Can a natural supplement boost heart drug benefits in older women?

NCT ID NCT05877235

Completed Disease control Sponsor: InCor Heart Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 60 postmenopausal women with stable coronary artery disease. Researchers tested whether adding a daily 1000 mg quercetin supplement to standard atorvastatin treatment could affect levels of estrogen and a protein called SIRT1, which are linked to heart health. The goal was to see if this combination might offer extra benefits beyond statins alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: quercetin (a natural antioxidant found in fruits and vegetables) and atorvastatin (a statin drug)
What this could lead to: If it works, this could point toward a way to improve heart health in postmenopausal women by combining a common statin with a natural supplement.
What could go wrong: This is a small, early-stage study (60 participants) that only measured blood markers, not actual heart events. The results may not lead to a new treatment or apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis coronary artery disorder Coronary Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE MENOPAUSE

Contacts and locations

Locations

INCOR- Heart Institute

São Paulo, São Paulo, 05403900, Brazil

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