Could donor blood particles protect hearts after stenting?
NCT ID NCT04327635
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tested whether a biologic called PEP, made from donor blood particles, is safe to infuse into heart arteries right after stent placement. Nine patients received a single dose during catheterization. The goal was to see if PEP could reduce heart damage, but the main focus was on safety and finding the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PEP (extracellular vesicles from donor blood)
What this could lead to
If safe, this could lead to a new way to limit heart muscle damage after stent placement.
What could go wrong
This is a very early Phase 1 trial with only 9 participants, so safety and effectiveness are not yet proven. There are risks of allergic reactions, infection, or heart rhythm problems.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States