Heart bypass drug showdown: which pill keeps arteries open longest?

NCT ID NCT04310995

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take one of the three drugs for 24 weeks, with follow-up imaging and check-ups at 1 week, 24 weeks, and again after 5 years. The goal is to find the most effective anti-spasm treatment to keep grafts open and reduce future heart problems.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    Shanghai, 200025, China

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