CORONARY ARTERY DISEASE

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. Researchers measured blood markers of inflammation in 47 older adults before and after vaccination. The …

This study tested a non-invasive device that gently stimulates a nerve in the ear to see if it can help control blood pressure during heart stent surgery. 480 adults with coronary artery disease and high blood pressure were randomly assigned to receive either the real stimulation…

This study looked at how well the Ultimaster stent works compared to other drug-coated stents in 1,000 adults with coronary artery disease. The goal was to see if it reduces the risk of death, heart attack, or the need for another procedure. Participants received the Ultimaster s…

This study checked if the Orsiro drug-coated heart stent works safely in everyday patients with blocked arteries. Over 550 people who got the stent were followed for a year. The goal was to see how many had serious heart problems like heart attack or needed another procedure. Res…

This study looked at 191 women with non-obstructive coronary artery disease (plaque that doesn't fully block arteries) to see if intensive medical treatment reduces plaque amount and type compared to usual care. Participants had heart CT scans to measure plaque changes and report…

This study tested three doses of a blood thinner called argatroban, given with clopidogrel and aspirin, in 140 people with stable heart disease or unstable angina who needed a procedure to open blocked heart arteries. The goal was to see how well argatroban prevents blood clots a…

This study looked at whether a hepatitis C medication can safely clear the virus in heart transplant patients who received a heart from a donor with hepatitis C. Fifty adults on the heart transplant waiting list took part. Those who got an infected heart received the drug after t…

This study compared two ways of placing stents (small mesh tubes) to open blocked heart arteries at a fork (bifurcation). 425 patients with chest pain took part. The goal was to see which method—crush or culotte—led to fewer heart problems like heart attack or repeat procedures.…

This study tested a simple method using thick gauze and a standard wrist band to prevent the wrist artery from closing up after a heart artery treatment. Over 1500 patients were involved. The goal was to see if this approach reduces blockage and other complications at the punctur…

This study looked at the best way to use drug-eluting stents (small mesh tubes) to open blocked heart arteries that have a side branch. It compared stenting both the main artery and the side branch versus stenting only the main artery and treating the side branch if needed. The t…

This study tested whether a smartphone app and phone calls could help people with heart disease do rehab at home instead of going to a clinic. 258 veterans took part. The goal was to see if this approach improved their ability to exercise, helped them stick with the program, and …

This study tested the Ultimaster stent, a device that helps open blocked heart arteries. The stent slowly releases a drug to prevent re-blockage and then dissolves over a few months. Researchers followed 204 adults with coronary artery disease for one year to see how safe and eff…

This study looked at a special balloon coated with a drug called sirolimus to treat large blockages in heart arteries. 306 adults who already had this balloon treatment were followed for one year to see if they needed another procedure to reopen the same artery. The goal was to c…

This study tested a mobile app-based cardiac rehab program for 259 adults who recently had a heart attack, stent, or heart surgery. The goal was to see if using the app improved walking ability, cholesterol, and overall heart health compared to standard in-person rehab. The progr…

This early study tested a new device called the Supira System in 15 people with coronary artery disease who needed high-risk angioplasty. The device acts as a temporary heart pump to keep blood flowing during the procedure. The goal was to see if it is safe and works as intended,…

This study tested a nurse-led disease management program using a mobile app and telehealth for people with coronary artery disease at high risk of returning to the hospital. 101 participants were split into two groups: one received the program plus usual care, the other usual car…

This study looked at 218 older adults (over 60) with severe calcium buildup in their heart arteries. Researchers compared a drug-coated balloon to a drug-coated stent to see which worked better. The goal was to find a treatment that keeps arteries open without needing a permanent…

This study looked at 220 people with coronary artery disease to see if a blood thinner called ticagrelor could reduce signs of heart muscle injury. Participants had a special PET scan to find high-risk plaques that might rupture without causing symptoms. The goal was to see if ti…

This study tested two different drug-coated stents (everolimus-eluting vs. sirolimus-eluting) in 1,466 people with narrowed heart arteries. It also compared taking the blood thinner clopidogrel for 6 months versus 12 months after stent placement. The goal was to see which stent k…

This study looked at 40 people with diabetes and a high risk of bleeding who received a special heart stent. Researchers used a camera inside the artery to check if it healed enough after one month. If it did, patients stopped one of their two blood thinners early. The goal was t…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart attack, and post-surgery inflammation in people undergoing coronary artery bypass grafting after a recent heart attack or unstable angina. One hundred adults w…

This study looked at 112 adults who had a severe heart attack and multiple blocked arteries. It compared fixing all blockages in a single procedure versus doing them in separate sessions over a month. The goal was to see if the one-time approach reduces hospital stays, costs, and…

This study looked at whether taking aspirin twice a day (100 mg each time) works better than the usual once-a-day dose to prevent another heart attack, stroke, or urgent heart procedure in people with diabetes who have had a recent heart attack or unstable angina. About 2,500 par…

This study tested a very small balloon catheter (0.85-1.25 mm) in 170 people with completely blocked heart arteries (chronic total occlusion). The balloon was used to open the blockage before placing a stent. Researchers checked if the balloon could be safely delivered, inflated,…

This study tested a new type of stent made from magnesium that slowly dissolves over time. The stent releases a drug to prevent artery re-narrowing and was used in 20 patients with heart disease and complex blockages. The goal was to see if the stent is safe and works well in the…

This study tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had heart disease risk factors like obesity and high cholesterol. The goal was to see if the drug could safely improve skin symptoms and reduce inflammation. Participants received ei…

This study tested a new type of heart stent that slowly dissolves after opening blocked arteries. It involved 1629 people with stable heart disease or mild heart attacks. The goal was to see if this stent works as well as standard stents in keeping arteries open and preventing fu…

This study tested whether quercetin, a natural compound found in fruits and vegetables, can reduce inflammation and signs of cell aging in 100 people undergoing coronary artery bypass surgery. Participants received quercetin or a placebo before and after surgery. The goal was to …

This study looked at two types of stents (small mesh tubes) used to open blocked heart arteries. Over 3,000 people received either a newer everolimus-coated stent or an older sirolimus-coated stent. Researchers tracked heart attacks, deaths, and the need for repeat procedures to …

This study tested whether an Ayurvedic herbal supplement called Maharishi Amrit Kalash (MAK) could improve blood vessel function better than vitamins C+E or a placebo. It included 143 African American adults aged 55+ with heart disease or high risk. Researchers measured artery di…

This study looked at a device called Coroflex ISAR Neo, a stent used to open blocked heart arteries. Over 3,500 adults with coronary artery disease took part. The main goal was to see how often the treated artery needed to be reopened within a year. The study also tracked serious…

This study tested whether a single daily pill containing a statin, aspirin, and a blood thinner could help underserved heart attack patients who received a stent stick to their medications. 140 adults took either the polypill or their usual separate medicines. The goal was to see…

This study tested a newer type of heart stent (Xience Sierra) in 1757 people with heart disease, including many with diabetes or prediabetes. The goal was to see if the stent is safe and works well in both general and high-risk patients. Researchers tracked heart-related events l…

This study tested a stent retriever, a device used in strokes, to remove blood clots during heart attacks. 81 patients with severe heart attacks were treated either with the new device or standard care. The goal was to see if the stent retriever could reduce damage to small heart…

This study looked at whether taking two blood thinners (clopidogrel and aspirin) for a longer time after getting a heart stent helps prevent future heart attacks, strokes, or death in people with multiple blocked heart arteries. About 8,250 adults aged 18-75 who already had a ste…

This study tested a new device that uses sound waves to break up calcium buildup in heart arteries before placing a stent. 145 people with hardened arteries took part. The goal was to see if the device is safe and helps stents work better.

This study tested whether a special balloon that uses sound waves (lithoplasty) is better than standard balloons for preparing severely calcified (hardened) coronary arteries before placing a stent. 200 adults with stable heart disease or non-emergency heart attacks took part. Th…

This study tested whether a daily breathing exercise called inspiratory muscle strength training (IMST) can improve blood flow to the heart in people with coronary artery disease. Forty adults completed either a high-intensity or low-intensity version of the exercise for 8 weeks.…

This study looked at how safe and effective a new type of drug-coated stent (Genoss) is for people with serious coronary artery disease. Researchers followed 200 patients for a year to track heart-related deaths, heart attacks, and the need for repeat procedures. The goal was to …

This study looked at using a special balloon coated with medicine to reopen completely blocked heart arteries. 309 patients were treated and followed for 6 months to see if the artery stayed open and if there were any heart problems. The goal was to find a better way to treat the…

This study looked at whether using a person's genetic information to choose their blood thinner (clopidogrel or an alternative) leads to better outcomes after a heart procedure. About 283 adults with chronic coronary artery disease who had a stent placed were split into two group…

This study looked at whether a new type of CT scanner (photon-counting detector CT) can provide clearer images of coronary artery disease compared to standard scans. 243 adults with suspected heart disease were scanned both with and without a drug that stresses the heart. The goa…

This study tested whether artificial intelligence (AI) can predict coronary artery disease using information collected without touching the patient, like facial images or voice. Nearly 3000 people suspected of having heart disease took part. The goal was to see if this non-contac…

This early-phase study tested a new radioactive tracer called 68Ga-Galmydar for PET scans of the heart. Fifteen adults with known or suspected coronary artery disease received the tracer to see how well it shows blood flow to the heart muscle. The goal is to improve detection of …

This study tested an AI tool to help decide which low-risk patients with suspected heart disease should get a safer CT scan instead of an invasive heart catheterization. The goal was to reduce unnecessary invasive procedures, which are costly and carry risks. About 251 adults ref…

This study tested a new, non-invasive imaging technique to measure blood flow in the heart muscle. It involved 36 people with coronary artery disease who already needed a heart catheterization. The goal was to see if the new method could give the same results as the standard inva…

This study tested whether a computer algorithm can detect coronary artery disease by analyzing facial photos. Researchers enrolled 100 community adults with a moderate risk of heart disease. The goal was to see how sensitive and specific the facial photo screening method is compa…

This study looked at whether using different blood test thresholds for men and women can help doctors more accurately diagnose heart attacks. Current tests use the same cutoff for everyone, but healthy women naturally have lower troponin levels than men, which may lead to missed …

This study looked at 1,400 people with stable chest pain to see if a special CT scan (FFRct) is better than the usual tests recommended by NICE for diagnosing heart disease. The main goal was to see which approach uses fewer healthcare resources. The study is complete and may hel…

This study tested two different contrast agents (Dotarem and Gadovist) used during heart MRI scans to see if they produce equally clear images. 120 adults with coronary artery disease or cardiomyopathy were randomly assigned to receive one of the two agents. The goal was to compa…

This study compared two types of heart scans—CT and PET—to see how well they measure blood flow in people with coronary artery disease. Twenty adults who already needed a CT scan for their heart took part. The goal was to find out if the newer CT method works as well as the stand…

This study tested whether using a special CT scan analysis (FFRCT) to guide decisions is better than usual care for people with suspected heart artery disease. About 584 adults with intermediate risk were followed for 90 days. The goal was to see if FFRCT could reduce the number …

This study tested whether a detailed ultrasound (IVUS) of the heart's arteries can accurately diagnose reduced blood flow (functional ischemia) in 105 people with coronary artery disease. Researchers compared IVUS plaque measurements to the standard pressure-wire test (FFR). The …

This study tested whether giving sodium bicarbonate (a type of baking soda) or N-acetylcysteine (a common supplement) before angiography could prevent serious kidney damage in over 5,000 high-risk patients. Participants had existing kidney disease or diabetes and were getting a p…

This study tested whether giving the painkiller acetaminophen (Tylenol) through an IV every 6 hours during and after heart surgery could prevent delirium—a state of sudden confusion—in patients aged 60 and older. Delirium is a common and serious complication after heart surgery. …

This study looked at whether special nerve blocks (PECS II, parasternal, and serratus plane blocks) can reduce pain after minimally invasive heart bypass surgery (MIDCAB). Researchers reviewed records of 88 adults who had this surgery, comparing those who got the blocks to those …

This study tested whether using virtual reality (VR) during femoral sheath removal after coronary angiography can lower pain, anxiety, and changes in vital signs. One hundred adults were randomly assigned to either wear VR goggles or receive standard care during the procedure. Th…

This study looked at whether amlodipine, a blood pressure medicine, can help people with stented heart arteries exercise longer and use less chest pain medication. About 211 stable angina patients with narrowed arteries took part. The goal was to see if amlodipine improves oxygen…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) could better control pain after heart surgery. 62 adults having planned heart surgery through a breastbone incision were enrolled. The…

This study tested whether using nerve blocks with sedation instead of general anesthesia and opioids is safer and provides better pain control for high-risk patients needing an upper leg amputation. The study included 30 adults with conditions like diabetes, heart disease, or lun…

This study looked at whether playing music during an angiography (a procedure to check heart arteries) can help patients feel less anxious and keep their vital signs stable. Fifty adults with coronary artery disease took part; half listened to music during the procedure, and half…

This study tested whether starting a gentle exercise program within 24 hours after coronary artery bypass surgery helps patients recover faster. Forty adults who had their first bypass surgery took part. The exercise group did supervised sessions twice a day for 5 days, including…

This study tested whether a 12-week home-based telerehabilitation program works as well as traditional center-based rehab for people who had coronary artery bypass surgery. 110 stable patients aged 30-75 were randomly assigned to home rehab, center rehab, or usual care. The main …

This study tested a special 'ultra-fast-track' anesthesia for people having heart bypass surgery. The goal was to wake patients up and remove their breathing tube right in the operating room or within an hour, instead of the usual ICU stay. Researchers compared 100 patients to se…

This study looked at 135 adults having heart bypass surgery to see if vitamin D levels affect how well their blood (hemoglobin) recovers after the operation. Researchers measured vitamin D and a protein called hepcidin, which controls iron in the body. The goal was to understand …

This study tested a new device called the Vis-Rx Prime Micro-Imaging Catheter, which takes detailed pictures inside the heart's arteries during a standard heart procedure. 34 adults with coronary artery disease participated. The goal was to see how well the catheter worked and ho…

This study tested whether an Apple Watch can reliably measure key health indicators like oxygen use during exercise in people with heart conditions. Researchers compared smartwatch data to standard medical equipment in 50 adults with heart disease or in athletes. The goal was to …

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked if it could predict death or heart problems. They also tested if a diabetes d…

This study looked at over 17,000 people with coronary artery disease who received drug-eluting stents (tiny mesh tubes coated with medicine) to open blocked heart arteries. Researchers compared different types of stents to see how well they worked and how safe they were over the …

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). Over 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart att…

This study looked at 3000 patients with suspected coronary artery disease to see if artificial intelligence could better predict who is at risk for heart attacks or death. Researchers used heart scan images and patient health data to build a risk model. The goal is to help doctor…

This study looked at 2190 people with coronary artery disease who had a CT scan. Researchers used artificial intelligence to find hidden signs of risk that doctors might miss. The goal was to create a score that helps predict who might have a heart attack or need urgent care, so …

This study looked at 116 people with severe aortic stenosis (a narrowed heart valve) and moderate coronary artery blockages. Researchers measured blood flow in the heart arteries before, right after, and 6 months after valve replacement surgery. The goal was to understand how the…

This study looked at 60 postmenopausal women with stable coronary artery disease to see how the flavonoid quercetin (found in fruits and vegetables) and the statin atorvastatin affect estrogen levels and a protein called SIRT1. The goal was to understand possible links between di…

This study followed 750 people with severe coronary artery disease who were not eligible for bypass surgery. Researchers tracked how well they did after a less invasive procedure called percutaneous revascularization (stenting). The goal was to see survival rates at 30 days and q…

This study looked at how two different exercise programs affect heart function and blood pressure in men over 45 with high blood pressure and coronary artery disease. Forty participants did either interval training or continuous training, including both aerobic and resistance exe…

This study looked at people with heart disease who had a blocked main artery with a side branch that also had some blockage but still had acceptable blood flow. Doctors wanted to know if it was better to also open that side branch with a balloon after placing the main stent, or t…

This study looked at whether a heart artery procedure (angioplasty) can be done safely through a small tube placed in the wrist near the hand. 100 adults with heart disease took part. The main goal was to check for complications like bleeding or artery blockage. The approach appe…

This study looked at 4,000 people with coronary artery disease who received a XIENCE stent during a routine procedure. Researchers tracked deaths, heart attacks, and the need for repeat procedures to see how safe and effective the stent is in everyday use. The goal was to gather …

This study looked at 160 people with heart disease who needed a procedure to open a blocked artery. Researchers wanted to see if treating that blockage changed pressure measurements in a different, partially blocked artery. They measured pressure before and after the procedure to…

This study collected information from 66 adults who had a heart CT scan to measure the amount of radiation used in everyday medical practice. The goal was to see how radiation doses vary between different hospitals and CT machines, and how often dose-saving techniques are used. T…

This study looked at whether using very small breaths (ultra-low tidal volume) during heart bypass surgery can reduce strain on the lungs and help patients recover faster. Sixty adults having planned bypass surgery were randomly assigned to receive either these small breaths or n…

This study gathered information from about 2,700 people who had a special imaging test called Optical Coherence Tomography (OCT) during a heart catheterization. The goal was to track major heart problems like heart attacks over up to 5 years. Researchers hope this data will help …

This study followed 318 people with suspected coronary artery disease for about 10 years to see whether starting with a CT scan or an invasive angiogram is better for long-term heart health. Participants had atypical chest pain and were originally part of an earlier trial. Resear…

This study looked at past medical records and images from 100 people with heart artery disease. Researchers developed and tested a computer algorithm that uses ultrasound images from inside the artery to estimate blood flow blockage, comparing it to the standard wire-based measur…

This study looked at 380 adults having a heart catheterization through the wrist. It compared two puncture spots to see if one causes less artery spasm, a common painful complication. The goal is to find the best spot to make the procedure more comfortable.

This study looked at 28 people with both stable coronary artery disease and moderate sleep apnea. Researchers measured markers of oxidative stress (a type of cell damage) in the blood before and after 3 months of CPAP therapy. The goal was to see if CPAP reduces oxidative stress,…

This study looked at 60 heart surgery patients to see how blood flow in tiny blood vessels (microcirculation) differs between two types of heart-lung machines: a newer, less invasive one and a standard one. The goal was simply to observe and compare, not to treat a disease. Resul…

This study looked at 2000 adults hospitalized for a heart attack or unstable angina to understand how inherited high cholesterol (familial dyslipidemia) relates to early heart disease. Researchers reviewed medical records to identify patterns of abnormal blood fats and how often …

This study tested whether a simple, non-invasive eye scan could predict how well blood flows through the heart's tiny arteries. Researchers measured blood flow in the heart and eyes of 101 people with coronary artery disease. They used machine learning to see if eye measurements …

This study looked at how well a specific heart stent (PROMUS PREMIER) works in everyday medical practice in China. Over 2,000 patients with coronary artery disease were followed for 12 months to track serious heart events like heart attacks or the need for repeat procedures. The …

This completed study from Cairo University involved 1,000 adults with heart disease to see how many reached their LDL cholesterol targets and what got in the way. Researchers surveyed patients to find barriers like side effects or confusion about medications. The goal is to help …

This study looked at whether using a heart ultrasound (TEE) during low-risk bypass surgery should be done routinely or only when needed. Researchers enrolled 40 adults with good heart function to compare the two approaches. The goal was to gather information to help doctors decid…

This study looked back at data from over 2,300 people who had a stress cardiac MRI to see if certain heart function and structure findings could predict serious heart problems like heart attack or death. The goal was to understand how these MRI results relate to long-term outcome…

This study looked at 43 people with stable coronary artery disease who needed a balloon procedure to open blocked heart arteries. Researchers measured blood flow right after the procedure to see how different balloon types (scoring vs. regular) affected results. The goal was to b…

This study looked at whether small differences in genes related to the apelin system (which helps control blood pressure) are linked to a higher risk of coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 Syrian patients, comparing those w…

This study followed 514 people with stable coronary artery disease for 18 months to see if how their bodies handle triglycerides (a type of fat) after a meal could predict future heart problems. Researchers also looked at blood sugar control and other health markers. The goal was…

This study tested a new way for patients to share their family health history with their doctor using an app. The goal was to see if this helps doctors spot people at higher risk for certain cancers, heart disease, or diabetes. Over 600 adults aged 30-69 took part. The approach i…

This study looked at whether using nitrous oxide (laughing gas) during major surgery is safe for people at risk of heart problems. Over 7,000 adults aged 45 and older were randomly assigned to receive either nitrous oxide or a similar gas without nitrous oxide. The researchers tr…

This small pilot study looked at whether drinking beet juice could improve blood vessel and breathing muscle function in older adults with coronary artery disease. Eight participants were given either nitrate-rich beet juice or a placebo to see if the study design was feasible an…

This study looked back at 65 heart disease patients who completed a cardiac rehabilitation program. Researchers checked if their ability to exercise, mood, quality of life, and sleep improved after the program. The goal was to see how helpful rehab is for people with heart condit…

This study tested an AI system that uses optical character recognition and large language models to automatically pull key information from medical records of 308 patients with coronary artery disease. The AI extracted 10 clinical details (like lab results) and diagnosed disease …

This study checked if a blood fat called lipoprotein(a) can predict how blocked the heart arteries are in people with a stiff heart valve (aortic valve sclerosis). Researchers studied 100 adults with chest pain or shortness of breath. They found that higher lipoprotein(a) levels …

This study looked at 1,695 people with stable heart disease affecting multiple arteries. Researchers compared long-term outcomes of bypass surgery, stenting, or medication alone to see which best prevents heart attacks and heart-related death. The goal is to help doctors and pati…

This study looked at how many coronary bypass surgeries cardiac surgery residents need to perform to become skilled at using two imaging tools that check the quality of new blood vessel connections during surgery. 80 adult patients having bypass surgery took part. The goal is to …