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Heart surgery patients get faster healing with own blood plasma

NCT ID NCT07352020

Disease control Sponsor: Shaheed Zulfiqar Ali Bhutto Medical University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether applying a patient's own platelet-rich plasma (PRP) to the chest wound during heart surgery reduces infections and improves healing. 98 adults undergoing bypass surgery were randomly assigned to receive PRP or standard wound closure. Results showed that PRP may lower wound complications and hospital costs, but lifelong medication is not involved, so this is classified as disease control.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

98 people

The number who actually took part.

Started

Jul 2022

Finished

Feb 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 72 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 45 to 72 years, undergoing median sternotomy for CABG surgery. Able and willing to provide informed consent. Exclusion Criteria: * Known Diabetics, Patients unable or ineligible to donate blood for standard blood bank procedures, which includes those with low hemoglobin, blood disorders, infections, or other medical conditions preventing safe blood collection Patients from whom autologous platelet-rich plasma (PRP) cannot be obtained due to low platelet counts, blood disorders, or other technical/medical reasons Cardiopulmonary bypass (CPB) time \> 72.5 minutes Bilateral internal mammary artery harvested Body Mass Index (BMI) \< 18.5 or \> 24.9 Active smokers Chronic lung disease Osteoporosis Current steroid therapy

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Conditions

The condition(s) this trial relates to.

coronary artery disorder mediastinitis Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep sternal wound infection Delayed sternal wound healing Delayed wound healing Mediastinitis Superficial sternal wound infection Surgical site infection (SSI)

Contacts and locations

Locations

  • Pakistan Institute of Medical Sciences

    Islamabad, Islamabad/Punjab, 44000, Pakistan

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