New CT scanner aims to replace invasive heart tests for High-Risk patients

NCT ID NCT04272060

Completed Diagnosis Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. The goal is to see if the UHR-CT can accurately identify which patients need further treatment without the risks of an invasive procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ultra-high-resolution CT scanner
What this could lead to: If successful, this could offer a noninvasive alternative to cardiac catheterization for diagnosing coronary artery disease in patients with severe calcification or stents.
What could go wrong: This is a small, early-phase study with only 50 patients, so results may not apply broadly. The CT may still miss some blockages compared to the invasive gold standard.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

Hospital Israelita Albert Einstein

São Paulo, Brazil
Iwate Medical University

Morioka, Japan
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States

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