgery.

This study tested whether regular phone calls from a nurse after coronary artery bypass surgery could help patients manage symptoms and take better care of themselves at home. 72 patients were split into two groups: one received standard care, and the other got scheduled phone co…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study looked at 50 adults having heart bypass surgery to see if one sedative (dexmedetomidine) causes less confusion after surgery than another (midazolam). The goal was to find a way to reduce postoperative delirium, a common problem after heart surgery. Researchers checked…

This study tested whether a nurse-led program, including education and an animated video, could reduce anxiety in 60 adults scheduled for coronary artery bypass graft surgery. Participants were split into two groups: one received the extra program, the other standard care. Resear…

This study looked at whether amlodipine, a blood pressure medicine, can help people with stable angina (chest pain) who already have stents but still have narrowed arteries. About 211 participants took amlodipine or no calcium-channel blocker for 9 months. The main goal was to se…

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assig…

This study tested whether avoiding morphine during heart surgery could reduce common complications like breathing problems, confusion, and gut issues. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia or a combinat…

This study looked at 60 adults having heart bypass surgery to compare two types of chest wall nerve blocks for pain control. One group got a combination of two blocks, the other got a different pair. Researchers measured pain scores and how much extra pain medicine patients neede…

This study looked at whether circuit training, with or without added arm and leg resistance exercises, could help people who had heart surgery breathe easier at night and improve their daily function. Sixty adults aged 35 to 65 who had bypass surgery 3 to 6 months earlier took pa…

This study tested whether special nerve blocks (fascial plane blocks) can improve pain control and reduce time on a breathing machine after open-heart surgery. 206 adults having heart surgery were divided into two groups: one received the nerve blocks plus standard pain care, the…

This study looked at whether using an incentive spirometer (a device that encourages deep breathing) after coronary artery bypass surgery helps improve oxygen levels and vital signs. 58 patients were randomly assigned to receive either standard care or standard care plus the brea…

This study tested whether using a vibrating device, alone or with a cold gel pack, could reduce pain and anxiety when chest tubes are removed after coronary artery bypass surgery. 93 patients were split into three groups: vibration only, vibration plus cold, or standard care. Res…

This study tested whether adding a diaphragm release technique to standard cardiac rehabilitation could improve sleep quality and lung function in 30 patients who had coronary artery bypass surgery. One group received standard rehab plus the diaphragm release, while the other rec…

This study looked at whether Clinical Pilates exercises can help people who have had coronary artery bypass grafting (CABG) overcome kinesiophobia — a fear of movement that can slow recovery. 36 patients who were stable after surgery and had kinesiophobia took part. They did 30-m…

This study looked at whether giving precise amounts of fluid during coronary artery bypass surgery can reduce the risk of postoperative cognitive dysfunction (POCD) — problems with memory, focus, and thinking that affect up to 70% of heart surgery patients. Researchers monitored …

This study tested whether two types of nerve blocks (SAP and PECS) can reduce pain and shorten the time patients need a breathing tube after heart bypass surgery. 243 adults undergoing open heart surgery received either a nerve block or standard pain medication. Researchers measu…

This study looked at whether playing music during an angiography procedure can lower patients' anxiety and keep their vital signs stable. Fifty adults with coronary artery disease were randomly assigned to either listen to music during the procedure or receive standard care. Rese…

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks could provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a chest incision received the nerve block with or without the e…

This study tested whether adding a recto-intercostal fascial plane block (RIFPB) to a standard pecto-intercostal fascial plane block (PIFPB) improves pain control after open-heart surgery. Forty adults scheduled for heart surgery received both blocks with the anesthetic bupivacai…

This study tested whether a special 'ultra-fast-track' anesthesia method helps patients recover faster after coronary artery bypass surgery. In this approach, patients wake up and have their breathing tube removed in the operating room or within the first hour, instead of later i…

This study looked at 40 men over 45 with high blood pressure and heart disease to compare two types of exercise: interval training and continuous training, both including aerobic and resistance exercises. The goal was to see which better improves heart function and blood pressure…

This study tested whether using virtual reality (VR) during the removal of a tube from the groin after a heart procedure could reduce pain and anxiety. One hundred adults were randomly assigned to either wear VR goggles showing calming scenes or receive standard care. Researchers…

This study looked at whether having a supervisor guide breathing exercises helps heart bypass patients recover lung function better than doing them alone. Thirty-eight adults who had coronary artery bypass surgery did incentive spirometry (a breathing device) twice daily for thre…

This study looked at two ways to manage pain after coronary artery bypass surgery. All 72 patients received a standard parasternal nerve block, and half also got an additional serratus anterior plane block. Researchers measured pain scores and how much pain medicine patients need…

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study tested whether elastic therapeutic taping can reduce pain after open-heart surgery (CABG). 195 patients were randomly assigned to receive real tape, placebo tape, or another supportive treatment near the surgical site. Neither patients nor researchers knew who got whic…

This study tested whether using virtual reality (VR) in the waiting room could reduce anxiety in 156 adults about to undergo a heart catheterization. Participants used VR while waiting for their procedure, and researchers measured their stress levels using heart rate monitors and…

This study looked at whether giving specific nerve blocks (PECS II, parasternal, and serratus plane blocks) before surgery can reduce pain after minimally invasive heart bypass surgery (MIDCAB). Researchers compared 88 patients who either received the blocks or standard painkille…

This study looked at whether music therapy can reduce pain and anxiety in people who had coronary artery bypass grafting (CABG). Sixty adults were enrolled, and those in the music group listened to music before and during surgery. Afterward, they reported their pain and anxiety l…

This study tested whether a nerve block called erector spinae plane block (ESPB) can improve pain control and recovery in adults undergoing open-heart surgery. Sixty-six participants received either the nerve block or standard IV opioids. Researchers measured pain scores, need fo…

This study tested whether a nerve block given before heart surgery can reduce pain and the need for opioids afterward. 76 patients received either the block or a placebo injection. Researchers measured pain scores and opioid use in the first 24 hours after surgery.

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and…

This study tested whether a structured early exercise program helps people recover better after coronary artery bypass surgery. Forty adults who had their first bypass surgery were split into two groups: one received standard hospital care plus supervised exercise starting within…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigne…

This study tested whether the sleep medication suvorexant (Belsomra) can help older adults sleep better and reduce confusion after heart surgery. One hundred patients aged 60 and older received either suvorexant or a placebo for seven nights in the ICU. Researchers measured sleep…

This study tested whether electroacupuncture (using mild electric pulses through thin needles) can protect the heart and reduce inflammation in 104 people undergoing coronary artery bypass surgery. Researchers measured heart injury markers like troponin and inflammation levels. T…

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This study follows 500 heart bypass patients for 10 years to see if taking two blood thinners (ticagrelor plus aspirin) for one year after surgery reduces the risk of heart attacks, strokes, or death compared to taking just one. Participants will be contacted by phone to report t…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study reviewed records of 65 heart disease patients who completed a structured exercise program. Researchers compared their fitness, depression levels, quality of life, and sleep quality before and after rehab. The goal was to see if the program helped improve these areas. B…

This study tracks thousands of heart-surgery patients to identify factors that may increase the risk of postoperative delirium — a state of sudden confusion. Researchers are examining whether medications like statins and beta blockers, the use of a heart-lung machine, or the leng…

This study looks at four simple physical tests—like timed walking and standing up from a chair—to see which one best measures how well people recover after coronary artery bypass surgery. About 150 adults aged 30-50 will be tested on the third and fifth day after surgery. The goa…

This study aims to develop a computer model that can predict how well blood flows to the heart muscle during stress, using only a standard CT scan. Currently, this requires an additional scan and a drug to simulate stress. The researchers will analyze CT scans from 400 people wit…

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This completed study looked at 76 people having heart bypass surgery. It tested two different ways of managing the pressure in the breathing tube during the procedure to see if it affected swelling in the airway. The goal was to find a safer pressure level to reduce complications…

This study looks at 1,700 people with heart disease to see how different treatments—surgery, stents, or medication—affect kidney function over 5 years. Researchers will track changes in kidney health and check for new or worsening kidney disease. The goal is to help doctors choos…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study follows 200 adults who have elective coronary bypass or heart valve surgery to see how their physical abilities, lung function, and muscle strength change after the operation. Researchers measure walking speed, balance, handgrip strength, and breathing tests before and…

This completed study looked at whether four easy-to-use nutrition scoring tools (GNRI, MNA-SF, PNI, and NAF) can predict serious lung complications after heart surgery in 217 patients aged 60 and older. Researchers tracked problems like pneumonia, blood clots in the lungs, and ne…

This study looked at 250 adults with stable coronary artery disease to see if feeling empowered and having a sense of purpose (called 'ikigai' in Japanese) are connected. Researchers used surveys to measure these feelings and how they relate to each other. The goal is to help nur…

This study looked at whether a quick bedside test (Hemochron Jr) gives the same results as standard lab tests for measuring blood clotting in people having planned heart bypass surgery. Twenty patients were tested before and after being placed on a heart-lung machine. The goal wa…

This study looked at damage to the protective lining of blood vessels during heart bypass surgery. Researchers measured a substance called syndecan-1 in the blood of 147 patients to see when and why this damage happens. The goal was to understand how surgery affects the body and …

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This completed study looked at 1000 people who had a coronary stent placed to see if a score based on insulin resistance could predict whether the stent would narrow again (restenosis). Researchers measured insulin resistance using routine blood tests and checked for restenosis w…

This study looked at how a sedative called dexmedetomidine affects heart function during off-pump coronary artery bypass surgery. Researchers used ultrasound to measure heart pumping ability in 36 patients with coronary artery disease. The goal was to see if this medication helps…

This pilot study tested whether drinking beet juice twice daily for two weeks could improve blood vessel function and breathing muscle strength in older adults with coronary artery disease. Eight participants were randomly assigned to receive either nitrate-rich beet juice or a p…

This study looked at 81 patients who had coronary artery bypass surgery to find out what factors affect how long they need a breathing tube afterward. Researchers checked things that happened before, during, and after surgery. The goal was to better understand what influences rec…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is…

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This completed study tested whether a telehealth program, including a heart monitor and regular phone check-ins, could reduce symptoms and improve self-care and quality of life in 160 adults who had coronary artery bypass surgery. Participants were randomly assigned to either the…

This study looked at data from 100 patients who had heart artery imaging and pressure measurements. Researchers developed a new computer algorithm to analyze ultrasound images of the arteries and estimate how much they block blood flow. The goal was to see if the algorithm could …

This completed registry followed over 17,000 Korean patients with coronary artery disease who received drug-eluting stents. Researchers compared several types of stents to see which ones work best and are safest over the long term in everyday medical practice. The goal is to prov…

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study tested a new imaging catheter (a thin tube with a camera) used during heart procedures to take pictures of the coronary arteries. 34 adults who were already scheduled for a heart catheterization or stent procedure took part. The goal was to see how easy the catheter wa…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This study looked at 70 adults having open heart surgery (aortic valve or bypass). It compared a newer, smaller heart-lung machine to the standard one. The goal was to see which method better protects the body's tissues and the brain during surgery. Results will help doctors choo…

This study looked at 60 heart surgery patients to see how two different bypass machines affect blood flow in tiny vessels under the tongue. One method was minimally invasive, the other was the standard approach. The goal was to find out which technique keeps small blood vessels w…

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This completed study in Syria examined whether certain genetic variations in the apelin system are linked to coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 participants, including healthy controls and patients with heart disease and h…

This study followed 318 people with suspected coronary artery disease for about 10 years to see whether starting with a CT scan or an invasive angiogram leads to better long-term outcomes. Participants had already completed an earlier study and agreed to additional follow-up, inc…

This study looked at two different methods used to protect the heart during coronary artery bypass surgery. Twenty patients were randomly assigned to receive either Calafiore or modified Del Nido cardioplegic solutions. Researchers measured heart muscle damage markers and amino a…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This study looked at 191 women with non-obstructive coronary artery disease (plaque that doesn't block arteries). Researchers used CT scans to measure whether intensive medical therapy (like statins and blood pressure drugs) reduced plaque more than usual care. The goal was to se…

This study looked at 55 adults having beating-heart coronary bypass surgery. Doctors compared a standard ultrasound method (TEE) with a less invasive monitor that uses the arterial line to see how well each predicted the need for extra fluids. The goal was to see if the simpler d…

This study looked at whether using very small breaths (ultra-low tidal volume) during heart bypass surgery can reduce stress on the lungs and help patients recover faster. Sixty adults having planned bypass surgery were randomly assigned to receive either this gentle breathing me…

This study looked at 485 patients who had coronary artery bypass surgery to see if a computer method called fuzzy logic could better predict who is at risk of dying. Fuzzy logic is a way to handle uncertain information, similar to how doctors think. The goal is to create a tool t…

This completed study with 50 adults undergoing coronary bypass surgery tested whether a neck ultrasound (corrected carotid flow time) and a simple leg-raising maneuver can reliably show if a patient needs more fluids. The goal was to find a non-invasive alternative to standard in…

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). About 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart at…

This study tested two different solutions used to protect the heart during coronary artery bypass surgery. Forty adults having non-emergency bypass surgery took part. Researchers measured heart enzyme levels and other recovery signs in the first two days after surgery to see whic…

This study looked at how doctors in the U.S. manage blood thinners in heart patients who need surgery. The goal was to understand the risks of bleeding and clotting with different approaches. 147 patients were observed to gather data for future research. No new treatments were te…

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This completed observational study looked at 43 patients with stable coronary artery disease who had balloon angioplasty. Researchers measured blood flow (fractional flow reserve) right after the procedure and compared it with angiographic images. They also compared two types of …

This study looked at whether continuously measuring oxygen levels in the brain during heart bypass surgery can reduce memory and thinking problems after the operation. 326 older adults (age 60+) having planned heart surgery took part. Researchers compared standard care to care gu…

This study looked at 1,695 people with stable heart disease affecting multiple arteries. Researchers compared long-term outcomes for those who had bypass surgery, stents, or took medication only. The goal was to see which approach best prevents heart attacks and heart-related dea…

This study looked at whether nitrous oxide (laughing gas) is safe for people with heart disease risk factors who need major surgery. Over 7,000 adults aged 45 and older were randomly assigned to receive either nitrous oxide or a gas without it during anesthesia. The researchers t…

This study tested if the exact spot where a needle enters the wrist affects the chance of a painful artery spasm during a heart catheterization. 380 adults were randomly assigned to have the puncture either very close to the wrist bone or a bit farther away. The goal was to find …

This completed study tested whether artificial intelligence could analyze CT scans of the heart to better predict who is at risk for heart attacks or death. Researchers looked at data from 2190 patients with coronary artery disease. The goal was to create a risk score that goes b…

This study looked at whether artificial intelligence (AI) can help predict the risk of heart attacks in people with early signs of heart disease. Researchers analyzed heart scans and health data from 3000 patients. The goal was to find a better way to identify who needs more aggr…

This study looked at how a patient's age, health history, and other factors affect brain oxygen levels during coronary artery bypass surgery. Researchers measured brain oxygen using a special light-based device in 80 adults aged 25-80. The goal was to better understand what influ…

This completed study looked at 160 people with coronary artery disease who needed a stent in one artery and also had a partial blockage in another. Researchers measured pressure in the second blockage before and after stenting the first, to see if treatment changed the reading. T…

This study looked at people with blocked heart arteries that have side branches. Doctors placed a stent in the main artery but did not always open the side branch if blood flow was acceptable. The goal was to see if opening the side branch caused more harm or benefit. About 477 p…

This study looked at how many coronary artery bypass surgeries a surgical resident needs to perform to become skilled at using two imaging tools: transit-time flowmetry and high-frequency ultrasound. These tools help check the quality of the new blood vessels during surgery. The …

This study looked at how well a special heart MRI (called stress CMR) finds blocked arteries in real hospitals, not just research centers. Researchers tracked 2,349 people aged 35-85 who had symptoms of heart disease. They recorded heart attacks, deaths, and hospital visits to se…

This study gathered information from about 2,700 people with coronary artery disease who had a special imaging test called Optical Coherence Tomography (OCT) during a heart procedure. Researchers followed participants for up to 5 years to track major heart problems. The goal was …

This study followed 4000 people who received a XIENCE Xpedition, Alpine, or Sierra stent to open blocked heart arteries. Researchers tracked deaths, heart attacks, and repeat procedures to see how safe and effective these stents are in routine care. The goal was to gather real-wo…

This study looked at whether a non-invasive eye scan (OCTA) can predict how well blood flows in the heart's small arteries. Researchers examined 101 people with coronary artery disease, comparing eye images to measurements taken during heart catheterization. The goal was to see i…

This completed registry study followed 500 Chinese patients who received the Agent DCB, a paclitaxel-coated balloon catheter, during a heart procedure to open blocked arteries. The goal was to collect real-world data on heart-related events like heart attacks or repeat procedures…

This study looked at 2000 adults with early heart disease to understand how inherited high cholesterol (familial dyslipidemia) contributes to heart attacks. Researchers reviewed medical records to find patterns in cholesterol levels. The goal was to highlight the need for better …

This completed study in Egypt examined 1,000 adults with heart disease to see how many reached their LDL cholesterol targets and what got in the way. Participants provided a fasting lipid profile, and researchers looked for patterns and barriers. The goal is to find better ways t…

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This study looked at whether using a thin, 7-French sheath through a small artery in the wrist is safe and effective for opening blocked heart arteries. 100 adults with heart disease took part. The goal was to see if this approach causes fewer bleeding or artery problems while st…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

This study compared radiation exposure to doctors during heart procedures (coronary angiography and stenting) using two different arm artery approaches: the left distal radial artery and the conventional right radial artery. Over 1,000 patients participated. The goal was to see i…

This study looked back at over 2,300 people with known or suspected heart disease who had a stress cardiac MRI. Researchers wanted to see if certain MRI findings could predict future heart attacks or death from heart disease. The goal is to better understand how these scans can h…

This study followed 750 people with severe coronary artery disease who were not eligible for bypass surgery. Researchers tracked survival at 30 days and quality of life at 12 months after less invasive procedures or medical therapy alone. The goal was to understand real-world out…

This study looked at 100 patients with aortic valve sclerosis (a stiffening of the heart valve) and chest pain to see if a blood fat called lipoprotein(a) is linked to the severity of blocked heart arteries. Researchers measured Lp(a) levels from blood samples and compared them t…

This study looked at 135 adults having off-pump coronary artery bypass surgery to see if vitamin D levels affect hemoglobin (a protein in red blood cells) recovery after surgery. Researchers measured vitamin D and a hormone called hepcidin, which controls iron use. The goal was t…

This study looked at 28 people with both stable coronary artery disease and moderate sleep apnea. Researchers measured blood markers of oxidative stress (a type of cell damage) before and after 3 months of CPAP therapy. The goal was to see if CPAP could reduce oxidative stress, w…

This study looked at 116 patients with severe aortic stenosis and moderate coronary artery disease who were scheduled for valve replacement. Researchers measured blood flow in the heart arteries before, right after, and 6 months after valve replacement to see how the procedure af…